I once asked my mom for her secret recipe for barbeque steak. I would savor each bite as it filled my mouth with delicious flavor. I started salivating when I read her well-worn 3×5 card with the list of ingredients: steak, garlic (lots!), sugar, soy sauce, spring onions, rice wine, pepper, sesame seeds, and sesame oil. I felt like I discovered her hidden secret for flavor when I read: “poke holes in the meat with a fork and marinade overnight in the refrigerator.”

How can knowing about marinades help you to fight a persistent mycoplasma infection?

Mycoplasma infections can be found throughout into the body
Mycoplasmas are very small bacteria that can spread throughout the body and have been found especially in the lungs and heart¹, central nervous system², and the blood³. Mycoplasma infections have been linked to illnesses including: multiple sclerosis⁴, cancer⁵, chronic fatigue syndrome and fibromyalgia⁶, arthritis and hepatitus⁷. Patients report a wide range of symptoms including: respiratory tract infections, fever, chest pain, neurological problems, meningitis, encephalitis, and hemolytic anemia. These symptoms may persist despite antibiotic treatment because mycoplasma can develop drug resistance.

Antibiotic resistant mycoplasma infections are being found across the world
In multiple studies, macrolide or tetracycline antibiotic resistant mycoplasma have been found in North America⁸, Asia^9,10, and Europe¹¹. These germs can also form biofilms¹², which can increase drug resistance up to five-thousand fold¹³. In addition to developing drug resistance, these germs can also hide inside cells¹⁴ which makes killing them much more challenging.

What else besides antibiotics can help you fight a persistent biofilm and intracellular mycoplasma infection?

Essential oils may help you fight a persistent mycoplasma infection
Fortunately, there are five essential oils that have anti-mycoplasma properties. These oils have been effective against multiple mycoplasma species. When these oils are formulated into a microparticle called a liposome, they may have a greater ability to penetrate deeper into biofilms and inside cells and kill mycoplasma in their hiding places. Fortunately, these essential oils have been used safely for decades for food preservation and in therapeutic treatments topically and internally.

Anti-Mycoplasma Essential Oil #1: Bergamot orange, Citrus Bergamia
The properties of this essential oil are cooling, refreshing, and astringent. It is recognized by the US Food and Drug Administration (FDA) as Generally Recognized as Safe (GRAS)¹⁵. However, bergamot essential oils that contain furanocoumarins are phototoxic potentially carcinogenic, and can lead to blistering if exposed to UV light or sunlight after being applied to the skin topically. Fortunately, there are furanocoumarin-free oils, labelled as bergamot essential oil (FCF) which are non-toxic¹⁶.

In one experiment, bergamot essential oil and its major components (limonene, linalyl acetate and linalool were tested against forty-two strains of Mycoplasma hominis, two strains of Mycoplasma fermentans, and one strain of Mycoplasma pneumoniae. All strains were inhibited at 0.5% (M. hominis and M. pneumonia) to 1% (M. fermentans) minimum inhibitory concentration (MIC) levels by bergamot essential oil. Linalyl acetate was highly effective against M. hominis and M. pneumonia with MIC levels of 0.015% and M. fermentan at MIC levels of 0.12%. Linalool had MIC values of 0.015% against M. pneumoniae, 0.06% MIC levels against M. fermentans, and 1% MIC levels against M. hominis. Limonene had MIC levels of 0.03% against M. pneumoniae, 1% against M. fermentans, and >4% against M. hominis¹⁷.

In other experiments, liposomal bergamot essential oil demonstrated anti-cancer properties¹⁸, the essential oil modulates intracellular calcium levels¹⁹, vaporized bergamot and orange essential oils remove methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus sp. (VRE) and their biofilms²⁰, lavender and bergamot essential oil mixture helps to reduce anxiety and depression²¹, and bergamot essential oil has anti-inflammatory and anti-oxidant effects²². Another essential oil derived from tea tree also has anti-mycoplasma properties.

Anti-Mycoplasma Essential Oil #2: Tea tree, Melaleuca alternifolia
The properties of this essential oil are warming and fragrant. High doses, approximately a teaspoon to a half a teacup, of tea tree oil have resulted in ataxia, drowsiness, diarrhea, unconsciousness, and allergic reactions. Maximum topical dose is 15% when combined with other essential oils or carrier oils²³.

In two studies, tea tree essential oil demonstrated anti-mycoplasma effects at very low concentrations. Against M. pneumoniae, MIC was 0.006% for the wild type and 0.003% against mutant strains²⁴. In the second study, M. pneumoniae showed MIC values of 0.01%, M. fermentans, showed MIC values of 0.06%, and M. hominis was 0.12%²⁵.

In other studies, tea tree has been effective against drug resistant MRSA, streptococcus, and candida²⁶, reducing inflammation and stimulating pro-inflammatory cytokines²⁷, and preventing influenza²⁸. A combination of essential oils also demonstrated anti-mycoplasma properties in an animal study.

Anti-Mycoplasma Essential Oils #3: Peppermint, Mentha piperita combined with #4 Eucalyptus, species
The properties of peppermint essential oil are cooling, releases the exterior, and pungent. It is recognized by the US Food and Drug Administration (FDA) as Generally Recognized as Safe (GRAS)²⁹. However, massive doses of peppermint essential oils, 4g/kg, produce neurotoxicity, hepatotoxicity, convulsions, and paralysis in animal studies³⁰.

In one animal study, a commercial combination of peppermint and eucalyptus essential oils (Mentofin) helped to reduce the effects of a Mycoplasma gallisepticum and H9N2 infection in chickens by reducing mucus production and levels of intracellular infection³¹. In laboratory studies, peppermint essential oil combined with beta-lactam antibiotics reduces antibiotic resistance in drug resistant E. coli³², demonstrated moderate antibacterial activity against: Listeria monocytogenes, Clostridium perfringens, Bacillus cereus, Staphylococcus aureus, Enterococcus faecium, Enterococcus faecalis, and Staphylococcus epidermidis, Salmonella enterica, and Pseudomonas aeruginosa³³, inhibits candida and it’s biofilms³⁴., and peppermint combined with spearmint essential oil reduces chemotherapy-induced nausea and vomiting³⁵. Peppermint essential oil use is contraindicated in cases of cardiac fibrillation and in patients with a G6PD (Glucose-6-Phosphate Dehydrogenase) deficiency.

Anti-Mycoplasma Essential oil #4 Eucalyptus, spp
The properties of eucalyptus essential oil are cooling, disperses wind, and releases the exterior. This essential oil is contraindicated in patients with inflammatory disease in their gastro-intestinal tract and bile ducts, and in cases with severe liver disease³⁶. Multiple cases of acute toxicity have been reported in adults and children after ingesting 5 ml to 75 ml with signs of central nervous system depression, abnormal respiration, and pinpoint pupils. Other symptoms of acute toxicity may include: stomach pain, vomiting, weak legs, cold sweats, headaches, and even death.

In laboratory and animal tests, eucalyptus essential oil demonstrated anti-bacterial activity against E. coli³⁷, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), multi-resistant Pseudomonas aeruginosa, ESBL-producing Escherichia coli and Klebsiella pneumoniae³⁸, Streptococcus mutans³⁹, Candida albicans⁴⁰, and reduces inflammation⁴¹. In addition to peppermint and eucalyptus, cinnamon oil was also effective at inhibiting mycoplasma.

Anti-Mycoplasma Essential Oil #5 Cinnamon bark
The properties of cinnamon essential oil are hot and sweet. It is recognized by the US Food and Drug Administration (FDA) as Generally Recognized as Safe (GRAS)⁴². In a lab study, cinnamon bark essential oil had antimicrobial activity against fifty clinical isolates of Mycoplasma hominis⁴³. In multiple lab studies, cinnamon bark essential oil has also been effective against drug persistent Lyme disease and it’s biofilms⁴⁴, drug-resistant Candida⁴⁵, Brucella abortus⁴⁶, and Aspergillus mold species and it’s toxins⁴⁷. In another lab study, liposomal cinnamon bark essential oil was effective at inhibiting drug resistant staphylococcus (MRSA) and it’s biofilms⁴⁸.

Caution: cinnamon oil has produced allergic dermatitis in some cases when placed on the skin. This oil may interfere with blood clotting. In one case, a boy drank 60 ml of cinnamon oil upon a dare and experienced symptoms of burning sensation in the mouth, chest and stomach, dizziness, double vision, nausea, vomiting and later collapsed. Microparticle essential oils may help enhance the fight against persistent mycoplasma symptoms.

Patients with mycoplasma report a significant reduction of chronic symptoms
After taking internal doses of microparticle “liposomal” essential oil mixtures containing one or more of the oils above, several patients have reported significant reduction in muscular and joint pain, headaches, insomnia, inflammation, fatigue, and mental fog, and confusion. In some cases, symptoms were aggravated due to a toxic die off Herxheimer reaction. Using essential oils in a careful, targeted strategy may help to reduce persistent mycoplasma symptoms.

The right essential oils can help you to fight off a persistent mycoplasma infection
Just like the right marinade, the proper anti-mycoplasma essential oils in a microparticle liposome may penetrate deeper into cells, under biofilms, and into the brain where mycoplasmas can cause troubling symptoms. These oils may help to significantly reduce the persistent pain, fatigue, and mental fog caused by these germs. Since these oils come with cautions and contraindications on their use, work with a Lyme literate essential oil practitioner to develop a safe and effective essential oil strategy for your condition.

– Greg

P.S. Do you have experiences where treatment or remedies helped you eliminate or reduce inflammation and fatigue from a mycoplasma infection? Tell us about it.

>> Next step: Come to our live evening lecture: Getting Rid of Lyme Disease in Frederick, Maryland on Monday January 8th at 6pm to learn more about treatments and remedies for stopping treatment resistant mycoplasma, Lyme disease, drug resistant infections, neurological problems, inflammation, and pain: https://goodbyelyme.com/events/get_rid_lyme

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