How These Four Herbs Help to Stop Bartonella Rage and Obsessive Compulsive Disorder (OCD)

For people who have been diagnosed with Bartonella that have severe anger and obsessive compulsive behaviors
by Greg Lee

A few months ago I got a surprise call from my credit card provider who asked if I had made a recent $900 purchase from a clothing store in New York. I told them that I didn’t. They also asked about other charges made in shops and restaurants in the same area. Somehow my credit card number was stolen and being used. Several charges had accumulated in a short period of time before the card was canceled.

How is a thief that buys stuff on your credit card just like anger and obsessive behaviors caused by a Bartonella infection?

Just like fraudulent credit card charges that are made without your knowledge, Bartonella can quietly infect organs and tissues throughout the body

Bartonella is a Gram-negative bacterial infection that can be transmitted by insect bites, including fleas, lice, sand flies[1], flea feces,[2] mites[3], and possibly by ticks[4], spiders[5], or bed bugs[6]. This infection may also be transmitted by infected animal bites[7], scratches[8], or possibly by blood transfusion[9] or organ transplant[10].  There are over thirty species of Bartonella, and seventeen of these can infect humans[11]. This bacteria has been found to infect the liver, lymph nodes, skin[12], teeth[13], bones, heart, spleen, eyes, kidney, and brain[14]. This infection manipulates the circulatory system to spread through the body.

Bartonella stimulates the production of vascular endothelial growth factor (VEGF) to invade the body

VEGF is produced in the body to stimulate the production of new blood vessels[15]. In one study that looked at two species of Bartonella henselae, genotype I, aka Houston-1, and II, aka Marseille strain, genotype I was more virulent in human cells due to it’s ability to increase VEGF production and it’s receptor VEGFR-2 in human microvascular endothelial cells[16]. As new blood vessels grow due to VEGF production, Bartonella is then able to infect and spread through the endothelial cell lining of these new vessels[17]. Antibiotics are often the first course of treatment.

Antibiotics are highly effective in killing Bartonella in the lab but not as effective in people

In multiple lab studies, Bartonella was successfully eliminated using these antibiotics: amoxycillin and ceftriaxone, aminoglycosides, doxycycline, rifampicin, erythromycin doxycycline, and ciprofloxacin[18]. However, treatment failures and relapses have been reported with rifampin, ciprofloxacin, gentamicin, co-trimoxazole, and azithromycin[19]. One reason for these failures may be due to resistant strains of Bartonella to antibiotics: quinolones[20], rifampin[21], macrolides[22], fluoroquinolones[23], and gentamicin[24]. Another reason for antibiotic treatment failure may be due to this bacterias ability to produce or to hide within a protective slime called a biofilm. In one study, B. quintana was discovered in a exopolysaccharide (EPS)-like matrix, i.e. bioflm, in lice feces[25]. Biofilms are believed to increase drug resistance up to a thousand times[26]. This infection can produce a wide variety of physical and emotional symptoms.

Bartonella can produce many symptoms including anger, rage and obsessive compulsive disorder (OCD) behaviors
A Bartonella infection can produce symptoms of anemia[27], frequent headaches, visual and auditory hallucinations, anxiety, vision loss, paralysis, facial palsy, chronic insomnia, seizures, dizziness, cognitive dysfunction, and memory loss[28]. It has been found to mimic symptoms of multiple sclerosis (MS)[29], stroke[30], vasculitis[31], breast tumors, pancreatic, biliary or pharyngeal cancer[32], and rheumatic disease[33]. One Lyme literate specialist reports anger, rage and obsessive compulsive behavior in her Bartonella patients[34]. Obsessive behavior may be associated with a reaction in a specific area of the brain.

A specific region of the brain called the basal ganglia is associated with obsessive compulsive behavior

Obsessive compulsive behaviors are a signature symptom in children diagnosed with Pediatric Autoimmune Disorders Associated with Strep (PANDAS). In children with PANDAs, an infection by group A beta-hemolytic streptococcus (GABHS), toxins, or inflammation stimulates an autoimmune reaction in the basal ganglia area of the brain[35]. This reaction produces obsessive compulsive disorder (OCD) behaviors[36]. In one study, 19% of Bartonella patients showed lesions on brain MRIs in the cerebral white matter, basal ganglia, thalamus, and gray matter[37]. If Bartonella can produce abnormal MRI lesions in the basal ganglia, then it may be capable of producing OCD behaviors similar to a PANDAS infection.

What else can help you to stop a resistant Bartonella infection that produces angry outbursts, rage, or obsessive compulsive behaviors?

In Chinese medicine, anger, rage, and compulsive behaviors are associated with an imbalance in the liver

In Chinese medicine, when the liver becomes too hot or too dry due to excess toxins, a person may exhibit symptoms of sudden anger or rage[38]. A Chinese medicine diagnosis of liver stagnation, also known as congestion, along with a spleen deficiency is associated with OCD behaviors[39]. Obsessive compulsive behaviors have also been identified in people with toxic parasitic infections called Gu Syndrome in Chinese medicine texts[40]. Some patients with obsessive behaviors report a need to have their environment in a precise order by putting things in a specific place, extreme anxiety over unexpected surprises that disrupt daily rituals, or thoughts like, “Did I lock the door?” that they worry about over and over again. Fortunately, there are four herbs which may help to reduce obsessive behaviors, inhibit VEGF production, and lower rage by cooling and moistening the liver.

Here are four herbs for stopping Bartonella from spreading and causing painful emotions

Limiting VEGF production may help to stop Bartonella from spreading. Harmonizing the liver is a Chinese medicine strategy for lowering rage and obsessive compulsive behaviors. Formulating remedies into microparticles called liposomes increases their penetration into endothelial cells[41] where Bartonella hides out, the liver[42], and the basal ganglia[43] Liposomal remedies have also been effective at reducing the production of VEGF[44] and its receptor VEGFR2[45], which may help to limit the virulence of Bartonella. These herbs have been used for centuries in traditional medicine formulas for treating angry outbursts, rage, and obsessive compulsive disorder (OCD) behavior.

Stopping Bartonella Rage and OCD Herb #1: Angelica sinensis

Angelica sinensis, Chinese name Dang Gui, has antimicrobial, neuro-protective, anticancer, anticoagulant, and liver-protective properties. In Chinese medicine, angelica is used to strengthen and replenish the blood and it’s used to treat anemia, pale complexion, dry hair, dizziness, blurred vision, fatigue and weakness, palpitations and pain[46]. It is a primary ingredient in multiple Chinese herbal formulas for reducing angry outbursts or rage due to a liver imbalance[47] called liver yin deficiency or liver fire blazing.

In a lab study, angelica was effective at reducing VEGF[48]. In another study, angelica was effective at increasing cognitive abilities and brain plasticity of rats when under chronic stress[49]. Angelica also has demonstrated anti-endotoxin properties in multiple animal studies[50]. This herb has demonstrated an inhibitory effect on Salmonella typhi, E. coli, Corynebacterium diptheriae, Vibrio cholerae, alpha-hemolytic streptococcus, and beta-hemolytic streptococcus[51]. Another herb that is often used with angelica is peony.

Stopping Bartonella Rage and OCD Herb #2: White peony root

White peony root, Chinese name Bai Shao, has anti-inflammatory, antibiotic, CNS calming, and digestion healing properties. In Chinese medicine, white peony is used to nourish the blood, treat anemia, regulate menstrual disorders, relieve pain, reduce night sweats, nourish, cool and soften the liver[52]. A compound found in white peony called total glucosides was effective in reducing the abnormal proliferation of VEGF in a rat study[53]. Paeoniflorin, another component of white peony, demonstrated liver protective[54] and anti-endotoxin[55] properties in multiple animal studies. Albiflorin, another compound in white peony, demonstrated similar anti-inflammatory properties compared to paeoniflorin[56].

This herb has shown to have an inhibitory effect against Bacillus dysenteriae, E. Coli, Salmonella typhi, Pseudonomas aeruginosa, Staphyloccus aureus, beta-hemolytic streptococcus, and Diplococcus pneumoniae[57]. Peony is often paired with angelica in herbal formulas for treating liver imbalances, including those that are marked by irritation, rage, and angry outbursts[58]. Bupleurum is another herb used in traditional Chinese medicine for supporting the liver.

Stopping Bartonella Rage and OCD Herb #3: Bupleurum

Bupleurum, Chinese name Chai Hu, has pathogen expelling, anti-malarial, liver harmonizing, and yang lifting properties. In Chinese medicine, bupleurum is used to treat infections with symptoms of fever, chills, fullness in the chest, bitter taste in the mouth, dry throat, poor appetite, nausea, vertigo, and irritability. This herb is often used to treat malaria, emotional distress, eye disorders, breast swelling and pain, irregular menstruation, jaundice, migraines, and prolapsed organs[59]. In Chinese herbal formulas, this herb is used to release anger and frustration that is inexpressible[60].

This herb has an inhibitory effect on B-hemolytic streptococcus, Vibrio cholerae, Mycobacterium tuberculosis, leptospirosis (a spirochete infection), influenza viruses, and hepatitus viruses Buplerum is cautioned in patients with excessive dryness and heat symptoms. There may an increased risk of acute pneumonitis when this herb is used with interferon[61]. Polysaccharides found in this herb have anti-toxin properties[62]. Bupleurum reduced depression in one human study by increasing Nerve Growth Factor (NGF) and Brain Derived Neurotrophic Factor (BDNF)[63]. In a rat study, an herbal formula with bupleurum was effective at reducing inflammatory cytokines causing jaundice and liver hepatitis[64]. Bupleurum is a component with angelica and white peony in a famous formula called “Rambling Powder” to treat liver stagnation[65]. Withania somnifera is another herb for calming the emotions.

Stopping Bartonella Rage and OCD Herb #4: Withania somnifera

Withania somnifera, also called ashwagandha, has a very revered place in ayurvedic medicine. It’s properties are tonifying, replenishing, longevity enhancing, adaptogenic, stress reducing, anti-tumor, neuroregenerative, anti-arthritic, aphrodisiac, narcotic, diuretic, anthelmintic, astringent, thermogenic, and stimulant[66].

Withania somnifera has been used to treat the following conditions: arthritis, inflammatory conditions, anxiety, insomnia, respiratory disorders, asthma, and bronchitis. It is also used to treat disorders of the nervous, immune, and the reproductive system. It is especially used to treat nervousness, depression, digestion problems, and low libido[67]. This herb has also been used to treat gastric ulcers, uterine fibroids, dementia, memory problems, Parkinson’s, Huntington’s, Alzheimer’s disease, mitochondrial energy depletion, rheumatoid, and osteoarthritis[68].

In one mouse study, Withania somnifera was effective at inhibiting obsessive compulsive behavior[69]. In a rat study, Withania somnifera demonstrated liver protective and anti-inflammatory effects against gentamicin liver damage[70]. This herb was also effective in multiple studies against Staphylococcus aureus, Methicilin Resistance Staphylococcus aureus (MRSA)[71], Enterococcus spp.[72], Escherichia coli, Salmonella typhi, Citrobacter freundii, Pseudomonas aeruginosa, Klebsiella pneumoniae[73], Aeromonas hydrophila[74], Plasmodium berghei[75], Linoleic and oleic acids from Withania somnifera were effective at inhibiting streptococcus mutans biofilms[76]. Withaferin A and withanone are compounds found in this herb that show inhibitiatory potential against leshmania protozoa[77]. Withaferin A also inhibited the production of H. pylori induced inflammatory compound IL-1beta[78], MMP-9[79] produced by metastatic cancer cells, and VEGF produced by brain cancer cells[80] in lab experiments. Using a combination of these herbs can help to fight the uncomfortable emotions triggered by a Bartonella infection.

These four herbs can help to reduce painful emotions of rage and obsessive compulsive behaviors from a Bartonella infection

People with Lyme disease that have uncontrolled anger, rage and obsessive behaviors may have a stealthy Bartonella infection affecting their liver and nervous system. Similar to canceling a credit card with fraudulent charges, these herbs may help to stop the spread of Bartonella through inhibiting VEGF. By harmonizing and decongesting the liver, these herbs may help to reduce angry outbursts and obsessive compulsive behaviors. Using liposomal anti-Bartonella herbs may be more effective in stopping Bartonella inside the liver, the basal ganglia in the brain, and in endothelial cells. Since some of these herbs have cautions on their use, work with a Lyme literate natural remedy practitioner to develop a proper, safe, and effective strategy for your condition.

– Greg

Next step: Come to the Getting Rid of Lyme Disease evening lecture on Monday August 1st at 6pm in Frederick, Maryland to learn more about essential oils, herbs, and treatments for healing from Lyme disease and co-infection symptoms.

https://goodbyelyme.com/events/get_rid_lyme

Also learn about effective remedies and treatments for relieving persistent symptoms of Lyme and co-infections including: cold laser, Frequency Specific Microcurrent, cupping, LED therapy, moxabustion, acupuncture, liposomal herbs, essential oils, bee venom, and more!

P.S. Do you have experiences where remedies or treatments helped you to stop angry outbursts, rage, or obsessive compulsive behaviors due to a Bartonella infection? Tell us about it.


[1]“Transmission | Bartonella | CDC.” Accessed July 22, 2016. https://www.cdc.gov/bartonella/transmission/.

[2]Chomel, B. B., and R. W. Kasten. “Bartonellosis, an Increasingly Recognized Zoonosis.” Journal of Applied Microbiology 109, no. 3 (September 2010): 743–50. doi:10.1111/j.1365-2672.2010.04679.x. https://www.ncbi.nlm.nih.gov/pubmed/20148999

[3]Bradley, Julie M., Patricia E. Mascarelli, Chelsea L. Trull, Ricardo G. Maggi, and Edward B. Breitschwerdt. “Bartonella Henselae Infections in an Owner and Two Papillon Dogs Exposed to Tropical Rat Mites (Ornithonyssus Bacoti).” Vector Borne and Zoonotic Diseases (Larchmont, N.Y.) 14, no. 10 (October 2014): 703–9. doi:10.1089/vbz.2013.1492. https://www.ncbi.nlm.nih.gov/pubmed/25325313

[4]Billeter, S. A., M. G. Levy, B. B. Chomel, and E. B. Breitschwerdt. “Vector Transmission of Bartonella Species with Emphasis on the Potential for Tick Transmission.” Medical and Veterinary Entomology 22, no. 1 (March 2008): 1–15. doi:10.1111/j.1365-2915.2008.00713.x. https://www.ncbi.nlm.nih.gov/pubmed/18380649

[5]Mascarelli, Patricia E., Ricardo G. Maggi, Sarah Hopkins, B. Robert Mozayeni, Chelsea L. Trull, Julie M. Bradley, Barbara C. Hegarty, and Edward B. Breitschwerdt. “Bartonella Henselae Infection in a Family Experiencing Neurological and Neurocognitive Abnormalities after Woodlouse Hunter Spider Bites.” Parasites & Vectors 6 (2013): 98. doi:10.1186/1756-3305-6-98. https://www.ncbi.nlm.nih.gov/pubmed/23587343

[6]Leulmi, Hamza, Idir Bitam, Jean Michel Berenger, Hubert Lepidi, Jean Marc Rolain, Lionel Almeras, Didier Raoult, and Philippe Parola. “Competence of Cimex Lectularius Bed Bugs for the Transmission of Bartonella Quintana, the Agent of Trench Fever.” PLoS Neglected Tropical Diseases 9, no. 5 (May 2015): e0003789. doi:10.1371/journal.pntd.0003789. https://www.ncbi.nlm.nih.gov/pubmed/26000974

[7]Mosbacher, Mark, Sean P. Elliott, Ziad Shehab, Jacob L. Pinnas, John H. Klotz, and Stephen A. Klotz. “Cat Scratch Disease and Arthropod Vectors: More to It than a Scratch?” Journal of the American Board of Family Medicine: JABFM 23, no. 5 (October 2010): 685–86. doi:10.3122/jabfm.2010.05.100025. https://www.ncbi.nlm.nih.gov/pubmed/20823366

[8]Pennisi, Maria Grazia, Fulvio Marsilio, Katrin Hartmann, Albert Lloret, Diane Addie, Sándor Belák, Corine Boucraut-Baralon, et al. “Bartonella Species Infection in Cats: ABCD Guidelines on Prevention and Management.” Journal of Feline Medicine and Surgery 15, no. 7 (July 2013): 563–69. doi:10.1177/1098612X13489214. https://www.ncbi.nlm.nih.gov/pubmed/23813816

[9]Diniz, Pedro Paulo Vissotto de Paiva, Paulo Eduardo Neves Ferreira Velho, Luiza Helena Urso Pitassi, Marina Rovani Drummond, Bruno Grosselli Lania, Maria Lourdes Barjas-Castro, Stanley Sowy, Edward B. Breitschwerdt, and Diana Gerardi Scorpio. “Risk Factors for Bartonella Species Infection in Blood Donors from Southeast Brazil.” PLoS Neglected Tropical Diseases 10, no. 3 (March 2016): e0004509. doi:10.1371/journal.pntd.0004509. https://www.ncbi.nlm.nih.gov/pubmed/26999057

[10]Scolfaro, C., F. Mignone, F. Gennari, A. Alfarano, A. Veltri, R. Romagnoli, and M. Salizzoni. “Possible Donor-Recipient Bartonellosis Transmission in a Pediatric Liver Transplant.” Transplant Infectious Disease: An Official Journal of the Transplantation Society 10, no. 6 (December 2008): 431–33. doi:10.1111/j.1399-3062.2008.00326.x. https://www.ncbi.nlm.nih.gov/pubmed/18651873

[11]Buhner, Stephen Harrod. Healing Lyme Disease Coinfections: Complementary and Holistic Treatments for Bartonella and Mycoplasma. Inner Traditions / Bear & Co, 2013.

[12]Bonatti, Hugo, Julio Mendez, Ivan Guerrero, Murli Krishna, Jaime Ananda-Michel, Joseph Yao, Jeffery L. Steers, Walter Hellinger, Rolland C. Dickson, and Salvador Alvarez. “Disseminated Bartonella Infection Following Liver Transplantation.” Transplant International: Official Journal of the European Society for Organ Transplantation 19, no. 8 (August 2006): 683–87. doi:10.1111/j.1432-2277.2006.00336.x.

https://www.ncbi.nlm.nih.gov/pubmed/16827686

[13]Drancourt, Michel, Lam Tran-Hung, Jean Courtin, Henry de Lumley, and Didier Raoult. “Bartonella Quintana in a 4000-Year-Old Human Tooth.” The Journal of Infectious Diseases 191, no. 4 (February 15, 2005): 607–11. doi:10.1086/427041. https://www.ncbi.nlm.nih.gov/pubmed/15655785

[14]Poudel, Atul, Judy Lew, William Slayton, and Vikas R. Dharnidharka. “Bartonella Henselae Infection Inducing Hemophagocytic Lymphohistiocytosis in a Kidney Transplant Recipient.” Pediatric Transplantation 18, no. 3 (May 2014): E83-87. https://www.ncbi.nlm.nih.gov/pubmed/24829973

[15]“Vascular Endothelial Growth Factor.” Wikipedia, the Free Encyclopedia, July 13, 2016. https://en.wikipedia.org/w/index.php?title=Vascular_endothelial_growth_factor&oldid=729597948.

[16]Berrich, Moez, Claudine Kieda, Catherine Grillon, Martine Monteil, Nathalie Lamerant, Julie Gavard, Henri Jean Boulouis, and Nadia Haddad. “Differential Effects of Bartonella Henselae on Human and Feline Macro- and Micro-Vascular Endothelial Cells.” PLOS ONE 6, no. 5 (May 27, 2011): e20204. doi:10.1371/journal.pone.0020204. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020204

[17]Harms, Alexander, and Christoph Dehio. “Intruders below the Radar: Molecular Pathogenesis of Bartonella Spp.” Clinical Microbiology Reviews 25, no. 1 (January 2012): 42–78. doi:10.1128/CMR.05009-11.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255967/

[18]Rolain, Jean-Marc, Max Maurin, and Didier Raoult. “Bactericidal Effect of Antibiotics on Bartonella and Brucella Spp.: Clinical Implications.” Journal of Antimicrobial Chemotherapy 46, no. 5 (November 1, 2000): 811–14. doi:10.1093/jac/46.5.811. https://jac.oxfordjournals.org/content/46/5/811.full

[19]Rolain, J. M., P. Brouqui, J. E. Koehler, C. Maguina, M. J. Dolan, and D. Raoult. “Recommendations for Treatment of Human Infections Caused by Bartonella Species.” Antimicrobial Agents and Chemotherapy 48, no. 6 (June 2004): 1921–33. doi:10.1128/AAC.48.6.1921-1933.2004. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC415619/

[20]del Valle, Luis J., Lidia Flores, Martha Vargas, Ruth García-de-la-Guarda, Ruth L. Quispe, Zoila B. Ibañez, Débora Alvarado, Pablo Ramírez, and Joaquim Ruiz. “Bartonella Bacilliformis, Endemic Pathogen of the Andean Region, Is Intrinsically Resistant to Quinolones.” International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases 14, no. 6 (June 2010): e506-510. doi:10.1016/j.ijid.2009.07.025. https://www.ncbi.nlm.nih.gov/pubmed/19969497

[21]“Molecular Characterisation of Resistance to Rifampin in Bartonella Quintana – Biswas – 2008 – Clinical Microbiology and Infection – Wiley Online Library.” Accessed July 26, 2016. https://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2008.02179.x/full. https://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2008.02179.x/full

[22]Biswas, Silpak, Didier Raoult, and Jean-Marc Rolain. “Molecular Characterization of Resistance to Macrolides in Bartonella Henselae.” Antimicrobial Agents and Chemotherapy 50, no. 9 (September 2006): 3192–93. doi:10.1128/AAC.00263-06. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1563522/

[23]Angelakis, Emmanouil, Didier Raoult, and Jean-Marc Rolain. “Molecular Characterization of Resistance to Fluoroquinolones in Bartonella Henselae and Bartonella Quintana.” Journal of Antimicrobial Chemotherapy, April 15, 2009, dkp133. doi:10.1093/jac/dkp133. https://jac.oxfordjournals.org/content/early/2009/04/15/jac.dkp133.full

[24]Biswas, S., D. Raoult, and J.-M. Rolain. “Molecular Mechanism of Gentamicin Resistance in Bartonella Henselae.” Clinical Microbiology and Infection 15 (December 1, 2009): 98–99. doi:10.1111/j.1469-0691.2008.02178.x. https://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2008.02178.x/pdf

[25]Chomel, Bruno B., Henri-Jean Boulouis, Edward B. Breitschwerdt, Rickie W. Kasten, Muriel Vayssier-Taussat, Richard J. Birtles, Jane E. Koehler, and Christoph Dehio. “Ecological Fitness and Strategies of Adaptation of Bartonella Species to Their Hosts and Vectors.” Veterinary Research 40, no. 2 (2009). doi:10.1051/vetres/2009011. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695021/

[26]Chopra, Lipsy, Gurdeep Singh, Kautilya Kumar Jena, and Debendra K. Sahoo. “Sonorensin: A New Bacteriocin with Potential of an Anti-Biofilm Agent and a Food Biopreservative.” Scientific Reports 5 (2015): 13412. doi:10.1038/srep13412. https://www.ncbi.nlm.nih.gov/pubmed/26292786

[27]Van Audenhove, A., G. Verhoef, W. E. Peetermans, M. Boogaerts, and P. Vandenberghe. “Autoimmune Haemolytic Anaemia Triggered by Bartonella Henselae Infection: A Case Report.” British Journal of Haematology 115, no. 4 (December 2001): 924–25. https://www.ncbi.nlm.nih.gov/pubmed/11843827

[28]Balakrishnan, Nandhakumar, Marna Ericson, Ricardo Maggi, and Edward B. Breitschwerdt. “Vasculitis, Cerebral Infarction and Persistent Bartonella Henselae Infection in a Child.” Parasites & Vectors 9, no. 1 (2016): 254. doi:10.1186/s13071-016-1547-9.  https://www.ncbi.nlm.nih.gov/pubmed/27161220

[29]Brinar, Vesna V., and Mario Habek. “Rare Infections Mimicking MS.” Clinical Neurology and Neurosurgery 112, no. 7 (September 2010): 625–28. doi:10.1016/j.clineuro.2010.04.011. https://www.ncbi.nlm.nih.gov/pubmed/20439131

[30]Marienfeld, Carla B., Daniel B. Dicapua, Gordon K. Sze, and Jonathan M. Goldstein. “Expressive Aphasia as a Presentation of Encephalitis with Bartonella Henselae Infection in an Immunocompetent Adult.” The Yale Journal of Biology and Medicine 83, no. 2 (June 2010): 67–71.  https://www.ncbi.nlm.nih.gov/pubmed/20589186

[31]Teoh, Laurence S G, Hamish H Hart, May Ching Soh, Jonathan P Christiansen, Hasan Bhally, Martin S Philips, and Dominic S Rai-Chaudhuri. “Bartonella Henselae Aortic Valve Endocarditis Mimicking Systemic Vasculitis.” BMJ Case Reports 2010 (October 21, 2010). doi:10.1136/bcr.04.2010.2945.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030181/

[32]Florin, Todd A., Theoklis E. Zaoutis, and Lisa B. Zaoutis. “Beyond Cat Scratch Disease: Widening Spectrum of Bartonella Henselae Infection.” Pediatrics 121, no. 5 (May 2008): e1413-1425. doi:10.1542/peds.2007-1897.  https://www.ncbi.nlm.nih.gov/pubmed/18443019

[33]Maggi, Ricardo G., B. Robert Mozayeni, Elizabeth L. Pultorak, Barbara C. Hegarty, Julie M. Bradley, Maria Correa, and Edward B. Breitschwerdt. “Bartonella Spp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease–endemic Region.” Emerging Infectious Diseases 18, no. 5 (May 2012). doi:10.3201/eid1805.111366.  https://wwwnc.cdc.gov/eid/article/18/5/11-1366_article

[34]Corson, A. The Diagnosis and Treatment of Tick-Borne Diseases. Lyme Disease in the Family Conference. Salisbury, MD July 9th, 2011.

[35]Marconi, Daniela, Lucilla Limpido, Iliana Bersani, Annalisa Giordano, and Giuseppe Bersani. “[PANDAS: a possible model for adult OCD pathogenesis].” Rivista Di Psichiatria 44, no. 5 (October 2009): 285–98. https://www.ncbi.nlm.nih.gov/pubmed/20066816

[36]Orefici, Graziella, Francesco Cardona, Carol J. Cox, and Madeleine W. Cunningham. “Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS).” In Streptococcus Pyogenes: Basic Biology to Clinical Manifestations, edited by Joseph J. Ferretti, Dennis L. Stevens, and Vincent A. Fischetti. Oklahoma City (OK): University of Oklahoma Health Sciences Center, 2016. https://www.ncbi.nlm.nih.gov/books/NBK333433/. https://www.ncbi.nlm.nih.gov/pubmed/26866234

[37]Florin, Todd A., Theoklis E. Zaoutis, and Lisa B. Zaoutis. “Beyond Cat Scratch Disease: Widening Spectrum of Bartonella Henselae Infection.” P. 1417.

[38]“The 5 Organs Network of Chinese Medicine – Liver.” Accessed July 26, 2016. https://www.itmonline.org/5organs/liver.htm.

[39]“Obsessive-Compulsive Disorder – Encyclopedia of Alternative Medicine – altMD.com Article.” Accessed July 28, 2016. https://www.altmd.com/Articles/Obsessive-Compulsive-Disorder–Encyclopedia-of-Alt.

[40]Administrator. “An Ancient Solution for Modern Diseases: ‘Gu Syndrome’ and Chronic Inflammatory Diseases with Autoimmune Complications (An Interview with Heiner Fruehauf).” ClassicalChineseMedicine.org, December 15, 2012. https://classicalchinesemedicine.org/gpa/ancient-solution-modern-diseases-gu-syndrome-chronic-inflammatory-diseases-autoimmune-complications/.

[41]Santos, Adriana O., Lígia C. Gomes da Silva, Luís M. Bimbo, Maria C. Pedroso de Lima, Sérgio Simões, and João N. Moreira. “Design of Peptide-Targeted Liposomes Containing Nucleic Acids.” Biochimica Et Biophysica Acta 1798, no. 3 (March 2010): 433–41. doi:10.1016/j.bbamem.2009.12.001. https://www.ncbi.nlm.nih.gov/pubmed/20004174

[42]Elmowafy, Mohammed, Tapani Viitala, Hany M. Ibrahim, Sherif K. Abu-Elyazid, Ahmed Samy, Alaa Kassem, and Marjo Yliperttula. “Silymarin Loaded Liposomes for Hepatic Targeting: In Vitro Evaluation and HepG2 Drug Uptake.” European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 50, no. 2 (October 9, 2013): 161–71. doi:10.1016/j.ejps.2013.06.012. https://www.ncbi.nlm.nih.gov/pubmed/23851081

[43]Mora, Margarita, Maria-Luisa Sagristá, Domenico Trombetta, Francesco P. Bonina, Anna De Pasquale, and Antonella Saija. “Design and Characterization of Liposomes Containing Long-Chain N-acylPEs for Brain Delivery: Penetration of Liposomes Incorporating GM1 into the Rat Brain.” Pharmaceutical Research 19, no. 10 (October 2002): 1430–38. https://www.ncbi.nlm.nih.gov/pubmed/12425459

[44]Leite, Elaine A., Cristina M. Souza, Alvaro D. Carvalho-Júnior, Luiz G. V. Coelho, Angela M. Q. Lana, Geovanni D. Cassali, and Mônica C. Oliveira. “Encapsulation of Cisplatin in Long-Circulating and pH-Sensitive Liposomes Improves Its Antitumor Effect and Reduces Acute Toxicity.” International Journal of Nanomedicine 7 (2012): 5259–69. doi:10.2147/IJN.S34652. https://www.ncbi.nlm.nih.gov/pubmed/23091378

[45]Wicki, Andreas, Christoph Rochlitz, Annette Orleth, Reto Ritschard, Imke Albrecht, Richard Herrmann, Gerhard Christofori, and Christoph Mamot. “Targeting Tumor-Associated Endothelial Cells: Anti-VEGFR2 Immunoliposomes Mediate Tumor Vessel Disruption and Inhibit Tumor Growth.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 18, no. 2 (January 15, 2012): 454–64. doi:10.1158/1078-0432.CCR-11-1102. https://www.ncbi.nlm.nih.gov/pubmed/22065082

[46]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. pp. 918-924.

[47]“The 5 Organs Network of Chinese Medicine – Liver.” Accessed July 26, 2016. https://www.itmonline.org/5organs/liver.htm.

[48]Lee, Wei-Hwa, Jong-Shiaw Jin, Wen-Chiuan Tsai, Yu-Ting Chen, Wen-Liang Chang, Chen-Wen Yao, Lia-Fa Sheu, and Ann Chen. “Biological Inhibitory Effects of the Chinese Herb Danggui on Brain Astrocytoma.” Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology 73, no. 3 (2006): 141–48. doi:10.1159/000095560. https://tmu.pure.elsevier.com/en/publications/biological-inhibitory-effects-of-the-chinese-herb-danggui-on-brai

[49]Deng, Min, Huimin Sun, Jun Shen, Yuanteng Fan, Lei Zhang, and Junjian Zhang. “Radix Angelica Sinensis Promotes Synaptic Plasticity During Cognitive Recovery in Chronically Stressed Rats.” Current Neurovascular Research 12, no. 3 (July 7, 2015): 232–39. doi:10.2174/1567202612666150603125710. https://m.eurekaselect.com/131933/article

[50]Wang, Haichao, Wei Li, Jianhua Li, Beatriz Rendon-Mitchell, Mahendar Ochani, Mala Ashok, Lihong Yang, et al. “The Aqueous Extract of a Popular Herbal Nutrient Supplement, Angelica Sinensis, Protects Mice against Lethal Endotoxemia and Sepsis.” The Journal of Nutrition 136, no. 2 (February 2006): 360–65. https://www.ncbi.nlm.nih.gov/pubmed/16424112

[51]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. p. 921.

[52]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. pp. 930-934.

[53]Zhu, L., W. Wei, Y.-Q. Zheng, and X.-Y. Jia. “Effects and Mechanisms of Total Glucosides of Paeony on Joint Damage in Rat Collagen-Induced Arthritis.” Inflammation Research: Official Journal of the European Histamine Research Society … [et Al.] 54, no. 5 (May 2005): 211–20. doi:10.1007/s00011-005-1345-x. https://www.ncbi.nlm.nih.gov/pubmed/15953993

[54]Kim, In Deok, and Bae Jin Ha. “The Effects of Paeoniflorin on LPS-Induced Liver Inflammatory Reactions.” Archives of Pharmacal Research 33, no. 6 (June 2010): 959–66. doi:10.1007/s12272-010-0620-8. https://www.ncbi.nlm.nih.gov/pubmed/20607502

[55]Liu, Ling, Xiang-jun Qiu, Su-na He, Hui Yang, Deng Wang, and Xue-mei Yang. “[Effect of paeoniflorin on oxidative stress and energy metabolism in mice with lipopolysaccharide (LPS)-induced brain injury].” Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica 40, no. 14 (July 2015): 2871–75. https://www.ncbi.nlm.nih.gov/pubmed/26666042

[56]Wang, Qiang-Song, Teng Gao, Yuan-Lu Cui, Li-Na Gao, and Heng-Li Jiang. “Comparative Studies of Paeoniflorin and Albiflorin from Paeonia Lactiflora on Anti-Inflammatory Activities.” Pharmaceutical Biology 52, no. 9 (September 2014): 1189–95. doi:10.3109/13880209.2014.880490. https://www.ncbi.nlm.nih.gov/pubmed/24646307

[57]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. p. 932.

[58]“The 5 Organs Network of Chinese Medicine – Liver.” Accessed July 26, 2016. https://www.itmonline.org/5organs/liver.htm.

[59]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. pp. 84-87.

[60]“Towards a Spirit at Peace – Chapter 8: Traditional Herb Formulas.” Accessed July 28, 2016. https://www.itmonline.org/shen/chap8.htm.

[61]Chen, John K., and Tina T. Chen. Chinese Medical Herbology & Pharmacology. Edited by Laraine Crampton. 1st edition. City of Industry, Calif: Art of Medicine Press, 2004. p. 85.

[62]Wu, Jian, Yun-Yi Zhang, Li Guo, Hong Li, and Dao-Feng Chen. “Bupleurum Polysaccharides Attenuates Lipopolysaccharide-Induced Inflammation via Modulating Toll-like Receptor 4 Signaling.” PloS One 8, no. 10 (2013): e78051. doi:10.1371/journal.pone.0078051. https://www.ncbi.nlm.nih.gov/pubmed/24167596

[63]Wang, Xia, Qing Feng, Yong Xiao, and Ping Li. “Radix Bupleuri Ameliorates Depression by Increasing Nerve Growth Factor and Brain-Derived Neurotrophic Factor.” International Journal of Clinical and Experimental Medicine 8, no. 6 (2015): 9205–17. https://www.ncbi.nlm.nih.gov/pubmed/26309578

[64]Lin, L., W. M. Cai, C. J. Qin, L. C. Miao, L. T. Yun, Y. Hua, and L. Weilin. “Intervention of TLR4 Signal Pathway Cytokines in Severe Liver Injury with Obstructive Jaundice in Rats.” International Journal of Sports Medicine 33, no. 7 (July 2012): 572–79. doi:10.1055/s-0031-1301318. Lin, L., W. M. Cai, C. J. Qin, L. C. Miao, L. T. Yun, Y. Hua, and L. Weilin. “Intervention of TLR4 Signal Pathway Cytokines in Severe Liver Injury with Obstructive Jaundice in Rats.” International Journal of Sports Medicine 33, no. 7 (July 2012): 572–79. doi:10.1055/s-0031-1301318. https://www.ncbi.nlm.nih.gov/pubmed/22562737

[65]Beau. “Psychospiritual Aspects of Herbal Medicine.” Accessed July 28, 2016. https://www.planetherbs.com/theory/psychospiritual-aspects-of-herbal-medicine.html.

[66]Singh, Narendra, Mohit Bhalla, Prashanti de Jager, and Marilena Gilca. “An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda.” African Journal of Traditional, Complementary, and Alternative Medicines 8, no. 5 Suppl (July 3, 2011): 208–13. doi:10.4314/ajtcam.v8i5S.9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252722/

[67]Beau. “Ashwagandha: Wonder Herb of India.” Accessed July 28, 2016. https://www.planetherbs.com/specific-herbs/ashwagandha-wonder-herb-of-india.html.

[68]Singh, Narendra, Mohit Bhalla, Prashanti de Jager, and Marilena Gilca. “An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda.” African Journal of Traditional, Complementary, and Alternative Medicines 8, no. 5 Suppl (July 3, 2011): 208–13. doi:10.4314/ajtcam.v8i5S.9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252722/

[69]Kaurav, Bhanu P. S., Manish M. Wanjari, Amol Chandekar, Nagendra Singh Chauhan, and Neeraj Upmanyu. “Influence of Withania Somnifera on Obsessive Compulsive Disorder in Mice.” Asian Pacific Journal of Tropical Medicine 5, no. 5 (May 2012): 380–84. doi:10.1016/S1995-7645(12)60063-7. https://www.ncbi.nlm.nih.gov/pubmed/22546655

[70]Sultana, N. “Hepatoprotective Role of Ashwagandha (Withania Somnifera) Root Extract against Gentamicin Induced Liver Damage in Rats.” Proceedings of The Physiological Society Proc 37th IUPS (2013). https://www.physoc.org/proceedings/abstract/Proc%2037th%20IUPSPCB197.

[71]Mwitari, Peter G., Peter A. Ayeka, Joyce Ondicho, Esther N. Matu, and Christine C. Bii. “Antimicrobial Activity and Probable Mechanisms of Action of Medicinal Plants of Kenya: Withania Somnifera, Warbugia Ugandensis, Prunus Africana and Plectrunthus Barbatus.” PLoS ONE 8, no. 6 (June 13, 2013). doi:10.1371/journal.pone.0065619. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681961/

[72]Bisht, Punum, and Vinita Rawat. “Antibacterial Activity of Withania Somnifera against Gram-Positive Isolates from Pus Samples.” Ayu 35, no. 3 (September 2014): 330–32. doi:10.4103/0974-8520.153757. https://www.ncbi.nlm.nih.gov/pubmed/25972723

[73]Alam, Nadia, Monzur Hossain, Md Abdul Mottalib, Siti Amrah Sulaiman, Siew Hua Gan, and Md Ibrahim Khalil. “Methanolic Extracts of Withania Somnifera Leaves, Fruits and Roots Possess Antioxidant Properties and Antibacterial Activities.” BMC Complementary and Alternative Medicine 12 (October 7, 2012): 175. doi:10.1186/1472-6882-12-175. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527235/

[74]Sharma, Arun, Ashutosh D. Deo, S. Tandel Riteshkumar, Thongam Ibemcha Chanu, and Arabinda Das. “Effect of Withania Somnifera (L. Dunal) Root as a Feed Additive on Immunological Parameters and Disease Resistance to Aeromonas Hydrophila in Labeo Rohita (Hamilton) Fingerlings.” Fish & Shellfish Immunology 29, no. 3 (September 2010): 508–12. doi:10.1016/j.fsi.2010.05.005. https://www.ncbi.nlm.nih.gov/pubmed/20580830

[75]Dikasso, Dawit, Eyassu Makonnen, Asfaw Debella, Dawit Abebe, Kelbessa Urga, Wallelign Makonnen, Daniel Melaku, Moges Kassa, and Mulugeta Guta. “Anti-Malarial Activity of Withania Somnifera L. Dunal Extracts in Mice.” Ethiopian Medical Journal 44, no. 3 (July 2006): 279–85. https://www.ncbi.nlm.nih.gov/pubmed/17447395

[76]Pandit, S., J. N. Cai, K. Y. Song, and J. G. Jeon. “Identification of Anti-Biofilm Components in Withania Somnifera and Their Effect on Virulence of Streptococcus Mutans Biofilms.” Journal of Applied Microbiology 119, no. 2 (August 2015): 571–81. doi:10.1111/jam.12851. https://www.ncbi.nlm.nih.gov/pubmed/25976122

[77]Grover, Abhinav, Shashank Prakash Katiyar, Jeyaraman Jeyakanthan, Vikash Kumar Dubey, and Durai Sundar. “Blocking Protein Kinase C Signaling Pathway: Mechanistic Insights into the Anti-Leishmanial Activity of Prospective Herbal Drugs from Withania Somnifera.” BMC Genomics 13 Suppl 7 (2012): S20. doi:10.1186/1471-2164-13-S7-S20. https://www.ncbi.nlm.nih.gov/pubmed/23281834

[78]Kim, Jae-Eun, Jun-Young Lee, Min-Jung Kang, Yu-Jin Jeong, Jin-A. Choi, Sang-Muk Oh, Kyung-Bok Lee, and Jong-Hwan Park. “Withaferin A Inhibits Helicobacter Pylori-Induced Production of IL-1β in Dendritic Cells by Regulating NF-κB and NLRP3 Inflammasome Activation.” Immune Network 15, no. 6 (December 2015): 269–77. doi:10.4110/in.2015.15.6.269. https://www.ncbi.nlm.nih.gov/pubmed/26770181

[79]Lee, Dae Hyung, In-Hye Lim, Eon-Gi Sung, Joo-Young Kim, In-Hwan Song, Yoon Ki Park, and Tae-Jin Lee. “Withaferin A Inhibits Matrix Metalloproteinase-9 Activity by Suppressing the Akt Signaling Pathway.” Oncology Reports 30, no. 2 (August 2013): 933–38. doi:10.3892/or.2013.2487. https://www.ncbi.nlm.nih.gov/pubmed/23708780

[80]Kataria, Hardeep, Sushil Kumar, Harshita Chaudhary, and Gurcharan Kaur. “Withania Somnifera Suppresses Tumor Growth of Intracranial Allograft of Glioma Cells.” Molecular Neurobiology 53, no. 6 (August 2016): 4143–58. doi:10.1007/s12035-015-9320-1. https://www.ncbi.nlm.nih.gov/pubmed/26208698

DISCLAIMER:-

The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-practitioner relationship, and should not be used as a substitute for professional diagnosis and treatment.

Please consult your health care provider, or contact the Two Frogs Healing Center for an appointment, before making any healthcare decisions or for guidance about a specific medical condition. The Two Frogs Healing Center expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. The Two Frogs Healing Center does not endorse specifically any test, treatment, or procedure mentioned on the site.

By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by the Two Frogs Healing Center. If you do not agree to the foregoing terms and conditions, you should not enter this site.

4 thoughts on “How These Four Herbs Help to Stop Bartonella Rage and Obsessive Compulsive Disorder (OCD)

  1. douglas shinn

    I had Lyme Bartonnela, Bapesisas and 6 other coinfections . I refused antibiotics and began studying. I read Steve Buhner’s books on treatment for Lyme etc. I followed hie “advanced protocol” for about 6 months. It took around 6 hours every day, but it killed all my parasitic infections. It can be done. Its very hard to do. But I still have severe symptoms, { Pain, fatigue etc.) No one can figure it out( especially any AMA trained docs. Apparently if you wait too long to treat parasitic infections permanent damage will occur. Many of my organs are compromised and do not function well. Very few people know how to kill parasites, even fewer know how to repair the damage done to patients with chronic symptoms. I am looking for someone more advanced than I am regarding Lyme etc. I know a lot but Repairing your body is very difficult even once you have killed off the parasites. Steven Burners protocol works. Read his books and follow his recommendations.

    Reply
    1. Greg Post author

      So glad to hear that Stephen Buhner’s herbs worked for you. We use many of his herbs in our remedies. In patients that have successfully treated their tick infections that still have pain and fatigue, they can have elevated viral infections like CMV, EBV, Herpes, or West Nile. Antiviral liposomal herbs and remedies, homeopathics, essential oils have been extremely helpful for the remaining symptoms caused by a stealthy viral infection. Other patients have had difficulty eliminating toxins and inflammation, so anti-toxin treatments like wet cupping, frequency specific microcurrent, and moxabustion have been extremely helpful.

      Reply
  2. Angela Berry-Koch

    Another reason that Bartonella may cause havoc is the fact that it was just determined that to evade heme destruction it has a heme binding protein on its outer cell. This would lower the heme in the body and might trigger porphyria in those that are susceptible by genetic mutations.? In such patients, porphyria would cause neuro-toxicity – overload pathways for detox (methylation and sulphuration) and make a subject more prone to adverse reactions to treatments. How would we deal with such cases? Certainly liver phase 2 strengthening would be prudent.

    Reply
    1. Greg Post author

      Bartonella is known to caused red blood cell destruction which can lead to anemia. There are multiple herbal remedies in lab studies that affect heme oxygenase-1 production in the body. The Chinese medicine term for this effect is called blood tonifying, or blood building. Other herbs have been shown to protect and enhance liver detoxification in other studies.

      Reply

Leave a Reply to douglas shinn Cancel reply

Your email address will not be published. Required fields are marked *