Two Frogs is moving into a larger office suite on Monday August 17th!

On Monday August 17th, we will open at our new location inside the:

Healing Circles Wellness Center at
10 North Jefferson Street
Suite 203
Frederick, MD 21701

There are multiple visitor spaces (highlighted in blue) across from the front entrance of the West Park office building. If all the visitor spaces are taken, you can park on Jefferson Street.

Here is what the ground floor lobby looks like:

Go up the elevator to the 2nd floor. Turn left out of the elevator and go through the door with the Healing Circles Wellness Center logo:

Have a seat in the waiting area. There is water and a restroom key in the waiting area for the restrooms by the elevator.

We will be closed on Friday August 14th and will re-open on Monday August 17th.

Question? Call us at 301-228-3764 or email at TwoFrogsHealingCenter@gmail.com.
We look forward to seeing you in our new space on or after Monday August 17th!

Thanks,

Greg

For people with recurring fatigue, shortness of breath, and a pale complexion that are diagnosed with Babesia, Bartonella, or Mycoplasma by Greg Lee

A few years ago, I decided to grow sweet potatoes in my garden. Tiny sprouts grew into long vines with lavender flowers and triangle shaped leaves. At harvest time, one of the potatoes was much thinner than the others. When I picked it up, the center had been hollowed out by some unknown pest.

How is a hollowed out sweet potato like a person with a low red blood cell count caused by a tick co-infection?

Similar to a hollow potato, a person can have their red blood cells eaten out by tick co-infections
Ivan wondered each morning if he would be able to make it out of bed. Some mornings, Ivan felt debilitating fatigue and could barely make it to the bathroom. Other days he felt good enough to get up and go to work. He hoped he had enough energy to make it through the day. His Lyme literate doctor diagnosed him with anemia due to a Babesia infection and placed him on anti-malarial medications to stop the infection. He felt better for a while.

A Babesia infection can destroy red blood cells which can lead to anemia
People diagnosed with Babesia, Bartonella, and/or Mycoplasma can have their red blood cells (RBCs) destroyed by their infections. Babesia and Bartonella slip inside of and eat out the insides of RBCs. Mycoplasma pneumonia can stimulate the immune system to produce antibodies that destroy RBCs. As more and more RBCs get destroyed, a condition called hemolytic anemia can occur which is defined as the abnormal destruction of these cells faster than bone marrow can produce them. Symptoms of anemia can also affect the brain.

Anemia can also mess up your problem solving ability, thinking speed, and memory recall
In one study, anemic women scored worse on planning, speed, spatial working memory and strategy tests than those with normal iron levels. When their iron levels increased after eating iron rich foods, their scores increased significantly¹. In another study on a similar protozoa infection to Babesia, Severe Malarial Anemia (SMA) is associated with long-term impairment in cognitive ability, whereas Cerebral Malaria (CM) is associated with additional impairment in the areas of attention and associative memory. SMA is hypothesized to be a major contributor to long-term neuro-cognitive impairment in children². Anemia can also produce symptoms of extreme fatigue, pale complexion, and shortness of breath. Infectious anemia can persist despite being treated with antimicrobial drugs.

Unfortunately, drug resistant strains of Babesia, Bartonella, and Mycoplasma can cause relapsing anemia
Ivan found that his symptoms of fatigue, brain fog, and memory recall problems slowly returned a few months after taking different anti-malarial drugs. His electrodermal scan indicated the signature frequencies of Babesia, Bartonella and Mycoplasma pneumonia. Unfortunately, Babesia microti has been able to develop antimicrobial resistance to azithromycin-atovaquone³. Strains of Bartonella have demonstrated antibiotic resistance to azithromycin, pradofloxacin and enrofloxacin⁴; gentamicin⁵; rifampin⁶; quinolones⁷; and fluoroquinolones⁸. Strains of Mycoplasma pneumonia has been able develop resistance to macrolides (Azithromycin, Clarithromycin, Erythromycin, Fidaxomicin, and Telithromycin)⁹.

What else besides medications can help reverse symptoms relapsing anemia symptoms in people with multiple co-infections?

Here are five herbs for relieving recurring symptoms of anemia from co-infections
In Chinese herbal medicine, there are groups of herbs that are classified as “Blood Building or Tonifying” and “Blood Invigorating” herbs. Many of these have been used safely for thousands of years to treat patients with anemia. Within these groups, there are five main herbs that have helped patients like Ivan to reduce or eliminate recurring fatigue, brain fog, and memory problems related to an underlying anemia. Ivan received a liposomal mixture of these herbs, which contains microscopic particles of his herb formula that were wrapped in a fat called lecithin. Liposomal mixtures penetrate more deeply into cells than their non-liposomal equivalent medications. Liposomal drugs were 40 times more effective at delivering medicine into and clearing out a malaria infection from red blood cells in a mouse study¹⁰.

Build Blood Herb #1: Angelica sinensis, Chinese name: Dang Gui
This herb derives its name from a tragic love story. A newly married man is taunted by other men in his village. He goes off to prove his manhood by seeking his fortune. He tells his wife that she is free to remarry if he does not return in three years. Three years passes and she remarries. He returns and both of them are heartbroken. She becomes bedridden as a result of her heartbreak. He gives her a root which brings her health back. Dang translates to “should” and Gui can be translated to “come back¹¹.”

“Dang Gui is characterized as sweet, warm, and acrid. It has been used for treating anemia for thousands of years. This herb is also used for symptoms of pale complexion, brittle nails, dizziness, blurred vision, and palpitations. It has also been used to treat postpartum fatigue, weakness, insomnia, excessive dreaming and worrying, forgetfulness, hot flashes, irritability, abdominal pain, menstrual disorders, blood stagnation which is similar to hypercoagulation, insufficient lactation, traumatic injuries, numbness and pain in the extremities, coldness, sores, abscesses, ulcers, swelling, burning, constipation, cough, and dryness.

This herb is cautioned in patients with abdominal distention, loose stools, or diarrhea. It is contraindicated in patients with excess heat. It is suggested that Dang Gui may potentiate the effects of anticoagulant or anti-platelet drugs. In multiple studies, Dang Gui increases overall blood circulation by decreasing blood viscosity, reduces plasma cholesterol and triglyceride levels, and decreases the risk of atherosclerosis. It has also increased macrophage activity, protects the liver. This herb has shown an inhibitory effect on Salmonella typhi, E. Coli, Corynebacterium diptheriae, Vibrio cholerae, alpha-hemolytic streptococcus, and beta-hemolytic streptococcus.

It has been used to treat the following conditions: low back and leg pain, arrhythmia, coughing, stroke, migraine, nephritis, pain, upper gastrointestinal bleeding, liver disease, menstrual pain, uterine prolapse, insomnia, herpes zoster, alopecia, psoriasis, and deafness¹².”

Build Blood Herb #2: Cooked Rehmannia Root, Chinese name: Shu Di Huang
“Cooked rehmannia is characterized as sweet and slightly warm. This herb has been used for blood deficiency, pale complexion, dizziness, palpitations, insomnia, menstrual disorders, irregular menstruation, chronic uterine bleeding, infertility, restless fetus, miscarriage, and postpartum issues. It is also used for soreness and weakness of the low back and knees, vertigo, tinnitus, hearing loss, tidal fever, night sweats, cough, wheezing, and frequent urination. This herb is used to replenish vital energy, also called “Jing” in Chinese. Jing depletion symptoms include premature gray hair, forgetfulness, blurry vision, impotence, and developmental delay in children.

This herb is cautioned in patients with slow digestion, excess mucus, or stagnation. It is often used with Dang Gui¹³.”

Build Blood Herb #3: Ligusticum Root, Chinese name: Chuan Xiong
“Ligusticum is characterized as sweet and warm. This herb is used to activate life energy (Qi) and blood circulation. It is used to treat gynecological disorders, irregular menstruation, amenorrhea, dysmenorrhea, difficult labor, postpartum bleeding, abdominal pain with chest and gastric distention, stabbing pain in the chest and abdomen, angina, bone spurs, numbness and paralysis of the extremities, traumatic injury pain, non-healing ulcers and sores, headaches, cerebral thrombosis, cerebral embolism, trigeminal nerve pain, and musculo-skeletal and joint pain.

Ligusticum has been found to: lower blood pressure, increase blood perfusion, have a marked antiplatelet and anticoagulation effect, reduce brain swelling, sedate the central nervous system in animal studies, and have a protective effect against radiation in animal studies. It has been used to treat cerebral ischemia, Alzheimer’s disease, and migraine headache.

This herb is contraindicated in patients with heat signs, dry mouth, and a red tongue. It is used with caution in cases of hypermenorrhea. It is suggested that ligusticum may potentiate the effects of anticoagulant or antiplatelet drugs. This herb is often used in combination with Dang Gui and rehmannia¹⁴.”

Build Blood Herb #4: Polygonum multiflorum, Chinese name: He Shou Wu
This herb also has an unusual story associated with it. “A man named Neng Si was born chronically weak. He had never married and gave up on having children. He enthusiastically followed a Taoist teacher who lived on a mountain. After falling into a drunken stupor in the forest, he awoke and found a pair of vines entwined together. He dug up the root of the plant, which he showed to a hermit from the mountain who told him to take it. He swallowed a small amount each day. In seven days, he started to feel an unknown vitality flowing through his veins. He could barely control his new found sexual desire. Over the next several years he became strong, his hair grew dark again, and he eventually fathered several boys¹⁵.”

“The characteristics of this herb are sweet, bitter, astringent, and slightly warm. It is used to replenish Jing or vital energy, nourish the blood of the liver and kidneys, eliminate toxins, treat malarial disorders, moisten the intestines and unblock bowels, and lower cholesterol and treat cardiovascular disorders. This herb is especially used with patients with anemia, postpartum women, the elderly, and people that are recovering from a chronic illness. Polygonum is used to treat dizziness, blurred vision, gray hair, soreness and weakness of the low back and knees, early signs of aging, anemia, numbness of the limbs, menstrual disorders, irregular menstruation, abnormal uterine bleeding. It also is used to treat toxic sores, abscesses, scrofula, goiter, neck lumps, non-healing sores, constipation, high cholesterol, angina, coronary heart disease, hypertension, insomnia, schizophrenia, and epigastric pain.

It has also been used to treat malarial toxins and symptoms of fever, chills, weakness, and fatigue. In multiple lab studies, polygonum slows the aging process and increases life expectancy, increases T-lymphocytes, and white blood cells, and increases hormonal secretions by the adrenal and thyroid glands. This herb is used with caution in patients with loose stools or diarrhea. It is contraindicated in patients with excess mucus¹⁶.”

Build Blood Herb #5: White Peony Root, Chinese name: Bai Shao
“The properties of this herb are bitter, sour and cool. White peony is used to strengthen the blood and moisten dryness in the body. This herb treats a dull and pale complexion, dizziness, tinnitus, and brittle, pale nails. White peony regulates menstruation and helps to alleviate pain. It is used to treat these conditions: irregular menstruation, dysmenorrhea, uterine bleeding, breast distention, pre-menstrual symptoms, mood swings, restlessness, and gestational and post-partum disorders. Other conditions treated by this herb include: night sweats, spontaneous sweating, and excessive perspiration.

White peony is also used to treat long standing pathogenic illnesses with symptoms of muscle spasms, twitches, tremors, alternating flexion and extension of the extremities, tonic-clonic spasms, and convulsions. It is also used to treat excess heat conditions marked by dizziness, tinnitus, flushed face, red eyes, irritability, bad temper, headache, vertigo, poor balance, delirium, burning diarrhea, burning upon urination, and loss of consciousness. White peony is also used to treat numbness, spasms, and pain in the muscles, tendons, sinews, and extremities. It is also used for epigastric, intercostal, flank, hypochondriac, and abdominal pain.

This herb is contraindicated in patients with eczema or rashes that are aggravated by wind. It is also contraindicated in post-partum patients with stabbing fixed pains or who are still bleeding. White peony may cause drowsiness or sedation. People who operate heavy machinery need to exercise caution.

White peony has an inhibitory effect against Bacillus dysenteriae, E. coli, Salmonella typhi, Pseudonomas aeruginosa, Staphylococcus aureus, Beta-hemolytic streptococcus, Diplococcus pneumoniae, and some dematophytes¹⁷.”

The proper combination of liposomal blood building herbs can help to relieve persistent fatigue, memory problems, shortness of breath associated with anemia caused by co-infections. These herbs can be used simultaneously during antibiotic therapy.

Blood building and invigorating herbs can help relieve persistent anemia fatigue and cognitive problems
Let’s go back to the potatoes in the garden. Next season, I found out that putting chicken wire around the potato bed was able to keep out tunneling potato pests. Just like potatoes protected by a fence, a combination of liposomal blood building and invigorating herbs helped Ivan to protect and maintain his red blood cell count. As a result, he felt more energized, had a healthier skin color, and enjoyed greater mental clarity on his job. Since some of these remedies have cautions and contraindications, work with a Lyme literate Chinese medicine practitioner to develop a proper, safe, and effective strategy for your condition.

– Greg

>> Next step: Come to our evening lecture:  Getting Rid of Lyme Disease in Frederick, Maryland on Monday July 6th at 6pm to learn more about reversing anemia, Lyme adrenal fatigue, electrodermal scanning for hidden infections, natural methods for reducing neurological Lyme, inflammation, and pain caused by protozoa, co-infections, and yeast.  https://goodbyelyme.com/events/get_rid_lyme

P.S. Do you have experiences where  remedies, or treatments helped to reverse anemia symptoms caused by Babesia, Bartonella, or Mycoplasma? Tell us about it.

1. Leonard, Alecia J., Kerry A. Chalmers, Clare E. Collins, and Amanda J. Patterson. “A Study of the Effects of Latent Iron Deficiency on Measures of Cognition: A Pilot Randomised Controlled Trial of Iron Supplementation in Young Women.” Nutrients 6, no. 6 (June 23, 2014): 2419–35. doi:10.3390/nu6062419. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073160/
2 Bangirana, Paul, Robert O. Opoka, Michael J. Boivin, Richard Idro, James S. Hodges, Regilda A. Romero, Elsa Shapiro, and Chandy C. John. “Severe Malarial Anemia Is Associated with Long-Term Neurocognitive Impairment.” Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 59, no. 3 (August 1, 2014): 336–44. doi:10.1093/cid/ciu293. https://www.ncbi.nlm.nih.gov/pubmed/24771329
3 Wormser, Gary P., Aakanksha Prasad, Ellen Neuhaus, Samit Joshi, John Nowakowski, John Nelson, Abraham Mittleman, Maria Aguero-Rosenfeld, Jeffrey Topal, and Peter J. Krause. “Emergence of Resistance to Azithromycin-Atovaquone in Immunocompromised Patients with Babesia Microti Infection.” Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 50, no. 3 (February 1, 2010): 381–86. doi:10.1086/649859. https://www.ncbi.nlm.nih.gov/pubmed/20047477
4 Biswas, Silpak, Ricardo G. Maggi, Mark G. Papich, and Edward B. Breitschwerdt. “Molecular Mechanisms of Bartonella Henselae Resistance to Azithromycin, Pradofloxacin and Enrofloxacin.” The Journal of Antimicrobial Chemotherapy 65, no. 3 (March 2010): 581–82. doi:10.1093/jac/dkp459. https://www.ncbi.nlm.nih.gov/pubmed/20022937
5 Biswas, S., D. Raoult, and J.-M. Rolain. “Molecular Mechanism of Gentamicin Resistance in Bartonella Henselae.” Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 15 Suppl 2 (December 2009): 98–99. doi:10.1111/j.1469-0691.2008.02178.x. https://www.ncbi.nlm.nih.gov/pubmed/20584166
6 Biswas, S., D. Raoult, and J.-M. Rolain. “Molecular Characterisation of Resistance to Rifampin in Bartonella Quintana.” Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 15 Suppl 2 (December 2009): 100–101. doi:10.1111/j.1469-0691.2008.02179.x. https://www.ncbi.nlm.nih.gov/pubmed/19929979
7 Del Valle, Luis J., Lidia Flores, Martha Vargas, Ruth García-de-la-Guarda, Ruth L. Quispe, Zoila B. Ibañez, Débora Alvarado, Pablo Ramírez, and Joaquim Ruiz. “Bartonella Bacilliformis, Endemic Pathogen of the Andean Region, Is Intrinsically Resistant to Quinolones.” International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases 14, no. 6 (June 2010): e506–10. doi:10.1016/j.ijid.2009.07.025. https://www.ncbi.nlm.nih.gov/pubmed/19969497
8 Angelakis, Emmanouil, Didier Raoult, and Jean-Marc Rolain. “Molecular Characterization of Resistance to Fluoroquinolones in Bartonella Henselae and Bartonella Quintana.” The Journal of Antimicrobial Chemotherapy 63, no. 6 (June 2009):
1288–89. doi:10.1093/jac/dkp133. https://www.ncbi.nlm.nih.gov/pubmed/19369272
9 Ji, Misuk, Nam-Sihk Lee, Ji-Min Oh, Ji Yoon Jo, Eun Hwa Choi, Soo Jin Yoo, Hyo-Bin Kim, et al. “Single-Nucleotide Polymorphism PCR for the Detection of Mycoplasma Pneumoniae and Determination of Macrolide Resistance in Respiratory Samples.” Journal of Microbiological Methods 102 (July 2014): 32–36. doi:10.1016/j.mimet.2014.04.009. https://www.ncbi.nlm.nih.gov/pubmed/24780151
10 Moles, Ernest, Patricia Urbán, María Belén Jiménez-Díaz, Sara Viera-Morilla, Iñigo Angulo-Barturen, Maria Antònia Busquets, and Xavier Fernàndez-Busquets. “Immunoliposome-Mediated Drug Delivery to Plasmodium-Infected and Non-Infected Red Blood Cells as a Dual Therapeutic/prophylactic Antimalarial Strategy.” Journal of Controlled Release: Official Journal of the Controlled Release Society 210 (May 23, 2015): 217–29. doi:10.1016/j.jconrel.2015.05.284. https://www.ncbi.nlm.nih.gov/pubmed/26008752
11 Foster, Steven, and Yue Chongxi. Herbal Emissaries: Bringing Chinese Herbs to the West: A Guide to Gardening, Herbal Wisdom, and Well-Being. Inner Traditions / Bear & Co, 1992. P. 65. https://www.amazon.com/Herbal-Emissaries-Steven-Foster/dp/0892813490
12. Chen, John K., Tina T. Chen, and Laraine Crampton. Chinese Medical Herbology and Pharmacology. Art of Medicine Press, 2004. pp. 918-923.
13. Chen, John K., Tina T. Chen, and Laraine Crampton. Chinese Medical Herbology and Pharmacology. Art of Medicine Press, 2004. pp. 924-927.
14. Chen, John K., Tina T. Chen, and Laraine Crampton. Chinese Medical Herbology and Pharmacology. Art of Medicine Press, 2004. pp. 614-617.
15. He Shou Wu. https://www.dragonherbs.com/prodinfo.asp?number=542
16. Chen, John K., Tina T. Chen, and Laraine Crampton. Chinese Medical Herbology and Pharmacology. Art of Medicine Press, 2004. pp. 927-929.
17. Chen, John K., Tina T. Chen, and Laraine Crampton. Chinese Medical Herbology and Pharmacology. Art of Medicine Press, 2004. pp. 930-934.

Image credit: “Sweet potatoes” by (c) 2005 Jérôme SAUTRET –
image by myself. Licensed under CC BY-SA 3.0 via Wikimedia Commons – https://commons.wikimedia.org/wiki/File:Sweet_potatoes.JPG#/media/File:Sweet_potatoes.JPG

DISCLAIMER:-

The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-practitioner relationship, and should not be used as a substitute for professional diagnosis and treatment.

Please consult your health care provider, or contact the Two Frogs Healing Center for an appointment, before making any healthcare decisions or for guidance about a specific medical condition. The Two Frogs Healing Center expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. The Two Frogs Healing Center does not endorse specifically any test, treatment, or procedure mentioned on the site.

By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by the Two Frogs Healing Center. If you do not agree to the foregoing terms and conditions, you should not enter this site.

For people with Lyme disease that have a mid-afternoon drop in their energy, can’t get out of bed, or are depleted after Lyme disease treatment
by Greg Lee

Driving back from my local IKEA store, my car started to shake, sputter, and slow down. My anxiety levels started to rise as I realized I was in a part of town with a lot of crime. The thought of criminals seeing my broken down car with a big furniture box on top, left me feeling vulnerable like a defenseless deer in mountain lion country. As my friend and I were coasting to a stop, he shouted, “Get off here!” We got off onto an exit ramp. At the end of the ramp, I felt a wave of relief as we slowly came to a stop right in front of a guardhouse of a massive military base.

How is a broken down car similar to adrenal fatigue caused by a Lyme disease infection?

Just like a stalled car on the side of the road, Lyme disease can leave you feeling exhausted
Bonnie would feel like taking a nap every afternoon at work around 3 pm. On weekends she would sleep twelve or more hours to catch up on her rest. Unfortunately, it would take more and more caffeine to boost her energy temporarily. After a demanding family gathering, she crashed and couldn’t get out of bed for two days. Her doctor diagnosed her with fatigue and told her to get more rest. She decided to get another opinion.

Various medications, supplements and treatments gave her some more energy
Chiropractic adjustments, acupuncture, and green smoothies brought some relief, however her fatigue would quickly return. After many months, her doctor gave her the diagnosis of chronic fatigue syndrome and prescriptions for steroids and antidepressants. These medications helped a little. For several years afterwards, Bonnie just took the medications and still struggled with her fatigue. Fortunately, she heard about a Lyme literate acupuncturist two hours away. She received a new type of scan that checks for electrical frequencies of different infections.

Electro-dermal scanning technology helped to discover the underlying factors in persistent fatigue
Bonnie received an electro-dermal scan that checked different systems of her body for illness, infections, and possible remedies. The scan identified elevated frequencies corresponding to neurological Lyme disease, protozoa in her digestion tract, and adrenal depletion. Her 23andMe genetic report showed a mutation in a gene can decrease enzyme activity and increase fatigue.

Can natural remedies help her to replenishing from Lyme disease and co-infection adrenal fatigue?

Here are four strategies for restoring vitality caused by adrenal fatigue in people with Lyme disease
Given the identified locations of her infections, Bonnie’s treatments and medicines were focused on clearing out her infection from her nervous system and intestines. Protozoa infections like Babesia can move through the blood, so anti-protozoa remedies for clearing infection from her entire body were also used. Given her concerns about antibiotics disrupting her gut health, she chose a natural approach first. A combination of energy replenishing treatments and natural medicines helped to restore her energy.

Strategy #1: Use sublingual essential oils to target central nervous system Lyme
Bonnie received a mixture of essential oils that have inhibited Lyme disease in lab studies: cistus¹ and clove², combined with others including lavender³, and frankincense⁴ to reduce inflammation and protect the nervous system. Every night, she held a few drops under her tongue to allow the oils to diffuse into her nervous system. Within a few days her head felt clearer and she reported sleeping more deeply. Bonnie also took liposomal remedies to target toxins and infections in her body.

Strategy #2: Take liposomal remedies to detoxify and reduce infections
In animal studies, a simultaneous Lyme disease and a protozoa infection decreases immune response and increases mortality rates in mice⁵. Liposomal remedies are extremely small natural medicines which are covered in lecithin. Cells easily absorb liposomes because of their size and lecithin covering. Bonnie took a customized liposomal mixture of glutahione⁶ and vitamin C⁷ to help reduce toxins and inflammatory compounds that produce fatigue.  She also took liposomal herbs that inhibit leptospirosis⁸, another spirochete infection, and protozoa in different experiments: artemisia annua⁹, andrographis which contains andrographolide¹⁰, scutellaria and coptis¹¹, scrophulariiflora¹², and achyranthes¹³. In patients infected with Lyme disease and co-infections, liposomal herbal formulas have been highly effective at increasing stamina and energy levels compared to herbs in alcohol tinctures, decoctions, or powdered herbs. Frequency Specific Microcurrent treatments also help to target infections, reduce toxicity, and increase vitality.

Strategy #3: Apply Frequency Specific Microcurrent to reduce infections and compounds that deplete energy reserves
Frequency Specific Microcurrent treatments sends a pair of low level electrical currents, referred to as A/B, into the body to inhibit infection, reduce toxicity and inflammation, and increase vitality¹⁴. The “A” current was delivered into Bonnie to inhibit spirochetes (20, 45, 47), protozoa (32, 113), infectious toxins (spirochete 55/00, protozoa 60/30). The “B” current pair was used to target the central nervous system (1, 89, 94), the digestion tract (22, 31, 85). She also received frequencies to revitalize her adrenals (49, 81 / 273, 315). Bonnie felt much more replenished and energized after receiving microcurrent treatment. Taking remedies to increase energy also helped.

Strategy #4: Take remedies for replenishing vitality
In Chinese medicine, there are herbs which are used to replenish kidney essence, also know as Jing¹⁵. Bonnie took a liposomal herbal combination which had several jing nourishing herbs including lycii berries¹⁶, cooked rehmannia¹⁷,  eucommia¹⁸, cornus¹⁹, and cordyceps mushroom²⁰. She also took a supplement for addressing genetic problems affecting enzyme activity and replenishes mitochondrial energy. She felt a difference in her symptoms soon after getting treatments, taking her remedies, and sleeping more deeply.

Bonnie felt an increase in energy in a few short days
Four days after her first treatment, Bonnie did not feel like taking an afternoon nap. She even made plans to go out with friends on the weekend. Despite the unusual taste, she was extremely pleased to see how liposomal remedies, essential oils and energy replenishing herbs worked at giving her more vitality.  A combination of these four strategies can help you replenish from Lyme adrenal fatigue.

These four strategies help to stop the energy drain from a Lyme disease and protozoa infection
Let’s go back to my stalled car. It turns out that I just ran out of gas and we got back on the road in a short time. Just like putting gas in the tank, electro-dermal testing helps to identify which infections may be the biggest energy suckers. Liposomal remedies can be used to reduce the underlying infections, toxins, and inflammation. In Bonnie’s case, sublingual essential oils, liposomal remedies, Frequency Specific Microcurrent, and energy replenishing herbs all worked together to help her to stop feeling exhausted and regain her vitality back. Since some of these herbs and essential oils have cautions on their use, work with a Lyme literate herbalist that understands the proper use of liposomal remedies to develop an effective, safe, and targeted strategy for your condition.

– Greg

>> Next step: Come to our evening lecture:  Getting Rid of Lyme Disease in Frederick, Maryland on Monday June 1st at 6pm to learn more about reversing Lyme adrenal fatigue, electrodermal scanning for hidden infections, natural methods for reducing neurological Lyme, inflammation, and pain caused by protozoa, co-infections, and yeast.  https://goodbyelyme.com/events/get_rid_lyme

P.S. Do you have experiences where essential oils, natural remedies, or treatments helped to restore your energy from Lyme adrenal fatigue? Tell us about it.

1. Hutschenreuther, A., C. Birkemeyer, K. Grötzinger, R. K. Straubinger, and H. W. Rauwald. “Growth Inhibiting Activity of Volatile Oil from Cistus Creticus L. against Borrelia Burgdorferi S.s. in Vitro.” Die Pharmazie 65, no. 4 (April 2010): 290–95. https://www.ncbi.nlm.nih.gov/pubmed/20432627
2. Sapi, E. Private conversation. Lyme Disease Association/Columbia University Scientific Conference, October 3, 2010.
3. Hancianu, Monica, Oana Cioanca, Marius Mihasan, and Lucian Hritcu. “Neuroprotective Effects of Inhaled Lavender Oil on Scopolamine-Induced Dementia via Anti-Oxidative Activities in Rats.” Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 20, no. 5 (March 15, 2013): 446–52. doi:10.1016/j.phymed.2012.12.005. https://www.ncbi.nlm.nih.gov/pubmed/23351960
4. Siddiqui, M. Z. “Boswellia Serrata, a Potential Antiinflammatory Agent: An Overview.” Indian Journal of Pharmaceutical Sciences 73, no. 3 (May 2011): 255–61. doi:10.4103/0250-474X.93507. https://www.ncbi.nlm.nih.gov/pubmed/22457547

5. Normark, Johan, Maria Nelson, Patrik Engström, Marie Andersson, Rafael Björk, Thomas Moritz, Anna Fahlgren, and Sven Bergström. “Maladjusted Host Immune Responses Induce Experimental Cerebral Malaria-like Pathology in a Murine Borrelia and Plasmodium Co-Infection Model.” PloS One 9, no. 7 (2014): e103295. doi:10.1371/journal.pone.0103295. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116174/

6. Rotman, Maarten, Mick M. Welling, Anton Bunschoten, Maaike E. de Backer, Jaap Rip, Rob J. A. Nabuurs, Pieter J. Gaillard, Mark A. van Buchem, Silvère M. van der Maarel, and Louise van der Weerd. “Enhanced Glutathione PEGylated Liposomal Brain Delivery of an Anti-Amyloid Single Domain Antibody Fragment in a Mouse Model for Alzheimer’s Disease.” Journal of Controlled Release: Official Journal of the Controlled Release Society 203 (April 10, 2015): 40–50. doi:10.1016/j.jconrel.2015.02.012. https://www.ncbi.nlm.nih.gov/pubmed/25668771

7. Ditteová, G., S. Velebný, and G. Hrckova. “Modulation of Liver Fibrosis and Pathophysiological Changes in Mice Infected with Mesocestoides Corti (M. Vogae) after Administration of Glucan and Liposomized Glucan in Combination with Vitamin C.” Journal of Helminthology 77, no. 3 (September 2003): 219–26. doi:10.1079/JOH2002161. https://www.ncbi.nlm.nih.gov/pubmed/12895280

8. Dharmananda, S. Lyme Disease: Treatment with Chinese Herbs https://www.itmonline.org/arts/lyme.htm

9. Rasoanaivo, Philippe, Colin W Wright, Merlin L Willcox, and Ben Gilbert. “Whole Plant Extracts versus Single Compounds for the Treatment of Malaria: Synergy and Positive Interactions.” Malaria Journal 10, no. Suppl 1 (March 15, 2011): S4. doi:10.1186/1475-2875-10-S1-S4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059462/

10. Sinha, J., S. Mukhopadhyay, N. Das, and M. K. Basu. “Targeting of Liposomal Andrographolide to L. Donovani-Infected Macrophages in Vivo.” Drug Delivery 7, no. 4 (December 2000): 209–13. doi:10.1080/107175400455137. https://www.ncbi.nlm.nih.gov/pubmed/11195427

11. Yabu, Y., M. Nose, T. Koide, N. Ohta, and Y. Ogihara. “Antitrypanosomal Effects of Traditional Chinese Herbal Medicines on Bloodstream Forms of Trypanosoma Brucei Rhodesiense in Vitro.” The Southeast Asian Journal of Tropical Medicine and Public Health 29, no. 3 (September 1998): 599–604. https://www.ncbi.nlm.nih.gov/pubmed/10437965

12. Wang, Hongmin, Weimin Zhao, Vanida Choomuenwai, Katherine T. Andrews, Ronald J. Quinn, and Yunjiang Feng. “Chemical Investigation of an Antimalarial Chinese Medicinal Herb Picrorhiza Scrophulariiflora.” Bioorganic & Medicinal Chemistry Letters 23, no. 21 (November 1, 2013): 5915–18. doi:10.1016/j.bmcl.2013.08.077. https://www.ncbi.nlm.nih.gov/pubmed/24035096

13. Zhu, Xiaotong, Yanyan Pan, Li Zheng, Liwang Cui, and Yaming Cao. “Polysaccharides from the Chinese Medicinal Herb Achyranthes Bidentata Enhance Anti-Malarial Immunity during Plasmodium Yoelii 17XL Infection in Mice.” Malaria Journal 11 (2012): 49. doi:10.1186/1475-2875-11-49. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312874/

14.  McMakin C. Frequency Specific Microcurrent in Pain Management. Edinburgh: Churchill Livingstone/Elsevier; 2011.

15. “Jing (Chinese Medicine).” Wikipedia, the Free Encyclopedia, May 4, 2015. https://en.wikipedia.org/w/index.php?title=Jing_(Chinese_medicine)&oldid=660698341. 

16. Dharmananda, S. Lycium Fruit: Food and Medicine. https://www.itmonline.org/arts/lycium.htm

17. Dharmananda, S. Rehmannia. https://www.itmonline.org/arts/rehmann.htm

18. Dharmananda, S. Eucommia: A Unique Rubber Tree. https://www.itmonline.org/arts/eucommia.htm

19. Dharmananda, S. Cornus. https://www.itmonline.org/arts/cornus.htm

20. Zhang, Hong Wei, Zhi Xiu Lin, Yuk Stewart Tung, Tze Hoi Kwan, Chun Keung Mok, Connie Leung, and Lai Sum Chan. “Cordyceps Sinensis (a Traditional Chinese Medicine) for Treating Chronic Kidney Disease.” The Cochrane Database of Systematic Reviews 12 (2014): CD008353. doi:10.1002/14651858.CD008353.pub2. https://www.ncbi.nlm.nih.gov/pubmed/25519252

Image courtesy of By Riley from Christchurch, New Zealand (1992 Volkswagen Citi Golf) [CC BY 2.0 (https://creativecommons.org/licenses/by/2.0)], via Wikimedia Commons

DISCLAIMER:-

The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-practitioner relationship, and should not be used as a substitute for professional diagnosis and treatment.

Please consult your health care provider, or contact the Two Frogs Healing Center for an appointment, before making any healthcare decisions or for guidance about a specific medical condition. The Two Frogs Healing Center expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. The Two Frogs Healing Center does not endorse specifically any test, treatment, or procedure mentioned on the site.

By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by the Two Frogs Healing Center. If you do not agree to the foregoing terms and conditions, you should not enter this site.

For people with Lyme disease who have recurring bladder discomfort, frequent urination, and anxiety about going to the bathroom
by Greg Lee

I grew up with lots of guinea pigs. Once, a tiny baby piglet crawled under a big heavy sofa. I tried coaxing him out by calling his name, dangling a long piece of grass in front of him, and bringing one of the other piglets nearby. No matter what I did, he stayed under the sofa. What finally got him out was taking a plastic bag with lettuce inside and making a crinkling sound. All the other guinea pigs squeaked loudly thinking they were about to get fed. He ran out lightning quick to see what the fuss was about.

How is a guinea pig hiding under a sofa like a person with recurring discomfort and inflammation in their bladder?

Similar to a hiding guinea pig, inflammation and discomfort can be very difficult to pull out of the bladder
People with recurring urinary tract infections (UTIs) can have symptoms of fatigue, chronic pubic pain, loss of appetite, malaise, pain during urination, copious amounts of urine, urinary incontinence, painful intercourse, urinary urgency, burning sensations in the lower pelvic area with stabbing-like pain, blood in the urine, depression, anxiety, and constipation¹. Underlying reasons for recurring bladder discomfort and pain remain elusive. Urine cultures have detected E. Coli² in some UTI patients. Chlamydia pneumoniae and Lyme disease are also suspected infections which can cause painful bladder symptoms people with interstitial cystitis³. Some patients have struggled for years with persistent bladder discomfort.

Carla’s changed her diet drastically to limit bladder discomfort
Carla avoided foods that triggered symptoms at all costs. When ever she went out to eat, she would avoid eating tomatoes, spicy foods, citrus, sweetened and processed foods. She never drank coffee, sodas, or alcohol. Her friends made fun of her for asking the waiter about the ingredients in her meal. They eventually stopped inviting her out to social events. She would spend hours and hours searching online for the latest research and treatments for reducing bladder discomfort. She read about the inflammatory compounds that get elevated in human and animal studies on bladder pain and interstitial cystitis.

In one study, bladder pain patients had elevated TGF-beta, decorin (a proteoglycan of chondroitin/dermatan sulfate), fibronectin and hyaluronic acid⁴. In animal interstitial cystitis experiments, IL-1α, IL-1β, and TNF-α were elevated⁵. Medications have been effective in a limited number of cases.

Only two medications are approved for treating chronic bladder pain
The first is oral pentosan polysulfate. The other treatment is to place dimethyl sulfoxide into the bladder through a catheter. These treatments have been effective in approximately 30 – 60% of patients. It can have unfavorable side effects, including nausea, diarrhea, gastric distress, and hair loss. Other treatments may include procedures, such as hydrodistention, and oral pharmaceutical drugs, such as antihistamines, tricyclic antidepressants, and immune modulators⁶. There are multiple factors behind why treatment has a low success rate.

Underlying bladder infections can be hidden which makes detection difficult
One theory for the difficulty in detecting underlying infections in recurring bladder pain is biofillms⁷. Biofilms are basically a slime that infections can hide under which reduces the likelihood of detection. Biofilms can harbor multiple infections⁸ which may lead to increased inflammation and pain in the bladder wall. Another reason is drug resistance. E. Coli that are antibiotic resistant⁹ have been found in urine culture tests. Biofilms can also increase drug resistance as high as one-thousand fold¹⁰. Chronic bladder pain patients have also tested positive for Lyme disease.

Lyme disease is found in patients with chronic bladder symptoms
Many patients with chronic bladder pain have also tested positive for Lyme disease and tick co-infections like Bartonella at a medical practice specializing in interstitial cystitis. Also, rare and unusual bacterial and fungal infections have been found by PCR testing in patients after flushing the bladder with an anti-biofilm medication called Ethylenediaminetetraacetic acid (EDTA) via catheter. Broad spectrum antimicrobial remedies delivered via catheter have also been much more effective at relieving bladder discomfort when combined with EDTA¹¹. In another study, catheter delivered hydrocortisone and heparin, along with oral bladder sedatives and systemic steroids provided significant relief¹².

In addition to catheter delivered medications, what else can help you to relieve painful bladder discomfort?

Here are five strategies for relieving chronic bladder pain
There are five strategies that have helped patients to reduce or eliminate persistent bladder discomfort.
● Reduce toxicity and inflammation which aggravate the bladder lining
● Cut through biofilms and kill pathogens
● Heal damage to the bladder
● Improve diet to reduce / eliminate trigger foods
● Get treatments for reducing pain and discomfort

Reducing Bladder Pain Strategy #1: Reduce toxicity and inflammation
Infections in the bladder can trigger the production of inflammation which can lead to pain and discomfort. Neutralizing these inflammatory compounds can help to reduce the irritation in the bladder. There are several herbs and an essential oil that reduce the inflammatory compounds which can aggravate bladder discomfort. A highly effective delivery method is to micronized the herbs into small particles called liposomes. Liposomes are remedies that are wrapped in a layer of fat called a lipid in order to increase their penetration into the bladder. In addition to liposomes, cinnamon essential oil is diluted with a carrier oil at a very low concentration and applied topically to reduce inflammation.

Salvia root, Chinese name: Dan Shen, has been used for over 1900 years. Traditionally, salvia has been used to replenish the blood, move blood stagnation, and reduce inflammation. Modern research in China reports that this herb improves microcirculation of the blood, protects the liver against fibrosis and cirrhosis, and aids in the healing of bone fractures¹³. It has been found to inhibit IL-1α, TNF-α¹⁴, TGF-β1¹⁵, and IL-1β in animal studies¹⁶.

Raw ginger, Chinese name: Sheng Jiang, is used in a wide variety of herbal formulas for treating toxicity, burns, nausea, coldness in the stomach¹⁷, lung phlegm¹⁸, pain¹⁹, alopecia²⁰, rhematoid arthritis, and inflammation²¹. This herb inhibits IL-1α and TNF-α in a human study²². Gingerol, one of the main compounds in raw ginger, inhibits TGF-β in a lab study²³.

Cassia leaf essential oil and the compound cinnamaldehyde inhibits TNF-α and IL-1β in a lab study²⁴. In addition to herbs and supplements, Frequency Specific Microcurrent can help to neutralize toxins and inflammation.

Frequency Specific Microcurrent uses low level electrical currents to reduce pain (20), neutralize toxins (12), reduce biofilms (28) and lower inflammation (284, 82) which are paired with a second current for targeting the urinary system (48), ureter (60), urinary bladder (37) and the bladder sphincter (178)²⁵. Carla noticed significant relief immediately after her microcurrent sessions. In addition to removing toxins and inflammation, cutting through biofilms to get to infections is next.

Reducing Bladder Pain Strategy #2: Disrupt biofilms and kill hidden bladder infections
Biofilms are like a resealable plastic bag. Germs can go in, out, and back into hiding again. If you dissolve the plastic, you can get to the pathogens. Essential oils have compounds called phenols which are solvents that cut through biofilms. Essential oils can be combined in a 1:1 ratio with a carrier oil. This mixture can be used topically to deliver oils into the biofilms and germs in the bladder and urinary tract. Fortunately, liposomal essential oils can penetrate deeper into biofilms, disrupt biofilm formation, and kill the underlying pathogens. Carla said that her liposomal essential oil remedy tasted like a combination of furniture polish and Christmas.

Cinnamon bark oil and its components, cinnamaldehyde and eugenol, inhibit E. Coli biofilm formation in a lab study²⁶. Cinnamon oil is a broad spectrum anti-microbial which has been effective at inhibiting biofilms and the following pathogens from Acinetobacter baumannii²⁷, Candida parapsilosis²⁸, and Staphylococcus epidermidis²⁹. Due to it’s strong nature, low dose cinnamon oils are safest for preventing tissues irritation.

Clary sage, juniper, lemon and marjoram essential oils inhibited biofilm formation around mixed cultures of E. Coli, and other pathogens³⁰.

Tea tree and melissa essential oils inhibited E. Coli and Staph aureus biofilm formation in a lab study³¹. In multiple human, lab and animal studies, tea tree is effective at inhibiting pathogens and their biofilms including Candida³², Staphylococcus aureus³³, Listeria monocytogenes³⁴, and oral biofilms³⁵.

Rose, geranium, lavender, and rosemary essential oils were effective at inhibiting E. coli communication signals for biofilm production called Quorum Sensing³⁶.

Eugenol from clove essential oil and terpinen from tea tree essential oil were highly effective at inhibiting Proteus mirabilis biofilms in a catheter study³⁷. Clove oil disrupts how Pseudomonas aeruginosa and Aeromonas hydrophila communicate to form biofilms in one lab study³⁸. Clove also inhibited biofilm formation and these pathogens in lab studies on Streptococcus pneumoniae³⁹, Enterococcus faecalis⁴⁰, and Candida albicans⁴¹. Due to it’s strong nature, low dose clove oils are safest for preventing bladder irritation.

Reducing Bladder Pain Strategy #3: Heal damage to the bladder
Multiple pathogens in the bladder can trigger the release of the inflammatory compounds. These compounds can irritate and damage the lining of the bladder. Herbs and their constituent compounds have been helpful for preventing or reducing bladder irritation. These herbs are processed into a liposomal form to increase their penetration in the the bladder.

Berberine is a compound found in coptis rhizome, Chinese name: Huang Lian and phellodendron, Chinese name: Huang Bai. In a rat study, berberine completely prevented cyclophosphamide induced bladder edema and hemorrhage. It also dramatically increased nitric oxide (NO) metabolites in urine and plasma⁴². Nitric oxide is an antimicrobial compound produced by the immune system to kill infections.

Astragalus extract, Chinese name: Huang Qi protected mice from urinary bladder carcinoma and lowered interleukin-2 (IL-2) and interferon-gamma (IFN-γ)⁴³.

Maitake mushroom, Chinese name: Zhu Ling reduced recurrence of bladder cancer in a rat and human study. Fifteen out of twenty two patients had no recurrence of bladder cancer⁴⁴.

Magnolia bark, Chinese name: Hou Po inhibited bladder cancer cells and inflammatory compounds in a lab study⁴⁵.

Reducing Bladder Pain Strategy #4: Improve diet to reduce bladder symptoms 
Reduce or avoid foods that increase bladder discomfort: items containing caffeine, citrus juices, tomato products, items containing vinegar, hot peppers, alcohol⁴⁶, citrus fruits, tomatoes, vitamin C, artificial sweeteners, coffee, tea, carbonated and alcoholic beverages, and spicy foods. Increase supplements that improve symptoms: calcium glycerophosphate and sodium bicarbonate⁴⁷.

A combination of parsley and garlic, L-arginine, probiotics, and cranberry tablets reduced bladder pain and discomfort in patients diagnosed with drug resistant E. Coli in their urine test⁴⁸.

Reducing Bladder Pain Strategy #5: Get treatments to reduce inflammation and discomfort
Visceral manipulation is an osteopathic manual manipulation technique which can help release inflammation and reduce pain in tissues and organs⁴⁹. When Carla received visceral treatment, she could feel heat and tenderness being released quickly out of her bladder area. Her discomfort would reduce from an 8 to a 3 out of 10.

Acupuncture uses points that help to release heat and discomfort out of the bladder⁵⁰. A combination of topical essential oils, liposomal herbs and remedies, and treatments can help to significantly reduce the bladder inflammation, discomfort, and symptoms of infection.

Remedies, treatments, and a healthy diet can help to reduce symptoms of bladder discomfort caused by infections hidden under biofilms
Just like finding the right lure to coax a baby guinea pig out of its hiding place, a combination of liposomal herbs, essential oils, supplements, Frequency Specific Microcurrent, acupuncture, visceral manipulation and dietary modifications helped Carla to pull the pain and discomfort out of her bladder. Since some of these remedies and treatments require specialized training, work with a Lyme literate Chinese medicine practitioner to develop a proper, safe, and effective strategy for your condition.

– Greg

P.S. Do you have experiences where treatments or remedies improved your bladder pain, urgency, and anxiety? Tell us about it.

>> Next step: Come to our evening lecture: Getting Rid of Lyme Disease in Frederick, Maryland on Monday May 4th at 6pm to learn more about treatments, essential oils, herbs, and homeopathic remedies for healing bladder pain, leaky gut from Lyme disease, Bartonella, toxoplasmosis, drug resistant arthritis, managing weight issues caused by toxins, reducing brain overwhelm, Epstein-Barr virus, adenovirus, brucellosis, Babesia, mold, parasites, abnormal fatigue, and pain.  https://goodbyelyme.com/events/get_rid_lyme

1. Mansour, Anthony, Essa Hariri, Samar Shelh, Ralph Irani, and Mohamad Mroueh. “Efficient and Cost-Effective Alternative Treatment for Recurrent Urinary Tract Infections and Interstitial Cystitis in Women: A Two-Case Report.” Case Reports in Medicine 2014 (2014). doi:10.1155/2014/698758. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283390/
2. Mansour, A., et. Al. “Efficient and Cost-Effective Alternative Treatment for Recurrent Urinary Tract Infections and Interstitial Cystitis in Women: A Two-Case Report.”
3. Cohan, W. The Better Bladder Book: A Holistic Approach to Healing Interstitial Cystitis & Chronic Pelvic Pain. Alameda: Hunter House, Inc. https://www.amazon.com/The-Better-Bladder-Book-Interstitial-ebook/dp/B004R9PZNW
4. Lucon, Marcos, João Roberto Martins, Katia Ramos Moreira Leite, Roberto Soler, Helena B. Nader, Miguel Srougi, and Homero Bruschini. “Evaluation of the Metabolism of Glycosaminoglycans in Patients with Interstitial Cystis.” International Braz J Urol: Official Journal of the Brazilian Society of Urology 40, no. 1 (February 2014): 72–79. https://www.ncbi.nlm.nih.gov/pubmed/24642152
5. Tambaro, Simone, Maria Antonietta Casu, Andrea Mastinu, and Paolo Lazzari. “Evaluation of Selective Cannabinoid CB(1) and CB(2) Receptor Agonists in a Mouse Model of Lipopolysaccharide-Induced Interstitial Cystitis.” European Journal of Pharmacology 729 (April 15, 2014): 67–74. doi:10.1016/j.ejphar.2014.02.013. https://www.ncbi.nlm.nih.gov/pubmed/24561047
6. Fiehn, Oliver, and Jayoung Kim. “Metabolomics Insights Into Pathophysiological Mechanisms of Interstitial Cystitis.” International Neurourology Journal 18, no. 3 (September 2014): 106–14. doi:10.5213/inj.2014.18.3.106. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180160/
7. Graziottin, A., P. P. Zanello, and G. D’Errico. “[Recurrent cystitis and vaginitis: role of biofilms and persister cells. From pathophysiology to new therapeutic strategies].” Minerva Ginecologica 66, no. 5 (October 2014): 497–512. https://www.ncbi.nlm.nih.gov/pubmed/25245998
8. Burmølle, Mette, Trine Rolighed Thomsen, Mustafa Fazli, Irene Dige, Lise Christensen, Preben Homøe, Michael Tvede, et al. “Biofilms in Chronic Infections – a Matter of Opportunity – Monospecies Biofilms in Multispecies Infections.” FEMS Immunology and Medical Microbiology 59, no. 3 (August 2010): 324–36. doi:10.1111/j.1574-695X.2010.00714.x. https://www.ncbi.nlm.nih.gov/pubmed/20602635
9. Mansour, A., et. Al. “Efficient and Cost-Effective Alternative Treatment for Recurrent Urinary Tract Infections and Interstitial Cystitis in Women: A Two-Case Report.”
10. Sriramulu, Dinesh. “Evolution and Impact of Bacterial Drug Resistance in the Context of Cystic Fibrosis Disease and Nosocomial Settings.” Microbiology Insights 6 (April 14, 2013): 29–36. doi:10.4137/MBI.S10792. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987750/
11. Private conversation with R. Kriz. March 15, 2015.
12. Taneja, Rajesh, and Kailash K. Jawade. “A Rational Combination of Intravesical and
Systemic Agents for the Treatment of Interstitial Cystitis.” Scandinavian Journal of Urology and Nephrology 41, no. 6 (2007): 511–15. doi:10.1080/00365590701435918. https://www.ncbi.nlm.nih.gov/pubmed/17853025
13. Dharmananda, S. Salvia and the History of Microcirculation Research in China. https://www.itmonline.org/arts/salvia.htm
14. Zhang, Ying, Yuanyuan Zhang, Yun Xie, Yonggang Gao, Juanjuan Ma, Jie Yuan, Juan Li, et al. “Multitargeted Inhibition of Hepatic Fibrosis in Chronic Iron-Overloaded Mice by Salvia Miltiorrhiza.” Journal of Ethnopharmacology 148, no. 2 (July 9, 2013): 671–81. doi:10.1016/j.jep.2013.05.028. https://www.ncbi.nlm.nih.gov/pubmed/23707206
15. Lee, Hak Sung, Woo-Chan Son, Jae-Eun Ryu, Bon Am Koo, and Yeong Shik Kim. “Standardized Salvia Miltiorrhiza Extract Suppresses Hepatic Stellate Cell Activation and Attenuates Steatohepatitis Induced by a Methionine-Choline Deficient Diet in Mice.” Molecules (Basel, Switzerland) 19, no. 6 (2014): 8189–8211. doi:10.3390/molecules19068189. https://www.ncbi.nlm.nih.gov/pubmed/24941342
16. Xiping, Zhang, Pan Yan, Huang Xinmei, Feng Guanghua, Ma Meili, Ni Jie, and Zhang Fangjie. “Effects of Dexamethasone and Salvia Miltiorrhizae on the Small Intestine and Immune Organs of Rats with Severe Acute Pancreatitis.” Inflammation 33, no. 4 (August 2010): 259–66. doi:10.1007/s10753-010-9180-9. https://www.ncbi.nlm.nih.gov/pubmed/20127399
17. Dharmananda, S. Countering the Side Effects of Modern Medical Therapies With Chinese Herbs. https://www.itmonline.org/arts/sidefx.htm
18. Dharmananda, S. A Study Guide to Phlegm-Resolving Herbs. https://www.itmonline.org/arts/phlegm.htm
19. Dharmananda, S. Safety Issues Affecting Chinese Herbs: The Case of Ma-huang. https://www.itmonline.org/arts/mahuang.htm
20. Dharmananda, S. Treatment of Alopecia With Chinese Herbs. https://www.itmonline.org/arts/alopecia.htm
21. Dharmananda, An Analysis of Chinese Herb Prescriptions for Rheumatoid Arthritis. https://www.itmonline.org/arts/arthritis.htm
22. Percival, Susan S., John P. Vanden Heuvel, Carmelo J. Nieves, Cindy Montero, Andrew J. Migliaccio, and Joanna Meadors. “Bioavailability of Herbs and Spices in Humans as Determined by Ex Vivo Inflammatory Suppression and DNA Strand Breaks.” Journal of the American College of Nutrition 31, no. 4 (August 2012): 288–94. https://www.ncbi.nlm.nih.gov/pubmed/23378457
23. Kamato, Danielle, Hossein Babaahmadi Rezaei, Robel Getachew, Lyna Thach, Daniel Guidone, Narin Osman, Basil Roufogalis, et al. “(S)-[6]-Gingerol Inhibits TGF-Β-Stimulated Biglycan Synthesis but Not Glycosaminoglycan Hyperelongation in Human Vascular Smooth Muscle Cells.” The Journal of Pharmacy and Pharmacology 65, no. 7 (July 2013): 1026–36. doi:10.1111/jphp.12060. https://www.ncbi.nlm.nih.gov/pubmed/23738730
24. Pannee, Chinjarernpan, Itthipanichpong Chandhanee, and Limpanasithikul Wacharee. “Antiinflammatory Effects of Essential Oil from the Leaves of Cinnamomum Cassia and Cinnamaldehyde on Lipopolysaccharide-Stimulated J774A.1 Cells.” Journal of Advanced Pharmaceutical Technology & Research 5, no. 4 (October 2014): 164–70. doi:10.4103/2231-4040.143034. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215479/
25. McMakin C. Frequency Specific Microcurrent in Pain Management. Edinburgh: Churchill Livingstone/Elsevier; 2011.
26. Szabó, Mira Agnes, Gábor Zoltán Varga, Judit Hohmann, Zsuzsanna Schelz, Erno
Szegedi, Leonard Amaral, and József Molnár. “Inhibition of Quorum-Sensing Signals by Essential Oils.” Phytotherapy Research: PTR 24, no. 5 (May 2010): 782–86. doi:10.1002/ptr.3010. https://www.ncbi.nlm.nih.gov/pubmed/25500277
27. Sienkiewicz, Monika, Anna Głowacka, Edward Kowalczyk, Anna Wiktorowska-Owczarek, Marta Jóźwiak-Bębenista, and Monika Łysakowska. “The Biological Activities of Cinnamon, Geranium and Lavender Essential Oils.” Molecules (Basel, Switzerland) 19, no. 12 (2014): 20929–40. doi:10.3390/molecules191220929. https://www.ncbi.nlm.nih.gov/pubmed/25514231
28. Pires, Regina Helena, Lilian Bueno Montanari, Carlos Henrique G. Martins, José Eduardo Zaia, Ana Marisa Fusco Almeida, Marcelo T. Matsumoto, and Maria José S. Mendes-Giannini. “Anticandidal Efficacy of Cinnamon Oil against Planktonic and Biofilm Cultures of Candida Parapsilosis and Candida Orthopsilosis.” Mycopathologia 172, no. 6 (December 2011): 453–64. doi:10.1007/s11046-011-9448-0. https://www.ncbi.nlm.nih.gov/pubmed/21761153
29. Nuryastuti, Titik, Henny C. van der Mei, Henk J. Busscher, Susi Iravati, Abu T. Aman, and Bastiaan P. Krom. “Effect of Cinnamon Oil on icaA Expression and Biofilm Formation by Staphylococcus Epidermidis.” Applied and Environmental Microbiology 75, no. 21 (November 2009): 6850–55. doi:10.1128/AEM.00875-09. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772433/
30. Kerekes, E.-B., É Deák, M. Takó, R. Tserennadmid, T. Petkovits, C. Vágvölgyi, and J. Krisch. “Anti-Biofilm Forming and Anti-Quorum Sensing Activity of Selected Essential Oils and Their Main Components on Food-Related Micro-Organisms.” Journal of Applied Microbiology 115, no. 4 (October 2013): 933–42. doi:10.1111/jam.12289. https://www.ncbi.nlm.nih.gov/pubmed/23789847
31. Budzyńska, Aleksandra, Marzena Wieckowska-Szakiel, Beata Sadowska, Danuta Kalemba, and Barbara Rózalska. “Antibiofilm Activity of Selected Plant Essential Oils and Their Major Components.” Polish Journal of Microbiology / Polskie Towarzystwo Mikrobiologów = The Polish Society of Microbiologists 60, no. 1 (2011): 35–41. https://www.ncbi.nlm.nih.gov/pubmed/21630572
32. De Campos Rasteiro, Vanessa Maria, Anna Carolina Borges Pereira da Costa, Cássia Fernandes Araújo, Patrícia Pimentel de Barros, Rodnei Dennis Rossoni, Ana Lia Anbinder, Antonio Olavo Cardoso Jorge, and Juliana Campos Junqueira. “Essential Oil of Melaleuca Alternifolia for the Treatment of Oral Candidiasis Induced in an Immunosuppressed Mouse Model.” BMC Complementary and Alternative Medicine 14 (2014): 489. doi:10.1186/1472-6882-14-489. https://www.ncbi.nlm.nih.gov/pubmed/25510285
33. Brady, A. J., T. B. Farnan, J. G. Toner, D. F. Gilpin, and M. M. Tunney. “Treatment of a Cochlear Implant Biofilm Infection: A Potential Role for Alternative Antimicrobial Agents.” The Journal of Laryngology and Otology 124, no. 7 (July 2010): 729–38. doi:10.1017/S0022215110000319. https://www.ncbi.nlm.nih.gov/pubmed/20214837
34. Sandasi, M., C. M. Leonard, and A. M. Viljoen. “The in Vitro Antibiofilm Activity of Selected Culinary Herbs and Medicinal Plants against Listeria Monocytogenes.” Letters in Applied Microbiology 50, no. 1 (January 2010): 30–35. doi:10.1111/j.1472-765X.2009.02747.x. https://www.ncbi.nlm.nih.gov/pubmed/19874481
35. Santamaria, Milton, Klodyne Dayana Petermann, Silvia Amélia Scudeler Vedovello, Viviane Degan, Adriana Lucato, and Cristina Maria Franzini. “Antimicrobial Effect of Melaleuca Alternifolia Dental Gel in Orthodontic Patients.” American Journal of Orthodontics and Dentofacial Orthopedics: Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics 145, no. 2 (February 2014): 198–202. doi:10.1016/j.ajodo.2013.10.015. https://www.ncbi.nlm.nih.gov/pubmed/24485734
36. Szabó, Mira Agnes, Gábor Zoltán Varga, Judit Hohmann, Zsuzsanna Schelz, Erno Szegedi, Leonard Amaral, and József Molnár. “Inhibition of Quorum-Sensing Signals by Essential Oils.” Phytotherapy Research: PTR 24, no. 5 (May 2010): 782–86. doi:10.1002/ptr.3010. https://www.ncbi.nlm.nih.gov/pubmed/19827025
37. Malic, Sladjana, Rachael P. C. Jordan, Mark G. J. Waters, David J. Stickler, and David W. Williams. “Biocide Activity against Urinary Catheter Pathogens.” Antimicrobial Agents and Chemotherapy 58, no. 2 (February 2014): 1192–94. doi:10.1128/AAC.01106-13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910826/
38. Husain, Fohad Mabood, Iqbal Ahmad, Mohammad Asif, and Qudsia Tahseen. “Influence of Clove Oil on Certain Quorum-Sensing-Regulated Functions and Biofilm of Pseudomonas Aeruginosa and Aeromonas Hydrophila.” Journal of Biosciences 38, no. 5 (December 2013): 835–44. https://www.ncbi.nlm.nih.gov/pubmed/24296886
39. Yadav, Mukesh Kumar, Seok-Won Park, Sung-Won Chae, Jae-Jun Song, and Ho Chul Kim. “Antimicrobial Activities of Eugenia Caryophyllata Extract and Its Major Chemical Constituent Eugenol against Streptococcus Pneumoniae.” APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica 121, no. 12 (December 2013): 1198–1206. doi:10.1111/apm.12067. https://www.ncbi.nlm.nih.gov/pubmed/23594212
40. Gupta, A., J. Duhan, S. Tewari, P. Sangwan, A. Yadav, G. Singh, R. Juneja, and H. Saini. “Comparative Evaluation of Antimicrobial Efficacy of Syzygium Aromaticum, Ocimum Sanctum and Cinnamomum Zeylanicum Plant Extracts against Enterococcus Faecalis: A Preliminary Study.” International Endodontic Journal 46, no. 8 (August 2013): 775–83. doi:10.1111/iej.12058. https://www.ncbi.nlm.nih.gov/pubmed/23506110
41. Khan, Mohd Sajjad Ahmad, and Iqbal Ahmad. “Biofilm Inhibition by Cymbopogon Citratus and Syzygium Aromaticum Essential Oils in the Strains of Candida Albicans.” Journal of Ethnopharmacology 140, no. 2 (March 27, 2012): 416–23. doi:10.1016/j.jep.2012.01.045. https://www.ncbi.nlm.nih.gov/pubmed/22326355
42. Xu, X., and A. Malavé. “Protective Effect of Berberine on Cyclophosphamide-Induced Haemorrhagic Cystitis in Rats.” Pharmacology & Toxicology 88, no. 5 (May 2001): 232–37. https://www.ncbi.nlm.nih.gov/pubmed/11393582
43. Kurashige, S., Y. Akuzawa, and F. Endo. “Effects of Astragali Radix Extract on Carcinogenesis, Cytokine Production, and Cytotoxicity in Mice Treated with a Carcinogen, N-Butyl-N’-Butanolnitrosoamine.” Cancer Investigation 17, no. 1 (1999): 30–35. https://www.ncbi.nlm.nih.gov/pubmed/10999046
44. Yang, D. A. “[Inhibitory effect of Chinese herb medicine zhuling on urinary bladder cancer. An experimental and clinical study].” Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery] 29, no. 6 (June 1991): 393–95, 399. https://www.ncbi.nlm.nih.gov/pubmed/1935440
45. Lee, Se-Jung, Hong-Man Kim, Young-Hwa Cho, Keerang Park, Eun-Jung Kim, Kyung-Hwan Jung, Cheorl-Ho Kim, Wun-Jae Kim, and Sung-Kwon Moon. “Aqueous Extract of Magnolia Officinalis Mediates Proliferative Capacity, p21WAF1 Expression and TNF-Alpha-Induced NF-kappaB Activity in Human Urinary Bladder Cancer 5637 Cells; Involvement of p38 MAP Kinase.” Oncology Reports 18, no. 3 (September 2007): 729–36. https://www.ncbi.nlm.nih.gov/pubmed/17671727
46. Kuo, Hann-Chorng, Yao-Chi Chuang, and Michael B Chancellor. “Neurourology, Diet, and Painful Bladder.” Reviews in Urology 10, no. 1 (2008): 70–72. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2312345/
47. Friedlander, Justin I., Barbara Shorter, and Robert M. Moldwin. “Diet and Its Role in Interstitial Cystitis/bladder Pain Syndrome (IC/BPS) and Comorbid Conditions.” BJU International 109, no. 11 (June 2012): 1584–91. doi:10.1111/j.1464-410X.2011.10860.x. https://www.ncbi.nlm.nih.gov/pubmed/22233286
48. Mansour, A., et. Al. “Efficient and Cost-Effective Alternative Treatment for Recurrent Urinary Tract Infections and Interstitial Cystitis in Women: A Two-Case Report.”
49. Müller, Axel, Helge Franke, Karl-Ludwig Resch, and Gary Fryer. “Effectiveness of Osteopathic Manipulative Therapy for Managing Symptoms of Irritable Bowel Syndrome: A Systematic Review.” The Journal of the American Osteopathic Association 114, no. 6 (June 2014): 470–79. doi:10.7556/jaoa.2014.098. https://www.ncbi.nlm.nih.gov/pubmed/24917634
50. Alraek, T., and A. Baerheim. “‘An Empty and Happy Feeling in the Bladder.. .’: Health Changes Experienced by Women after Acupuncture for Recurrent Cystitis.” Complementary Therapies in Medicine 9, no. 4 (December 2001): 219–23. doi:10.1054/ctim.2001.0482. https://www.ncbi.nlm.nih.gov/pubmed/12184349

Here’s my dilemma…
In less than two weeks, I’m hosting a live training for medical providers on stopping persistent Lyme Disease. Yikes!

Many of these folks are new to treating Lyme disease. And they want to know:

What are your biggest challenges to healing Lyme disease?

So I thought to ask the experts, which is… You!
Because only you can tell these practitioners the REAL DEAL about the challenges to healing Lyme disease.

So can you do me a favor and take this short survey?

https://www.surveygizmo.com/s3/2103141/2bb149386865

Please go ahead and do this right now, while you’ve got this page open and you are thinking about it.

It takes less than two minutes, and it’ll have a huge impact on how these practitioners help people just like you. In a few weeks, I will share with everyone who fills out the survey the top ten most important challenges submitted. Your personal information will be kept confidential and omitted from the survey results.

Thanks,

Greg

PS. What is it about healing Lyme disease that keeps you up at night? Tell me about it here: https://www.surveygizmo.com/s3/2103141/2bb149386865

For people with Lyme disease who have digestion problems aggravated by antibiotics, poor diet, and gut inflammation
by Greg Lee

– Greg

P.S. Do you have experiences where treatments or remedies improved your abdominal bloating, pain, and distention from Lyme disease leaky gut? Tell us about it.

>> Next step: Come to our evening lecture: Getting Rid of Lyme Disease in Frederick, Maryland on Monday April 6th at 6pm to learn more about treatments, essential oils, herbs, and homeopathic remedies for healing leaku gut from Lyme disease, Bartonella, toxoplasmosis, drug resistant arthritis, managing weight issues caused by toxins, reducing brain overwhelm, Epstein-Barr virus, adenovirus, brucellosis, Babesia, mold, parasites, abnormal fatigue, and pain.  https://goodbyelyme.com/events/get_rid_lyme

For people with Lyme disease that have memory recall issues, word finding problems, and trouble remembering faces
by Greg Lee

Have you ever seen icicles hanging down from the roof? Ice in the gutter blocks water from draining out the downspout. As more water spills over the gutter, it freezes in icicles off the roof. These grow bigger and bigger as sunlight on the roof melts more ice into water which refreezes on the icicles.

How are frozen icicles similar to a Lyme disease infection that prevents memory recall?

Just like water that freezes in a gutter and produces icicles, Lyme bacteria can flood into the brain and freeze memory recall ability
In human and animal studies, Lyme disease have been found to infect the brain and block the ability to access memories. Cognitive impairment with memory and concentration disorders is one of the most frequently cited psychiatric disorders in a twenty year survey of Lyme disease literature^[1]. Lyme neuroborreliosis patients scored lower on processing speed, visual and verbal memory, and executive/attention functions, as compared to matched controls^[2]. In another study, Lyme neuroborreliosis episodes decrease working memory in children^[3]. In a mouse study, exposure to outer surface protein C (OspC) from Lyme leads to axon nerve damage in the brain^[4]. In Alzheimer studies, nerve damage is the leading cause of memory impairment^[5]. Elevated levels of Interferon-alpha (INF-α) have been detected in Lyme patients with persistent memory impairment^[6]. Antibiotics have been able to produce some relief for patients with memory issues.

Intravenous antibiotics have been shown to produce improvements in memory recall issues
Patients given IV ceftriaxone had a greater improvement in their memory issues at the end of three months but unfortunately lost their gains during an antibiotic-free interval of an additional three months out^[7]. In another study of eighteen patients given IV ceftriaxone for Lyme encephalopathy, seven reported a complete recovery of their memory issues and eight reported great improvement^[8]. Unfortunately, many patients with Lyme disease do not have access to medical practitioners that are willing to prescribe IV antibiotics.

What else besides antibiotics can help with treating Lyme induced memory impairment?

Here are four strategies for reducing Lyme disease induced memory impairment
Fortunately, there are liposomal herbs that can help reduce memory impairing inflammatory compounds and help with repairing damaged brain cells. There are also treatments that help to reduce inflammation in the nervous system and revitalize areas of the brain associated with memory.

Memory restoring strategy #1: Liposomal herbal compounds for reducing INF-α
In lab and animal studies, a few anti-inflammatory compounds found in Chinese and South American herbs have inhibited INF-α. Giving these herbs in liposomal remedy provides a more effective delivery method into the brain^[9]. These compounds include: A polysaccharide found in Salvia root, Chinese name: Dan Shen inhibits INF-α in mice^[10]. Extracts containing baicalein and wogonin derived from Scutellaria, Chinese name: Huang Qin inhibits INF-α in one lab study^[11]. Alkaloidal fractions found in Uncaria Tormentosa, Cats Claw inhibited INF-α in another lab study^[12]. INF-α helps with protecting against viral infections, so this approach is cautioned in patients with elevated viral infections. In addition to reducing INF-α, other herbal compounds have been shown to help with repairing nerve damage caused by excess inflammation.

Memory restoring strategy #2: Liposomal herbal compounds for repairing damaged neurons
In lab and animal studies, these herbs and herbal compounds accelerated the regeneration of damaged nerve tissues. Delivering these in a liposomal mixture increases effective delivery into the central nervous system. Reishi mushroom spores, Chinese name Ling Zhi, increased the growth of normal hippocampal neurons in a lab study.^[13] Flavonoid compounds from Epimedium, Chinese name: Yin Yang Huo, increased neural stem cells in one rat study^[14]. A compound called matrine found in Sophora root, Chinese name: Ku Shen, significantly reduced CNS inflammatory demyelination, and axonal damage in a rat study^[15]. Ethanolic extracts of Centella asiatica, Chinese name: Ji Xue Cao, containing asiatic acid and other compounds grew axons at a faster rate than control rats^[16]. A compound called bajijiasu found in Mordina officinalis, Chinese name: Bai Ji Tian, prevented oxygen-deprivation brain damage and death, reversed amyloid-beta (Aβ) induced learning and memory dysfunction, enhanced energy metabolism and neurotransmitter levels in rats^[17]. In a mouse study, a traditional Chinese herbal formula called “Tonify Yang to Restore Five-Tenths Decoction” used for treating stroke symptoms promoted neuronal growth in damaged neurons^[18]. The herbs in this formula are astragalus root, Chinese name: Huang Qi, angelica root, Chinese name: Dang Gui, red peony root, Chinese name: Chi Shao, ligusticum root, Chinese name: Chuan Xiong, safflower, Chinese name: Hong Hua, peach kernel, Chinese name: Tao Ren, and red wiggler or red marsh earthworms, Chinese name: Di Long. Along with herbs, low level electrical frequencies can also target inflammation and enhance repair of damaged nerve cells.

Memory restoring strategy #3: Anti-inflammatory and revitalizing microcurrent frequencies for targeting memory centers of the brain
Frequency Specific Microcurrent uses pairs of extremely minute electrical frequencies which can be configured to improve memory^[19]. The frequency pairs are divided into an “A” frequency and a “B” frequency. The “A” frequency is for producing a healing effect like: reducing inflammation (14, 284), increasing vitality (49, 91), repairing damage (58) or neutralizing toxins (12, 57, 900, 920). The “B” frequency is used to direct healing into a specific area like: nerves (10, 396), the nerve sheath (475), and structures of the brain associated with memory recall. Specific brain structures that are associated with memory are the prefrontal cortex for short-term memory associated with task completion^[20] (983), frontal lobe (90), Broca’s area for verbal memory (90), Wernicke’s area for language recall and auditory memory^[21] (90), central processor^[22] (90), hippocampus for migrating short-term memory to long-term memory (90), visual area for visual memory (84), and Basal ganglia for retrieving procedural memory (988)^[23]. In addition to frequencies, cupping and bloodletting on the head helps with reducing symptoms of brain inflammation.

Memory restoring strategy #4: Cupping and bloodletting on the head to pull out CNS inflammation
Suction cups are placed on the forehead, scalp and neck where there is no hair. The intention of the suction is to draw toxins and inflammation out of the head to the surface. After a few minutes, the cups are removed and the skin is often dark red to purplish in color. Needles are inserted into the area where the cups were located and quickly removed to create holes where blood can be drawn out. The cups are placed back on their original locations. Blood oozes out of the holes and collects into the cups. Often the blood is very thick and coagulates into a jelly-like blob. Analysis of extracted cupping blood has found elevated toxins^[24] and inflammatory compounds^[25]. Cups placed on the occiput have a significant impact on clearing brain fog and improving memory recall. Multiple treatments and remedies can help your nervous system to improve your memory recall ability.

Liposomal remedies and treatments can help to reduce symptoms of memory impairment due to Lyme disease
Just like clearing out the ice that is blocking a gutter, a combination of liposomal anti-inflammatory and neurological repairing remedies, Frequency Specific Microcurrent, cupping and bloodletting can help to reverse the symptoms of memory impairment from Lyme disease. Since some of these remedies and treatments require specialized training, work with a Lyme literate Chinese medicine practitioner to develop a proper, safe, and effective strategy for your condition.

– Greg

P.S. Do you have experiences where treatments or remedies improved your memory impairment from Lyme disease? Tell us about it.

>> Next step: Come to our evening lecture: Getting Rid of Lyme Disease in Frederick, Maryland on Monday March 2nd at 6pm to learn more about treatments, essential oils, herbs, and homeopathic remedies for restoring memory loss from Lyme disease, Bartonella, toxoplasmosis, drug resistant arthritis, managing weight issues caused by toxins, reducing brain overwhelm, Epstein-Barr virus, adenovirus, brucellosis, Babesia, mold, parasites, abnormal fatigue, and pain.  https://goodbyelyme.com/events/get_rid_lyme

^[1] Sno HN. [Signs and significance of a tick-bite: psychiatric disorders associated with Lyme disease]. [Article in Dutch] Tijdschr Psychiatr. 2012;54(3):235-43. https://www.ncbi.nlm.nih.gov/pubmed/22422416

^[2] Eikeland R, Ljøstad U, Mygland A, Herlofson K, Løhaugen GC. European neuroborreliosis: neuropsychological findings 30 months post-treatment. Eur J Neurol. 2012 Mar;19(3):480-7. doi: 10.1111/j.1468-1331.2011.03563.x. Epub 2011 Oct 15. https://www.ncbi.nlm.nih.gov/pubmed/21999112

^[3] Zotter S, Koch J, Schlachter K, Katzensteiner S, Dorninger L, Brunner J, Baumann M, Wolf-Magele A, Schmid H, Ulmer H, Hagspiel S, Rostasy K. Neuropsychological profile of children after an episode of neuroborreliosis. Neuropediatrics. 2013 Dec;44(6):346-53. doi: 10.1055/s-0033-1349724. Epub 2013 Aug 6. https://www.ncbi.nlm.nih.gov/pubmed/23921969

^[4] Tauber SC, Ribes S, Ebert S, Heinz T, Fingerle V, Bunkowski S, Kugelstadt D, Spreer A, Jahn O, Eiffert H, Nau R. Long-term intrathecal infusion of outer surface protein C from Borrelia burgdorferi causes axonal damage. J Neuropathol Exp Neurol. 2011 Sep;70(9):748-57. doi: 10.1097/NEN.0b013e3182289acd. https://www.ncbi.nlm.nih.gov/pubmed/21865883

^[5] Marlatt MW, Lucassen PJ. Neurogenesis and Alzheimer’s disease: Biology and pathophysiology in mice and men. Curr Alzheimer Res. 2010 Mar;7(2):113-25. https://www.ncbi.nlm.nih.gov/pubmed/19860727

^[6] Jacek E, Fallon BA, Chandra A, Crow MK, Wormser GP, Alaedini A. Increased IFNα activity and differential antibody response in patients with a history of Lyme disease and persistent cognitive deficits. J Neuroimmunol. 2013 Feb 15;255(1-2):85-91. doi: 10.1016/j.jneuroim.2012.10.011. Epub 2012 Nov 8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557545/

^[7] Fallon BA, Keilp JG, Corbera KM, Petkova E, Britton CB, Dwyer E, Slavov I, Cheng J, Dobkin J, Nelson DR, Sackeim HA. A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy. Neurology. 2008 Mar 25;70(13):992-1003. Epub 2007 Oct 10. https://www.ncbi.nlm.nih.gov/pubmed/17928580

^[8] Logigian EL, Kaplan RF, Steere AC. Successful treatment of Lyme encephalopathy with intravenous ceftriaxone. J Infect Dis. 1999 Aug;180(2):377-83. https://jid.oxfordjournals.org/content/180/2/377.full

^[9] Balducci C, Mancini S, Minniti S, La Vitola P, Zotti M, Sancini G, Mauri M, Cagnotto A, Colombo L, Fiordaliso F, Grigoli E, Salmona M, Snellman A, Haaparanta-Solin M, Forloni G, Masserini M, Re F. Multifunctional liposomes reduce brain β-amyloid burden and ameliorate memory impairment in Alzheimer’s disease mouse models. J Neurosci. 2014 Oct 15;34(42):14022-31. doi: 10.1523/JNEUROSCI.0284-14.2014. https://www.ncbi.nlm.nih.gov/pubmed/25319699

^[10] Zhang XD, Xu DZ, Li JH, Wang T, Ge FH, Yang L. [Study on the immunocompetence of polysaccharide extracted from root of Salvia miltiorrhiza]. [Article in Chinese] Zhong Yao Cai. 2012 Jun;35(6):949-52. https://www.ncbi.nlm.nih.gov/pubmed/23236833

^[11] Błach-Olszewska Z, Jatczak B, Rak A, Lorenc M, Gulanowski B, Drobna A, Lamer-Zarawska E. Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones. J Interferon Cytokine Res. 2008 Sep;28(9):571-81. doi: 10.1089/jir.2008.0125. https://www.ncbi.nlm.nih.gov/pubmed/18771341

^[12] Reis SR, Valente LM, Sampaio AL, Siani AC, Gandini M, Azeredo EL, D’Avila LA, Mazzei JL, Henriques Md, Kubelka CF. Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2. Int Immunopharmacol. 2008 Mar;8(3):468-76. doi: 10.1016/j.intimp.2007.11.010. Epub 2007 Dec 26. https://www.ncbi.nlm.nih.gov/pubmed/18279801

^[13] Wang SQ, Li XJ, Zhou S, Sun DX, Wang H, Cheng PF, Ma XR, Liu L, Liu JX, Wang FF, Liang YF, Wu JM. Intervention effects of ganoderma lucidum spores on epileptiform discharge hippocampal neurons and expression of neurotrophin-4 and N-cadherin. PLoS One. 2013 Apr 24;8(4):e61687. doi: 10.1371/journal.pone.0061687. Print 2013. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634853/

^[14] Yao R, Zhang L, Li X, Li L. Effects of Epimedium flavonoids on proliferation and differentiation of neural stem cells in vitro. Neurol Res. 2010 Sep;32(7):736-42. doi: 10.1179/174313209X459183. Epub 2009 Aug 21. https://www.ncbi.nlm.nih.gov/pubmed/19703337

^[15] Kan QC, Lv P, Zhang XJ, Xu YM, Zhang GX, Zhu L. Matrine protects neuro-axon from CNS inflammation-induced injury. Exp Mol Pathol. 2015 Jan 7;98(1):124-130. doi: 10.1016/j.yexmp.2015.01.001. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/25576296

^[16] Soumyanath A, Zhong YP, Gold SA, Yu X, Koop DR, Bourdette D, Gold BG. Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro. J Pharm Pharmacol. 2005 Sep;57(9):1221-9. https://www.ncbi.nlm.nih.gov/pubmed/16105244

^[17] Chen DL, Zhang P, Lin L, Zhang HM, Deng SD, Wu ZQ, Ou S, Liu SH, Wang JY. Protective effects of bajijiasu in a rat model of Aβ₂₅₋₃₅-induced neurotoxicity. J Ethnopharmacol. 2014 May 28;154(1):206-17. doi: 10.1016/j.jep.2014.04.004. Epub 2014 Apr 14. https://www.ncbi.nlm.nih.gov/pubmed/24742752

^[18] Mu Q, Liu P, Hu X, Gao H, Zheng X, Huang H. Neuroprotective effects of Buyang Huanwu decoction on cerebral ischemia-induced neuronal damage. Neural Regen Res. 2014 Sep 1;9(17):1621-7. doi: 10.4103/1673-5374.141791. https://www.ncbi.nlm.nih.gov/pubmed/25368650

^[19] McMakin C. Frequency Specific Microcurrent in Pain Management. Edinburgh: Churchill Livingstone/Elsevier; 2011.

^[20] Courtney SM, Petit L, Haxby JV, Ungerleider LG. The role of prefrontal cortex in working memory: examining the contents of consciousness. Philos Trans R Soc Lond B Biol Sci. 1998 Nov 29;353(1377):1819-28. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1692423/

^[21] The Brain From the Top. https://thebrain.mcgill.ca/flash/d/d_10/d_10_cr/d_10_cr_lan/d_10_cr_lan.html

^[22] The Brain From Top to Bottom. https://thebrain.mcgill.ca/flash/i/i_07/i_07_cr/i_07_cr_tra/i_07_cr_tra.html

^[23] Neuroanatomy of memory. https://en.wikipedia.org/wiki/Neuroanatomy_of_memory

^[24] Schockert T. [Observations on cupping. High toxin concentration in blood from cupping]. MMW Fortschr Med. 2009 Jun 4;151(23):20. https://www.ncbi.nlm.nih.gov/pubmed/19591347

^[25] Liu CZ, Lei B, Zheng JF. [Randomized control study on the treatment of 26 cases of acne conglobata with encircling acupuncture combined with venesection and cupping]. [Article in Chinese] Zhen Ci Yan Jiu. 2008 Dec;33(6):406-8. https://www.ncbi.nlm.nih.gov/pubmed/19288903

Image courtesy of tracy from north brookfield,Massachusetts, usa. https://commons.wikimedia.org/wiki/File:Icicles_roof.jpg

For people diagnosed with Lyme disease that have chronic headaches, memory problems, and meningitis
by Greg Lee

Have you ever driven along a foggy road? On a drive through the mountains, I was enveloped by a thick fog. I had to slow down to 10 miles per hour because I could only see a few feet in front of me. My anxiety would increase if I saw something in the road. With my knuckles tightly grasping the wheel, my mind was hyper-focused on not hitting another car or a tree. How is driving through the fog similar to inflammation in the brain from Lyme disease?

Similar to fog along the road, inflammation from Lyme disease can slow down the brain
Lyme disease produces toxins and lipoproteins which trigger the immune system to produce many different kinds of inflammation. In the cerebrospinal fluid of Lyme disease patients, multiple inflammatory compounds have been detected: Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-12 (IL-12), Interleukin-18 (IL-18) and interferon-gamma (INF-γ) and the chemokine ligands CXCL12 and CXCL13¹. In another lab study, primary microglia cells, which are macrophages found in the brain and spinal cord, co-cultured with B. burgdorferi released inflammatory compounds IL-6, IL-8, chemokine (C-C motif) ligand-2 (CCL2), chemokine (C-C motif) ligand-3 (CCL3), chemokine (C-C motif) ligand-4 (CCL4), and chemokine (C-C motif) ligand-5 (CCL5)². Increased levels of an excitotoxin called quinolinic acid have been detected especially in Lyme patients with central nervous system inflammation³. Lyme patients with brain inflammation can have a variety of symptoms.

Lyme inflammation can aggravate symptoms of pain, swelling, poor concentration, and mood swings
Elevated inflammatory compounds have been associated with physical, mental, and emotional symptoms in patients. Some of these people report symptoms of brain fog⁴, concentration difficulties, memory recall problems, forgetfulness⁵, confusion, being spaced out, feeling ADD (attention deficit disorder), unable to process information, easily overwhelmed, and easily distractable. Physical symptoms have been described as pressure pushing out from the inside of the head, meningitis, chronic headaches⁶, dizziness⁷, vision problems⁸, stiffness, and a thick feeling in the head. Other people have described feeling depressed, suicidal, hopeless⁹, a lack of motivation, anxious¹⁰, and a lack of joy. Some medications help with reducing symptoms associated with Lyme inflammation.

Medications like Celebrex and Low Dose Naltrexone (LDN) can help relieve symptoms
LDN has been shown to reduce inflammatory symptoms, depression, and cognitive issues¹¹. Patients with Lyme disease have reported significant reductions in pain levels and inflammatory symptoms from LDN and Celebrex. Minocycline and doxycycline also reduce inflammatory cytokines tumor necrosis factor-alpha (TNFα) , IL-6, and IL-8¹². Unfortunately, some patients do not respond to LDN or Celebrex. And other patients may experience photosensitive skin reactions¹³ or digestion problems with extended antibiotic use¹⁴.

Are there natural treatments and remedies that can help to reduce inflammatory symptoms in the brain with minimal side effects?

Fortunately, there are five methods that can help to alleviate symptoms of Lyme disease inflammation in the central nervous system
These five methods include treatments and remedies that help patients to quickly relieve and eliminate the symptoms of inflammation in the nervous system. These methods have been effective in patients that have not improved with anti-inflammatory medications. These treatments and remedies draw out inflammation and toxins directly or have inhibited inflammatory cytokines in lab and animal studies.

Reduce CNS Inflammation Method #1: Cupping and bloodletting
Cupping combined with bloodletting has been practiced for thousands of years in Asia and the Middle East. Lyme patients with CNS inflammation have multiple suction cups placed on the head and neck to draw out toxins from the nervous system. Next, the cups are removed and needles are inserted to make very small holes to draw out the toxins. The needles are removed and the cups are placed back on. In each cup, a small quantity of fluid is drawn out of the body. In cupping studies, the extracted blood has been found to be high in toxins¹⁵ and inflammatory compounds¹⁶. Lyme disease patients that become more inflamed with antibiotics report greater mental clarity, reduced swelling and head pain, and increased emotional ease immediately after receiving cupping and bloodletting. Liposomal herbs also help with reducing inflammatory symptoms in the central nervous system.

Reduce CNS Inflammation Method #2: Liposomal herbs and supplements
A liposome is a microscopic particle that is surrounded with a fat also called a lipid. Liposomal remedies are more effective at penetrating inside the brain¹⁷ and the nervous system¹⁸ than their non-liposomal equivalents. When anti-inflammatory herbs and supplements are delivered via liposomes, patients with inflammatory symptoms experience greater relief of head pressure, sleep disturbances, and less painful emotions. These liposomal mixtures contain compounds that are formulated for reducing cytokines and chemokines that have been found in Lyme patients with inflammation and CNS symptoms and detected in lab studies.

Inflammatory cytokine / chemokine: anti-inflammatory herbs and supplements
CCL2: Bupleurum, Chinese name: Chai Hu¹⁹, Salvia miltiorrhiza Chinese name: Dan Shen²⁰, and Huperzine A²¹.
CCL3: Radix Sophorae, Chinese name: Ku Shen²² and Scrophularia, Chinese name: Xuan Shen²³.
CCL4: Scrophularia, Chinese name: Xuan Shen²⁴.
CCL5: Lemongrass, Chinese name: Xiang Mao Cao²⁵ and Nelumbo nucifera, lotus seed, Chinese name: Lian Zi²⁶.
CXCL12: Nigella sativa or black cumin seed, Chinese name: Hei Zhong Cao Zi²⁷ and Astragalus membranaceus, Chinese name: Huang Qi²⁸.
CXCL13: none found at the time of publication.

IL-6: Pueraria, Chinese name: Ge Gen²⁹, Gotu Kola, Chinese name: Ji Xue Cao³⁰, Andrographis paniculata, Chinese name: Chuan Xin Lian³¹, Isatidis root, Chinese name: Ban Lan Gen³², Polygonum cuspidatum, Japanese knotweed,
Chinese name: Hu Zhang³³, and Scutellaria, Chinese name: Huang Qin³⁴.
IL-8: Turmeric, Chinese name: Jiang Huang³⁵, Tree peony, Paeonia Suffruticosa, Chinese name: Mu Dan Pi³⁶, Scutellaria baicalensis, Chinese name: Huang Qin³⁷, Schisandra chinensis, Chinese name: Wu Wei Zi³⁸, Ginger, Chinese name: Gan Jiang³⁹, and Crataegus fruit, Chinese name: Shan Zha⁴⁰.
IL-12: Peony, Chinese name: Bai Shao⁴¹, Scutellaria baicalensis, Chinese name: Huang Qin⁴², Salvia root, Chinese name: Dan Shen⁴³, and Stephania tetrandra, Chinese name: Fang Ji⁴⁴.
IL-18: Emblica officinalis fruit, Ayurvedic name: Amalaki, Chinese name: Yu Gan Zi⁴⁵, Cordyceps, Chinese name: Dong Chong Xia Cao⁴⁶, Crataegus fruit, Chinese name: Shan Zha⁴⁷, Nigella sativa, Chinese name: Hei Zhong Cao Zi⁴⁸, Turmeric, Chinese name: Jiang Huang⁴⁹, Pulsatilla, Chinese name: Bai Tou Weng⁵⁰, and Salvia miltiorrhiza, Chinese name: Dan Shen⁵¹.
IFN-γ: Stephania tetrandra root, Chinese name: Fang Ji⁵², Acanthopanax senticosus, Chinese name: Ci Wu Jia⁵³, Taraxacum officinale, Chinese dandelion, Chinese name: Pu Gong Ying⁵⁴, and Peony, Chinese name: Bai
Shao⁵⁵.
Quinolinic acid: Sida cordifolia, Chinese name: Ke Dong, Ayurvedic name: Bala⁵⁶. Essential oils have also helped to clear inflammation in the nervous system.

Reduce CNS Inflammation Method #3: Sublingual essential oils
Lyme disease patients with CNS inflammation are given a customized formula of essential oils to take under their tongue (sublingual) and also in liposomal form to reduce inflammation in the nervous system. Anti-inflammatory essentail oils may include: lemongrass⁵⁷, clove⁵⁸, Nigella sativa or black cumin seed⁵⁹, ginger⁶⁰, turmeric⁶¹, and thyme⁶². Patients report better sleep, reduced head pressure, less post nasal drip, and greater mental clarity. Not only essential oils, but also Frequency Specific Microcurrent can be used to reduce inflammation.

Reduce CNS inflammation Method #4: Frequency Specific Microcurrent
Frequency Specific Microcurrent uses millionth of an ampere electrical currents to reduce toxicity and inflammation. Frequencies for decreasing inflammation, detoxifying, and promoting healing are combined with frequencies to target inflamed areas of the brain and nervous system. These anti-inflammatory frequencies can be directed into areas of the brain like the forebrain, midbrain, cerebellum, pineal, pituitary, basal ganglia, cingulate, meninges, prefrontal cortex, or the temporal lobe⁶³. Acupuncture and moxabustion can also help to target CNS inflammation.

Reduce CNS inflammation Method #5: Acupuncture and moxabustion
In human and animal studies, acupuncture⁶⁴ and herb partition moxabustion have been effective at reducing inflammatory compounds⁶⁵. Herb partition moxabustion places on a patient’s skin powdered anti-inflammatory herbs: cones of artemisia argyii (ai ye) over a combination of aconite cortex, Chinese name: Fu Zi or Cao Wu or Chuan Wu, Safflower, Chinese name: Hong Hua, and Salvia root, Chinese name: Dan Shen. The herbs are ignited to release their medicinal properties to reduce inflammation. Many treatments and remedies can help to address neurological inflammation symptoms.

Multiple remedies and treatments can help to reduce symptoms of neurological inflammation from Lyme disease
Similar to driving out of the fog, the proper combination of cupping and bloodletting, liposomal anti-inflammatory remedies, essential oils, Frequency Specific Microcurrent, acupuncture and moxabustion helps your brain to overcome the symptoms of neurological inflammation from Lyme disease. Since some of these remedies and treatments require specialized training, work with a Lyme literate Chinese medicine practitioner to develop a proper, safe, and effective strategy for your condition.

– Greg

P.S. Do you have experiences where treatments or remedies helped to relieve central nervous system inflammation from Lyme disease? Tell us about it.

>> Next step: Come to our evening lecture: Getting Rid of Lyme Disease in Frederick, Maryland on Monday January 5th at 6pm to learn more about treatments, essential oils, herbs, and homeopathic remedies for pain and inflammation from Lyme disease, Bartonella, toxoplasmosis, drug resistant arthritis, managing weight issues caused by toxins, reducing brain overwhelm, Epstein-Barr virus, adenovirus, brucellosis, Babesia, mold, parasites, abnormal fatigue, and pain.  https://goodbyelyme.com/events/get_rid_lyme

1. Bransfield RC. The psychoimmunology of lyme/tick-borne diseases and its association with neuropsychiatric symptoms. Open Neurol J. 2012;6:88-93. doi: 10.2174/1874205X01206010088. Epub 2012 Oct 5. https://www.ncbi.nlm.nih.gov/pubmed/23091569
2. Myers TA, Kaushal D, Philipp MT. Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells. PLoS Pathog. 2009 Nov;5(11):e1000659. doi:10.1371/journal.ppat.1000659. Epub 2009 Nov 13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771360/
3. Halperin JJ, Heyes MP. Neuroactive kynurenines in Lyme borreliosis. Neurology. 1992 Jan;42(1):43-50. https://www.ncbi.nlm.nih.gov/pubmed/1531156
4. Raffa RB. A proposed mechanism for chemotherapy-related cognitive impairment (‘chemofog’). J Clin Pharm Ther. 2011 Jun;36(3):257-9. doi: 10.1111/j.1365-2710.2010.01188.x. Epub 2010 Aug 24. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249621/
5. Abu Faddan NH, Shehata GA, Abd Elhafeez HA, Mohamed AO, Hassan HS, Abd El Sameea F. Cognitive function and endogenous cytokine levels in children with chronic hepatitis C. J Viral Hepat. 2014 Dec 15. doi: 10.1111/jvh.12373. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/25496114
6. Borde JP, Meier S, Fingerle V, Klier C, Hübner J, Kern WV. CXCL13 may improve diagnosis in early neuroborreliosis with atypical laboratory findings. BMC Infect Dis. 2012 Dec 10;12:344. doi: 10.1186/1471-2334-12-344. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528660/
7. Wensky AK, Furtado GC, Marcondes MC, Chen S, Manfra D, Lira SA, Zagzag D, Lafaille JJ. IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis. J Immunol. 2005 Feb 1;174(3):1416-23. https://www.ncbi.nlm.nih.gov/pubmed/15661899
8. Owen LA, Hartnett ME. Soluble mediators of diabetic macular edema: the diagnostic role of aqueous VEGF and cytokine levels in diabetic macular edema. Curr Diab Rep. 2013 Aug;13(4):476-80. doi: 10.1007/s11892-013-0382-z. https://www.ncbi.nlm.nih.gov/pubmed/23649946
9. Smith DF. Quest for biomarkers of treatment-resistant depression: shifting the paradigm toward risk. Front Psychiatry. 2013 Jun 18;4:57. doi: 10.3389/fpsyt.2013.00057. eCollection 2013.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684787/
10. R. K., D. M. A., C. N., S. N. W., C. D. Oxidative imbalance and anxiety disorders. Curr Neuropharmacol. 2014 Mar;12(2):193-204. doi: 10.2174/1570159X11666131120223530. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964749/
11. Brown N, Panksepp J. Low-dose naltrexone for disease prevention and quality of life. Med Hypotheses. 2009 Mar;72(3):333-7. doi: 10.1016/j.mehy.2008.06.048. Epub 2008 Nov 28. https://www.ncbi.nlm.nih.gov/pubmed/19041189
12. Bernardino AL, Kaushal D, Philipp MT. The antibiotics doxycycline and minocycline inhibit the inflammatory responses to the Lyme disease spirochete Borrelia burgdorferi. J Infect Dis. 2009 May 1;199(9):1379-88. doi: 10.1086/597807. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697124/
13. Drucker AM, Rosen CF. Drug-induced photosensitivity: culprit drugs, management and prevention. Drug Saf. 2011 Oct 1;34(10):821-37. doi: 10.2165/11592780-000000000-00000. https://www.ncbi.nlm.nih.gov/pubmed/21879777
14. Knecht H, Neulinger SC, Heinsen FA, Knecht C, Schilhabel A, Schmitz RA, Zimmermann A, dos Santos VM, Ferrer M, Rosenstiel PC, Schreiber S, Friedrichs AK, Ott SJ. Effects of β-lactam antibiotics and fluoroquinolones on human gut microbiota in relation to Clostridium difficile associated diarrhea. PLoS One. 2014 Feb 28;9(2):e89417. doi: 10.1371/journal.pone.0089417. eCollection 2014. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938479/
15. Schockert T. [Observations on cupping. High toxin concentration in blood from cupping]. MMW Fortschr Med. 2009 Jun 4;151(23):20. https://www.ncbi.nlm.nih.gov/pubmed/19591347
16. Liu CZ, Lei B, Zheng JF. [Randomized control study on the treatment of 26 cases of acne conglobata with encircling acupuncture combined with venesection and cupping]. [Article in Chinese] Zhen Ci Yan Jiu. 2008 Dec;33(6):406-8. https://www.ncbi.nlm.nih.gov/pubmed/19288903
17. Ohara M, Ohyama Y. Delivery and application of dietary polyphenols to target organs, tissues and intracellular organelles. Curr Drug Metab. 2014 Jan;15(1):37 47. https://www.ncbi.nlm.nih.gov/pubmed/24328691
18. Alhariri M, Azghani A, Omri A. Liposomal antibiotics for the treatment of infectious diseases. Expert Opin Drug Deliv. 2013 Nov;10(11):1515-32. doi: 10.1517/17425247.2013.822860. Epub 2013 Jul 26. https://www.ncbi.nlm.nih.gov/pubmed/23886421
19. Liu A, Tanaka N, Sun L, Guo B, Kim JH, Krausz KW, Fang Z, Jiang C, Yang J, Gonzalez FJ. Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. Chem Biol Interact. 2014 Sep 27;223C:80-86. doi: 10.1016/j.cbi.2014.09.012. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/25265579
20. Liu C, Li J, Wang L, Wu F, Huang L, Xu Y, Ye J, Xiao B, Meng F, Chen S, Yang M. Analysis of tanshinone IIA induced cellular apoptosis in leukemia cells by genome-wide expression profiling. BMC Complement Altern Med. 2012 Jan 16;12:5. doi: 10.1186/1472-6882-12-5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398275/
21. Tian GX, Zhu XQ, Chen Y, Wu GC, Wang J. Huperzine A inhibits CCL2 production in experimental autoimmune encephalomyelitis mice and in cultured astrocyte. Int J Immunopathol Pharmacol. 2013 Jul-Sep;26(3):757-64. https://www.ncbi.nlm.nih.gov/pubmed/24067473
22. Kan QC, Zhu L, Liu N, Zhang GX. Matrine suppresses expression of adhesion molecules and chemokines as a mechanism underlying its therapeutic effect in CNS autoimmunity. Immunol Res. 2013 May;56(1):189-96. doi: 10.1007/s12026-013-8393-z. https://www.ncbi.nlm.nih.gov/pubmed/23549837
23. Motojima H, Villareal MO, Iijima R, Han J, Isoda H. Acteoside inhibits type Ι allergy through the down-regulation of Ca/NFAT and JNK MAPK signaling pathways in basophilic cells. J Nat Med. 2013 Oct;67(4):790-8. doi: 10.1007/s11418-013-0753-4. Epub 2013 Mar 15. https://www.ncbi.nlm.nih.gov/pubmed/23494816
24. Motojima H, Villareal MO, Iijima R, Han J, Isoda H. Acteoside inhibits type Ι allergy through the down-regulation of Ca/NFAT and JNK MAPK signaling pathways in basophilic cells. J Nat Med. 2013 Oct;67(4):790-8. doi: 10.1007/s11418-013-0753-4. Epub 2013 Mar 15. https://www.ncbi.nlm.nih.gov/pubmed/23494816
25. Francisco V, Costa G, Figueirinha A, Marques C, Pereira P, Miguel Neves B, Celeste Lopes M, García-Rodríguez C, Teresa Cruz M, Teresa Batista M. Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-κB pathway inhibition: contribution of chlorogenic acid. J Ethnopharmacol. 2013 Jun 21;148(1):126-34. doi: 10.1016/j.jep.2013.03.077. Epub 2013 Apr 10. https://www.ncbi.nlm.nih.gov/pubmed/23583902
26. Li G, Xu H, Zhu S, Xu W, Qin S, Liu S, Tu G, Peng H, Qiu S, Yu S, Zhu Q, Fan B, Zheng C, Li G, Liang S. Effects of neferine on CCL5 and CCR5 expression in SCG of type 2 diabetic rats. Brain Res Bull. 2013 Jan;90:79-87. doi: 10.1016/j.brainresbull.2012.10.002. Epub 2012 Oct 9. https://www.ncbi.nlm.nih.gov/pubmed/23063706
27. Badr G, Mohany M, Abu-Tarboush F. Thymoquinone decreases F-actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl-XL expression. Lipids Health Dis. 2011 Dec 16;10:236. doi: 10.1186/1476-511X-10-236. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339355/
28. Li Q, Bao JM, Li XL, Zhang T, Shen XH. Inhibiting effect of Astragalus polysaccharides on the functions of CD4+CD25 highTreg cells in the tumor microenvironment of human hepatocellular carcinoma. Chin Med J (Engl). 2012 Mar;125(5):786-93. https://www.ncbi.nlm.nih.gov/pubmed/22490576
29. Liu X, Mei Z, Qian J, Zeng Y, Wang M. Puerarin partly counteracts the inflammatory response after cerebral ischemia/reperfusion via activating the cholinergic anti-inflammatory pathway. Neural Regen Res. 2013 Dec 5;8(34):3203-15. doi: 10.3969/j.issn.1673-5374.2013.34.004. https://www.ncbi.nlm.nih.gov/pubmed/25206641
30. Giribabu N, Srinivasarao N, Swapna Rekha S, Muniandy S, Salleh N. Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats. Evid Based Complement Alternat Med. 2014;2014:592062. doi: 10.1155/2014/592062. Epub 2014 Aug 5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139016/
31. Kou W, Sun R, Wei P, Yao HB, Zhang C, Tang XY, Hong SL. Andrographolide suppresses IL-6/Stat3 signaling in peripheral blood mononuclear cells from patients with chronic rhinosinusitis with nasal polyps. Inflammation. 2014 Oct;37(5):1738-43. doi: 10.1007/s10753-014-9902-5. https://www.ncbi.nlm.nih.gov/pubmed/24803294
32. Wang CX, Cao HY, Cheng M, Xu HR, Wang MZ, Xu LL, Yu HY, Li Q. [The influence of representative herbs of clearing and detoxifying drugs effect on inflammatory cytokines expression of mice lung homogenate infected by influenza virus FM1]. [Article in Chinese] Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2012 Dec;26(6):415-8. https://www.ncbi.nlm.nih.gov/pubmed/23627017
33. Wang CX, Cao HY, Cheng M, Xu HR, Wang MZ, Xu LL, Yu HY, Li Q. [The influence of representative herbs of clearing and detoxifying drugs effect on inflammatory cytokines expression of mice lung homogenate infected by influenza virus FM1]. [Article in Chinese] Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2012 Dec;26(6):415-8. https://www.ncbi.nlm.nih.gov/pubmed/23627017
34. Wang CX, Cao HY, Cheng M, Xu HR, Wang MZ, Xu LL, Yu HY, Li Q. [The influence of representative herbs of clearing and detoxifying drugs effect on inflammatory cytokines expression of mice lung homogenate infected by influenza virus FM1]. [Article in Chinese] Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2012 Dec;26(6):415-8. https://www.ncbi.nlm.nih.gov/pubmed/23627017
35. Saelee C, Thongrakard V, Tencomnao T. Effects of Thai medicinal herb extracts with antipsoriatic activity on the expression on NF-κB signaling biomarkers in HaCaT keratinocytes. Molecules. 2011 May 10;16(5):3908-32. doi: 10.3390/molecules16053908. https://www.ncbi.nlm.nih.gov/pubmed/21555979
36. Oh GS, Pae HO, Choi BM, Jeong S, Oh H, Oh CS, Rho YD, Kim DH, Shin MK, Chung HT. Inhibitory effects of the root cortex of Paeonia suffruticosa on interleukin-8 and macrophage chemoattractant protein-1 secretions in U937 cells. J Ethnopharmacol. 2003 Jan;84(1):85-9. https://www.ncbi.nlm.nih.gov/pubmed/12499080
37. Luo W, Wang CY, Jin L. Baicalin downregulates Porphyromonas gingivalis lipopolysaccharideupregulated IL-6 and IL-8 expression in human oral keratinocytes by negative regulation of TLR signaling. PLoS One. 2012;7(12):e51008. doi: 10.1371/journal.pone.0051008. Epub 2012 Dec 11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519831/
38. Bae H, Kim R, Kim Y, Lee E, Jin Kim H, Pyo Jang Y, Jung SK, Kim J. Effects of Schisandra chinensis Baillon (Schizandraceae) on lipopolysaccharide induced lung inflammation in mice. J Ethnopharmacol. 2012 Jun 26;142(1):41-7. doi: 10.1016/j.jep.2012.04.009. Epub 2012 Apr 21. https://www.ncbi.nlm.nih.gov/pubmed/22543173
39. Podlogar JA, Verspohl EJ. Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells. Phytother Res. 2012 Mar;26(3):333-6. doi:10.1002/ptr.3558. Epub 2011 Jun 23. https://www.ncbi.nlm.nih.gov/pubmed/21698672
40. Zhang J, Liang R, Wang L, Yan R, Hou R, Gao S, Yang B. Effects of an aqueous extract of Crataegus pinnatifida Bge. var. major N.E.Br. fruit on experimental atherosclerosis in rats. J Ethnopharmacol. 2013 Jul 9;148(2):563-9. doi: 10.1016/j.jep.2013.04.053. Epub 2013 May 16. https://www.ncbi.nlm.nih.gov/pubmed/23685195
41. Wang YN, Zhang Y, Wang Y, Zhu DX, Xu LQ, Fang H, Wu W. The beneficial effect of total glucosides of paeony on psoriatic arthritis links to circulating Tregs and Th1 cell function. Phytother Res. 2014 Mar;28(3):372-81. doi: 10.1002/ptr.5005. Epub 2013 Apr 23. https://www.ncbi.nlm.nih.gov/pubmed/23610010
42. Kim ME, Kim HK, Park HY, Kim DH, Chung HY, Lee JS. Baicalin from Scutellaria baicalensis impairs Th1 polarization through inhibition of dendritic cell maturation. J Pharmacol Sci. 2013;121(2):148-56. https://www.ncbi.nlm.nih.gov/pubmed/23419270
43. Sun A, Liu H, Wang S, Shi D, Xu L, Cheng Y, Wang K, Chen K, Zou Y, Ge J. Salvianolic acid B suppresses maturation of human monocyte-derived dendritic cells by activating PPARγ. Br J Pharmacol. 2011 Dec;164(8):2042-53. doi: 10.1111/j.1476-5381.2011.01518.x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246666/
44. Feng D, Mei Y, Wang Y, Zhang B, Wang C, Xu L. Tetrandrine protects mice from concanavalin A-induced hepatitis through inhibiting NF-kappaB activation. Immunol Lett. 2008 Dec 22;121(2):127-33. doi: 10.1016/j.imlet.2008.10.001. Epub 2008 Nov 4. https://www.ncbi.nlm.nih.gov/pubmed/18992279
45. Aruna R, Geetha A, Suguna P, Suganya V. Rutin rich Emblica officinalis Geart. fruit extract ameliorates inflammation in the pancreas of rats subjected to alcohol and cerulein administration. J Complement Integr Med. 2014 Feb 7;11(1):9-18. doi: 10.1515/jcim-2013-0023. https://www.ncbi.nlm.nih.gov/pubmed/24516008
46. Zhao K, Li Y, Zhang H. Role of dongchongxiacao (Cordyceps) in prevention of contrastinduced  nephropathy in patients with stable angina pectoris. J Tradit Chin Med. 2013 Jun;33(3):283-6. https://www.ncbi.nlm.nih.gov/pubmed/24024319
47. Zhang J, Liang R, Wang L, Yan R, Hou R, Gao S, Yang B. Effects of an aqueous extract of Crataegus pinnatifida Bge. var. major N.E.Br. fruit on experimental atherosclerosis in rats. J Ethnopharmacol. 2013 Jul 9;148(2):563-9. doi: 10.1016/j.jep.2013.04.053. Epub 2013 May 16. https://www.ncbi.nlm.nih.gov/pubmed/23685195
48. Ahmad I, Muneer KM, Tamimi IA, Chang ME, Ata MO, Yusuf N. Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome. Toxicol Appl Pharmacol. 2013 Jul 1;270(1):70-6. doi: 10.1016/j.taap.2013.03.027. Epub 2013 Apr 10. https://www.ncbi.nlm.nih.gov/pubmed/23583630
49. Somanawat K, Thong-Ngam D, Klaikeaw N. Curcumin attenuated paracetamol overdose induced hepatitis. World J Gastroenterol. 2013 Mar 28;19(12):1962-7. doi:
10.3748/wjg.v19.i12.1962. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613112/
50. Wang ZL, Sun PP, Li TX, Li SX. [Pulsatilla decoction treat inflammatory bowel disease by activating NLRP3]. [Article in Chinese] Zhong Yao Cai. 2012 Aug;35(8):1280-
6.https://www.ncbi.nlm.nih.gov/pubmed/23320362
51. Zhou ZH, Weng Q, Zhou JH, Zhou J. Extracts of Salvia miltiorrhiza Bunge on the cytokines of rat endometriosis models. Afr J Tradit Complement Altern Med. 2012 Apr 2;9(3):303-14. eCollection 2012. https://www.ncbi.nlm.nih.gov/pubmed/23983360
52. Feng D, Mei Y, Wang Y, Zhang B, Wang C, Xu L. Tetrandrine protects mice from concanavalin A-induced hepatitis through inhibiting NF-kappaB activation. Immunol Lett. 2008 Dec 22;121(2):127-33. doi: 10.1016/j.imlet.2008.10.001. Epub 2008 Nov 4. https://www.ncbi.nlm.nih.gov/pubmed/18992279
53. Lin QY, Jin LJ, Cao ZH, Xu YP. Inhibition of inducible nitric oxide synthase by Acanthopanax senticosus extract in RAW264.7 macrophages. J Ethnopharmacol. 2008 Jul 23;118(2):231-6. doi: 10.1016/j.jep.2008.04.003. Epub 2008 Apr 11. https://www.ncbi.nlm.nih.gov/pubmed/18486372
54. Zhang X, Xiong H, Li H, Cheng Y. Protective effect of taraxasterol against LPS-induced endotoxic shock by modulating inflammatory responses in mice. Immunopharmacol
Immunotoxicol. 2014 Feb;36(1):11-6. doi: 10.3109/08923973.2013.861482. Epub 2013 Nov 29. https://www.ncbi.nlm.nih.gov/pubmed/24286370
55. Wang YN, Zhang Y, Wang Y, Zhu DX, Xu LQ, Fang H, Wu W. The beneficial effect of total glucosides of paeony on psoriatic arthritis links to circulating Tregs and Th1 cell function. Phytother Res. 2014 Mar;28(3):372-81. doi: 10.1002/ptr.5005. Epub 2013 Apr 23. https://www.ncbi.nlm.nih.gov/pubmed/23610010
56. Swathy SS, Panicker S, Nithya RS, Anuja MM, Rejitha S, Indira M. Antiperoxidative and antiinflammatory effect of Sida cordifolia Linn. on quinolinic acid induced neurotoxicity. Neurochem Res. 2010 Sep;35(9):1361-7. doi: 10.1007/s11064-010-0192-5. Epub 2010 May 25. https://www.ncbi.nlm.nih.gov/pubmed/20499166
57. Francisco V, Costa G, Figueirinha A, Marques C, Pereira P, Miguel Neves B, Celeste Lopes M, García-Rodríguez C, Teresa Cruz M, Teresa Batista M. Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-κB pathway inhibition: contribution of chlorogenic acid. J Ethnopharmacol. 2013 Jun 21;148(1):126-34. doi: 10.1016/j.jep.2013.03.077. Epub 2013 Apr 10. https://www.ncbi.nlm.nih.gov/pubmed/23583902
58. Grespan R, Paludo M, Lemos Hde P, Barbosa CP, Bersani-Amado CA, Dalalio MM, Cuman RK. Anti-arthritic effect of eugenol on collagen-induced arthritis experimental model. Biol Pharm Bull. 2012;35(10):1818-20. https://www.ncbi.nlm.nih.gov/pubmed/23037170
59. Badr G, Mohany M, Abu-Tarboush F. Thymoquinone decreases F-actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl-XL expression. Lipids Health Dis. 2011 Dec 16;10:236. doi: 10.1186/1476-511X-10-236. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339355/
60. Podlogar JA, Verspohl EJ. Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells. Phytother Res. 2012 Mar;26(3):333-6. doi: 10.1002/ptr.3558. Epub 2011 Jun 23. https://www.ncbi.nlm.nih.gov/pubmed/21698672
61. Song Y, Ge W, Cai H, Zhang H. Curcumin protects mice from coxsackievirus B3-induced myocarditis by inhibiting the phosphatidylinositol 3 kinase/Akt/nuclear factor-κB pathway. J Cardiovasc Pharmacol Ther. 2013 Nov;18(6):560-9. doi: 10.1177/1074248413503044. Epub 2013 Sep 19. https://www.ncbi.nlm.nih.gov/pubmed/24057864
62. A. Ocaña and G. Reglero, “Effects of Thyme Extract Oils (from Thymus vulgaris, Thymus zygis, and Thymus hyemalis) on Cytokine Production and Gene Expression of oxLDL-Stimulated THP-1-Macrophages,” Journal of Obesity, vol. 2012, Article ID 104706, 11 pages, 2012. doi:10.1155/2012/104706 https://www.hindawi.com/journals/jobe/2012/104706/
63. Frequency Specific Microcurrent Advanced Summary Protocols. https://www.frequencyspecific.com/faq.php#protocol
64. Qi YC, Xiao XJ, Duan RS, Yue YH, Zhang XL, Li JT, Li YZ. Effect of acupuncture on inflammatory cytokines expression of spastic cerebral palsy rats. Asian Pac J Trop Med. 2014 Jun;7(6):492-5. doi: 10.1016/S1995-7645(14)60081-X. https://www.ncbi.nlm.nih.gov/pubmed/25066401
65. Bao CH, Zhao JM, Liu HR, Lu Y, Zhu YF, Shi Y, Weng ZJ, Feng H, Guan X, Li J, Chen WF, Wu LY, Jin XM, Dou CZ, Wu HG. Randomized controlled trial: moxibustion and acupuncture for the treatment of Crohn’s disease. World J Gastroenterol. 2014 Aug 21;20(31):11000-11. doi: 10.3748/wjg.v20.i31.11000. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138481/

Image courtesy David Wright of Wikimedia Commons https://commons.wikimedia.org/wiki/File:Downhill_through_the_Tulgy_Wood_to_Bonby_-_geograph.org.uk_-_1066231.jpg

SPLD  Lyme egroup signup

Name:

Email:

We respect your email privacy

Powered by AWeber Email Marketing Software

//

For people with Lyme disease who have sore, swollen tendons and joints after taking cipro
by Greg Lee

Have you ever regretted leaving something outside in the rain? I took a wooden table outside to hold some snacks for guests. Towards evening, we took everything back inside except the table. That night, a passing shower soaked the table. Unfortunately, the table top was made out of pressed wood and warped into a roller coaster shape from the rain.

How is a warped table top similar to joint inflammation after taking ciprofloxacin?

Similar to rain that has warped a table, ciprofloxacin can warp joints out of shape
Ciprofloxacin, also known as cipro, is an antibiotic used to treat many infections including Lyme disease and co-infections. This drug has been effective against a broad range of pathogens including many gram negative bacteria. It belongs to a class of antibiotics called fluoroquinolones. Cipro has been used especially to treat infections in the respiratory, urinary, and digestion tracts. Unfortunately, cipro can produce painful conditions especially in joints, including tendon rupture^[1]. The high risk of tendon damage has also been acknowledged by the US Food and Drug Administration placing a “Black Box” warning on the drug. Patients at greater risk are over 60 years old, corticosteroid users, nursing infants, and kidney, lung, and heart transplant recipients^[2]. There are clears signs and symptoms associated with ciprofloxacin tendon damage.

Ciprofloxacin can produce redness and swelling around affected tendons and joints
After taking ciproflaxin for three days, Anton experienced redness, swelling, and severe pain in his left wrist. The redness and pain migrated to his left hip and left ankle. He was unable to use these joints due to severe pain. Other patients have reported similar symptoms that lasted for weeks after taking cipro. Cipro has been found to degrade type-I collagen found in tendons, joints, and skin by upregulating Matrix metallopeptidase 2 (MMP-2)^[3]. This antibiotic has been cited repeatedly as the cause of Achilles tendon ruptures. If a tendon has been ruptured, then a joint will become immovable.

Cipro has also been associated with gastrointestinal upset, neurological symptoms, headache, dizziness, insomnia, skin eruptions, vision damage, gait problems^[4], Clostridium dificile diarrhea^[5], and irreversible peripheral neuropathy, weakness, burning pain, tingling, or numbness^[6]. This antibiotic can deplete important compounds like magnesium^[7] and glutathione^[8] out of collagen. Higher doses have been found to lead to a greater severity of symptoms. Symptoms can occur hours to several months after taking the medication. Once tendon or joint symptoms occur, patients are recommended to discontinue taking the medication. What are the recommendations for reducing tendon inflammation and damage after taking cipro?

Rest and physical therapy are recommended for treating cipro pain and inflammation
Rest and physical therapy are the main recommendations for reducing cipro damage in symptomatic tendons and joints. Unfortunately, this approach relies solely upon the body’s ability to detoxify the cipro and repair the damage.

If tendon pain or rupture can occur months after taking cipro, what else can help patients to reduce pain and inflammation and protect against tendon rupture?

Here are five strategies for reducing pain, inflammation and repairing collagen damage in people who have taken cipro
There are five strategies that can help to reduce the symptoms of pain and inflammation in patients that have been taking ciprofloxacin. These strategies focus on reducing inflammation through treatment and natural remedies. Some of these strategies are also for promoting the repair of damaged collagen.

Strategy #1: Cupping and bloodletting to reduce inflammation in affected joints
Anton discontinued use of cipro when his first symptoms appeared. Despite stopping quickly, his symptoms continued to migrate along his left side. Fortunately, he received a treatment called wet cupping which applied suction cups to the symptomatic joints. During this procedure, the cups were removed and needles were used to make small holes where the cup had been. Next, the needles were removed and the cups were re-applied to pull out inflammation^[9]. Within a few minutes, the redness and swelling disappeared. At the end of the treatment, Anton reported a 90% reduction in pain and discomfort, and a much greater flexibility in his joint mobility. A treatment called Frequency Specific Microcurrent was also used to reduce inflammation and promote healing.

Strategy #2: Frequency Specific Microcurrent for reducing inflammation, inorganic chemicals, and promoting healing
Frequency Specific Microcurrent uses very low electrical signals of a millionth of an amp to reduce inflammation, detoxify inorganic chemicals, and promote healing in ligament, tendons, and joints^[10]. These frequencies can be directed into specific joints all over the body. Anton received multiple sessions of Frequency Specific Microcurrent aimed at clearing inflammation and repairing his damaged joints. Supplements can also help with reducing symptoms and promoting collagen healing.

Strategy #3: Supplements for reducing collagen damage
Anton added magnesium and vitamin E to his daily supplements. In one rat study, rats fed a diet supplemented with magnesium and vitamin E for ten days had a decreased amount of ciprofloxacin induced joint cartilage lesions^[11]. He also received customized liposomal remedies to protect against cipro damage.

Strategy #4: Liposomal nutrients for reducing inflammation
Anton was given a liposomal remedy of glutathione and ascorbic acid (vitamin C), which provided substantial protection against ciprofloxacin in one lab study^[12]. Glutathione is a compound produced in the body, that helps to reduce inflammation and toxicity^[13]. In addition to supplements, herbs can also help to reduce inflammation in patients damaged by cipro.

Strategy #5: Liposomal herbs for reducing serum levels of cipro, lowering inflammation, and restoring collagen
Anton was also given a liposomal herbal combination to stop the spreading of his symptoms, reducing inflammation, and to promote healing of damaged collagen. His herbs included Chinese dandelion, sanguisorbia, red root, sophora root, scutellaria, angelica root, astragalus root, and rehmannia root.

In one rat study, Chinese dandelion, Chinese name: Pu Gong Ying lowered the maximum plasma concentration of cipro by 73%^[14], and sanguisorbia, Chinese name: Di Yu lowered the maximum plasma concentration by 94%^[15]. In a rat study, a compound called Tanshinone IIA found in red root, Salvia miltiorrhiza, Chinese name: Dan Shen reduced MMP-2 levels^[16]. Matrine which is a compound found in sophora root, Chinese name: Ku Shen also reduced MMP-2 in another rat study^[17]. Wogonin is found in scutellaria baicalensis, Chinese name: Huang Qin and was found in a lab study to reduce MMP-2^[18]. A compound called SBD.4 found in angelica root increased Type-I collagen in a human dermal fibroblast study^[19]. In another lab study, astragalus root, Chinese name: Huang Qi combined with rehmannia root, Chinese name: Sheng Di Huang upregulated the expression of Type I and Type III collagen^[20]. A combination of treatment and remedies can be effective at overcoming the damage caused by ciprofloxacin.

Using a combination of remedies and treatments can help you to reduce inflammation and promote healing in cipro damaged joints
Just like sanding smooth the warped areas and refinishing the table top, the proper combination of treatments, anti-inflammatory, and collagen healing remedies can help to counteract the damage caused by cipro. Cupping and bloodletting, Frequency Specific Microcurrent, supplements, and liposomal remedies helped Anton to clear inflammation, reduce stiffness and pain, and rapidly promote healing of damaged collagen in his tendons and joints. In a few treatments, the redness, swelling, and pain was gone from his joints. Since some of these remedies and treatments require specialized training, work with a Lyme literate Chinese medicine practitioner to develop a proper, safe, and effective strategy for your condition.

– Greg

P.S. Do you have experiences where treatments or remedies helped to relieve damage from cipro treatment? Tell us about it.

>> Next step: Come to our evening lecture: Getting Rid of Lyme Disease in Frederick, Maryland on Monday October 6th at 6pm to learn more about treatments, essential oils, herbs, and homeopathic remedies for pain and inflammation from cipro, Bartonella, toxoplasmosis, Lyme disease, drug resistant arthritis, managing weight issues caused by toxins, reducing brain overwhelm, Epstein-Barr virus, adenovirus, brucellosis, Babesia, mold, parasites, abnormal fatigue, and pain.  https://goodbyelyme.com/events/get_rid_lyme

^[1] Menon A, Pettinari L, Martinelli C, Colombo G, Portinaro N, Dalle-Donne I, d’Agostino MC, Gagliano N. New insights in extracellular matrix remodeling and collagen turnover related pathways in cultured human tenocytes after ciprofloxacin administration. Muscles Ligaments Tendons J. 2013 Aug 11;3(3):122-31. eCollection 2013. https://www.ncbi.nlm.nih.gov/pubmed/24367771

^[2] Kawtharani F, Masrouha KZ, Afeiche N. Bilateral Achilles Tendon Ruptures Associated with Ciprofloxacin Use in the Setting of Minimal Change Disease: Case Report and Review of the Literature. J Foot Ankle Surg. 2014 Sep 1. pii: S1067-2516(14)00323-8. doi: 10.1053/j.jfas.2014.07.005. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/25189336

^[3] Tsai WC, Hsu CC, Chen CP, Chang HN, Wong AM, Lin MS, Pang JH. Ciprofloxacin up-regulates tendon cells to express matrix metalloproteinase-2 with degradation of type I collagen. J Orthop Res. 2011 Jan;29(1):67-73. doi: 10.1002/jor.21196. https://www.ncbi.nlm.nih.gov/pubmed/20602464

^[4] G. K. Kim, The Risk of Fluoroquinolone-induced Tendinopathy and Tendon Rupture: What Does The Clinician Need To Know? J Clin Aesthet Dermatol. Apr 2010; 3(4): 49–54. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921747/

^[5] Owens RC Jr, Donskey CJ, Gaynes RP, Loo VG, Muto CA. Antimicrobial-associated risk factors for Clostridium difficile infection. Clin Infect Dis. 2008 Jan 15;46 Suppl 1:S19-31. doi: 10.1086/521859. https://cid.oxfordjournals.org/content/46/Supplement_1/S19.full

^[6] FDA Drug Safety Communication: FDA requires label changes to warn of risk for possibly permanent nerve damage from antibacterial fluoroquinolone drugs taken by mouth or by injection. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/019537s082,020780s040lbl.pdf

^[7] K. Pfister, D. Mazur, J. Vormann, and R. Stahlmann, Diminished Ciprofloxacin-Induced Chondrotoxicity by Supplementation with Magnesium and Vitamin E in Immature Rats. Antimicrob Agents Chemother. Mar 2007; 51(3): 1022–1027. Published online Jan 8, 2007. doi:  10.1128/AAC.01175-06. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1803142/

^[8] V. Talla and P.R. Veerareddy. Oxidative Stress Induced by Fluoroquinolones on Treatment for Complicated Urinary Tract Infections in Indian Patients. J Young Pharm. 2011 Oct-Dec; 3(4): 304–309. doi:  10.4103/0975-1483.90242 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249743/

^[9] Zhang CQ, Liang TJ, Zhang W. Effects of drug cupping therapy on immune function in chronic asthmatic bronchitis patients during protracted period. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Nov; 26(11) pp. 984-7. https://www.ncbi.nlm.nih.gov/pubmed/17186726

^[10] Dong P, Zhang Y, Gu J, Wu W, Li M, Yang J, Zhang L, Lu J, Mu J, Chen L, Li S, Wang J, Liu Y.. Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin. J Ethnopharmacol. 2011 Oct 11;137(3):1373-80. doi: 10.1016/j.jep.2011.08.005. Epub 2011 Aug 6. https://www.ncbi.nlm.nih.gov/pubmed/21855619

^[11] K. Pfister, D. Mazur, J. Vormann, and R. Stahlmann, Diminished Ciprofloxacin-Induced Chondrotoxicity by Supplementation with Magnesium and Vitamin E in Immature Rats. Antimicrob Agents Chemother. Mar 2007; 51(3): 1022–1027. Published online Jan 8, 2007. doi:  10.1128/AAC.01175-06. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1803142/

^[12] M. Goswami, S. H. Mangoli, and N. Jawali. Involvement of Reactive Oxygen Species in the Action of Ciprofloxacin against Escherichia coli. Antimicrob Agents Chemother. Mar 2006; 50(3): 949–954. doi:  10.1128/AAC.50.3.949-954.2006. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426460/

^[13] Rahman I. Inflammation and the regulation of glutathione level in lung epithelial cells. Antioxid Redox Signal. 1999 Winter;1(4):425-47. https://www.ncbi.nlm.nih.gov/pubmed/11233143

^[14] Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 179. https://www.amazon.com/Chinese-Medical-Herbology-Pharmacology-John/dp/0974063509

^[15] Chen, John K., and Tina T. Chen. 2004. Chinese Medical Herbology and Pharmacology. City of Industry CA: Art of Medicine Press, Inc., p. 569. https://www.amazon.com/Chinese-Medical-Herbology-Pharmacology-John/dp/0974063509

^[16] Jiang P, Li C, Xiang Z, Jiao B. Tanshinone IIA reduces the risk of Alzheimer’s disease by inhibiting iNOS, MMP‑2 and NF‑κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer’s disease. Mol Med Rep. 2014 Aug;10(2):689-94. doi: 10.3892/mmr.2014.2254. Epub 2014 May 20. https://www.ncbi.nlm.nih.gov/pubmed/24859152

^[17] Zhang S, Kan QC, Xu Y, Zhang GX, Zhu L. Inhibitory effect of matrine on blood-brain barrier disruption for the treatment of experimental autoimmune encephalomyelitis. Mediators Inflamm. 2013;2013:736085. doi: 10.1155/2013/736085. Epub 2013 Sep 8. https://www.ncbi.nlm.nih.gov/pubmed/24194630

^[18] Dong P, Zhang Y, Gu J, Wu W, Li M, Yang J, Zhang L, Lu J, Mu J, Chen L, Li S, Wang J, Liu Y. Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin. J Ethnopharmacol. 2011 Oct 11;137(3):1373-80. doi: 10.1016/j.jep.2011.08.005. Epub 2011 Aug 6. https://www.ncbi.nlm.nih.gov/pubmed/21855619

^[19] Zhao H, Deneau J, Che GO, Li S, Vagnini F, Azadi P, Sonon R, Ramjit R, Lee SM, Bojanowski K. Angelica sinensis isolate SBD.4: composition, gene expression profiling, mechanism of action and effect on wounds, in rats and humans. Eur J Dermatol. 2012 Jan-Feb;22(1):58-67. doi: 10.1684/ejd.2011.1599. https://www.ncbi.nlm.nih.gov/pubmed/22146555

^[20] Zhang Q, Fong CC, Yu WK, Chen Y, Wei F, Koon CM, Lau KM, Leung PC, Lau CB, Fung KP, Yang M. Herbal formula Astragali Radix and Rehmanniae Radix exerted wound healing effect on human skin fibroblast cell line Hs27 via the activation of transformation growth factor (TGF-β) pathway and promoting extracellular matrix (ECM) deposition. Phytomedicine. 2012 Dec 15;20(1):9-16. doi: 10.1016/j.phymed.2012.09.006. Epub 2012 Oct 17. https://www.ncbi.nlm.nih.gov/pubmed/23083814

Image courtesy of David40226543 on Wikimedia Commons