For people diagnosed with Lyme disease that have persistent Candida infections
by Greg Lee

Have you ever been frustrated by a really slow computer? A month ago, I was making a video and it took f-o-r-e-v-e-r to edit the final version. The computer was being choked by a group of programs called “Bloatware.” These programs ate up huge amounts of disk space and processing which turned my computer into a slow moving tortoise.

How is Bloatware that slows down your computer similar to recurring Candida infections in people also diagnosed with Lyme disease?

Just like Bloatware, Candida can slow you down by eating up your valuable energy and increasing inflammation
According to the US Centers for Disease Control (CDC), Candida lives on the skin and in the digestive tract without normally causing symptoms. Candida can cause local infections in the mouth, throat, esophagus and in the vagina. Candida can also cause systemic infections which affect the blood, heart, brain, eyes, bones, and other parts of the body¹. Symptoms found in persistent Candida infections can include leaky gut, irritable bowel syndrome², chronic fatigue³, arthritis⁴, clinical depression⁵, cerebral abscesses⁶, neck stiffness, seizures⁷, fever, chills, weakness, and death⁸. An immune system weakened by Lyme disease may make people more vulnerable to Candida infections.

Lyme disease patients may be more susceptible to recurring Candida infections
A Lyme disease infection may weaken the immune system and make people more susceptible to opportunistic Candida infections⁹. Also, many Lyme patients receive prolonged antibiotic therapy which can kill off healthy gut microbes and can lead to irritable bowel syndrome (IBS), leaky gut and Candida overgrowth¹⁰. Another theory for chronic Candida in Lyme patients is an inability to produce the necessary inflammatory compounds for eliminating yeast infections.

Chronic Candida infection patients may not be able to produce important anti-fungal inflammatory compounds
In a UK study on chronic Candida infection patients, Interleukin-2 (IL-2), Interleukin-12 (IL-12) production was significantly lower and Interleukin-6 (IL-6) production was much higher¹¹. The study indicates that Candida patients over produce IL-6 which can lead to decreased IL-12. Lower IL-12 is correlated with the inability to clear fungal infections. Patients with gastrointestinal Candida have higher levels of Interleukin-17 (IL-17) which promotes fungal colonization¹². Not only Candida, but also Lyme infections can lead to excess inflammation production.

Excess inflammatory compounds may also prevent clearing of Lyme as well as Candida
Increased IL-6 leading to decreased levels of IL-12 may enable Lyme and Candida infections to persist. In neurological Lyme patients, higher levels of inflammatory compounds including IL-6, IL-2, Interleukin-5 (IL-5), Interleukin-10 (IL-10), and CXCL13 were found in spinal fluid¹³. In a Borrelia infected mice study, decreased IL-12 lead to decreased arthritis and increased levels of Lyme disease in tissues¹⁴. In another study, increased IL-17 led to the development of destructive arthritis in mice infected with Borrelia¹⁵. Drug resistant strains of Candida may also lead to persistent yeast infections in Lyme patients.

Candida can persist despite multiple anti-fungal medications
In the US and Canada, multi-drug resistant strains of Candida have been found in immune compromised patients¹⁶. Candida can also produce a protective slime called a “biofilm” which may make infections up to 1000x more drug resistant¹⁷. As a result of resistant and biofilm forms of Candida, Lyme patients undergoing antibiotic therapy may experience recurring Candida infections.

Are there natural remedies that can help to reduce recurring symptoms by targeting antibiotic resistant and biofilm forms of Candida?

Fortunately, there are five essential oils that have been effective against drug resistant and biofilm forms of Candida
In a multiple studies, essential oils were effective at inhibiting drug resistant forms of Candida than anti-fungal medications. Other essential oils were highly effective at reducing Candida biofilms. Many of these essential oils have been used safely for years in our food supply¹⁸ and to help patients with Candida and Lyme disease to reduce relapsing symptoms. Microparticle “liposome” essential oils have greater penetration into organs and tissues in animal and lab studies¹⁹.

Anti-Drug Resistant Candida Essential Oil #1: Clove Bud
Clove bud essential oil demonstrated considerable anti-fungal properties against Fluconazole-resistant strains of Candida in one lab study²⁰. In another study, clove bud exhibited anti-biofilm activity against Candida species biofilms²¹. In another lab study, clove bud inhibited IL-6, interleukin-1beta (IL-1β), and IL-10²².

Clove bud essential oil eradicated all Lyme disease persister cells and dissolved biofilms in a lab study²³. In multiple animal and lab studies, clove bud oil has also been effective against biofilms produced by Staphylococcus aureus²⁴, E. Coli²⁵, and Aeromonas hydrophila²⁶. In multiple lab studies, clove oil inhibits Salmonella typhimurium, E. coli, B. cereus, Listeria innocua, Morganella morganii, Listeria monocytogenes, Enterobacteriaceae, S. aureus, and Pseudomonas species²⁷. This oil also posses potent anti-fungal properties against  Aspergillus flavus²⁸.

Clove bud oil use is cautioned in pregnancy. This oil has anti-coagulant properties and is cautioned with the use of diabetic medications, anticoagulant medications, after major surgery, peptic ulcer, hemophilia, and other bleeding disorders. It may interact with pethidine, MAOIs or SSRIs. It is also cautioned against using this oil on diseased or damaged, or hypersensitive skin, and with children under 2 years old This oil has US Food and Drug Administration (FDA) generally recognized as safe (GRAS) status²⁹. Similar to clove bud oil, tea tree has excellent anti-Candida properties.

Anti-Drug Resistant Candida Essential Oil #2: Tea Tree
In lab studies, tea tree oil inhibited drug resistant Candida strains³⁰ and was effective at inhibiting biofilm growth³¹. Tea tree oil was also effective against Staphylococcus epidermidis, Escherichia coli, Saccharomyces cerevisiae³², Pseudomonas aeruginosa and its biofilm,³³ Aspergillus niger, Aspergillus flavus³⁴, Aspergillus fumigatus, Penicillium chrysogenum³⁵, Mycoplasma pneumoniae, Mycoplasma hominis and Mycoplasma fermentans³⁶, group A streptococcus³⁷, Fusarium graminearum, Fusarium culmorum, Pyrenophora graminea³⁸, Alternaria alternata, Botrytis cinerea and Fusarium oxysporum³⁹ in lab and animal studies.

In an endotoxin lab study, tea tree essential oil was effective at lowering inflammatory compounds IL-1β, IL-6 and IL-10⁴⁰. In another lab study, tea tree oil decreased IL-2 and increased anti-inflammatory compound IL-4⁴¹. Caution: some cases have  been reported where tea tree oil caused allergic dermatitis when placed on the skin⁴². In five cases, high doses of this oil internally, 0.5-1.0 ml/kg, have produced central nervous system symptoms of loss of coordination, drowsiness, unconsciousness, diarrhea, and abdominal pain⁴³. Just like tea tree, geranium essential oil has multiple anti-Candida properties.

Anti-Drug Resistant Candida Essential Oil #3: Geranium
In multiple lab studies, geranium oil inhibited Fluconazole resistant Candida strains⁴⁴ and inhibited multiple Candida species biofilms⁴⁵. Geranium oil was also effective at significantly decreasing inflammatory compounds IL-6, IL-10, IL-2 and COX-2 levels when exposed to Candida proteins in another lab study⁴⁶. In a mouse study, this oil inhibited the degranulation of mast cells⁴⁷.

The use of geranium oil is cautioned with diabetes medications, drugs metabolized by CYP2B6, and has a low risk of skin sensitization⁴⁸. Just like geranium, savory reduced resistant forms of Candida.

Anti-Drug Resistant Candida Essential Oil #4: Savory
Due to their compositional similarity, winter and summer savory essential oils are grouped together here. In one lab study, winter savory essential oil was highly effective at inhibiting drug resistant strains of Candida glabrata⁴⁹. In another lab study, summer savory essential oil demonstrated substantial anti-fungal activity against Candida albicans and it’s biofilms⁵⁰.

Since these oils may inhibit blood clotting; use is cautioned with anticoagulant medications, major surgery, peptic ulcer, hemophilia, other bleeding disorders. Use is also cautioned with diabetic medications, use on mucous membranes due to a moderate risk of irritation and use on hypersensitive, diseased or damaged skin due to a low risk of skin irritation. Use is also cautioned in children under 2 years of age⁵¹. Similar to savory, lemon has demonstrated anti-Candida properties.

Anti-Drug Resistant Candida Essential Oil #5: Lemon
In lab studies, lemon essential oil was effective at inhibiting drug-resistant Candida species⁵². This oil was also 100% effective at reducing a mixed species Candida albicans and E. Coli biofilm⁵³. If applied to the skin, skin must not be exposed to sunlight or sunbed rays for 12 hours⁵⁴. These essential oils in combination may help to reduce relapsing symptoms caused by drug resistant and biofilm forms of Candida in patients with Lyme disease.

Essential oils may help to reduce recurring symptoms caused by antifungal resistant and biofilm forms of Candida
Similar to deleting the Bloatware off your computer to speed it up, a powerful combination of essential oils may help you to overcome energy draining and relapsing symptoms caused by drug resistant and biofilm forms of Candida. Formulating these remedies into microparticle liposomes may enhance the stability and extend the anti-fungal activity of these essential oils. Since these essential oils have cautions and contraindications on their use, work with a Lyme literate essential oil practitioner to develop a proper, safe, and effective strategy for your condition.

– Greg

P.S. Do you have experiences where treatment or remedies helped you reduce recurring symptoms from recurring Candida infections? Tell us about it.

>> Next step: Come to our live evening lecture: Getting Rid of Chronic Lyme Disease Issues in Frederick, Maryland on Wednesday August 1st at 6pm to learn more about treatments and remedies for multiple infections, natural methods for reducing neurological problems, inflammation, and pain caused by Lyme disease, Candida, co-infections, parasites, and mold. https://goodbyelyme.com/events/get_rid_lyme

¹ “Invasive Candidiasis | Candidiasis | Types of Fungal Diseases | Fungal Diseases | CDC,” April 25, 2018. https://www.cdc.gov/fungal/diseases/candidiasis/invasive/index.html.

² Kogan, Mikhail, Carlos Cuellar Castillo, and Melissa S. Barber. “Chronic Rhinosinusitis and Irritable Bowel Syndrome: A Case Report.” Integrative Medicine (Encinitas, Calif.) 15, no. 3 (June 2016): 44–54.

³ Evengård, Birgitta, Hanna Gräns, Elisabeth Wahlund, and Carl Erik Nord. “Increased Number of Candida Albicans in the Faecal Microflora of Chronic Fatigue Syndrome Patients during the Acute Phase of Illness.” Scandinavian Journal of Gastroenterology 42, no. 12 (December 2007): 1514–15. https://doi.org/10.1080/00365520701580397.

⁴ Murray, H. W., M. A. Fialk, and R. B. Roberts. “Candida Arthritis. A Manifestation of Disseminated Candidiasis.” The American Journal of Medicine 60, no. 4 (April 1976): 587–95.

⁵ Irving, G., D. Miller, A. Robinson, S. Reynolds, and A. J. Copas. “Psychological Factors Associated with Recurrent Vaginal Candidiasis: A Preliminary Study.” Sexually Transmitted Infections 74, no. 5 (October 1998): 334–38.

⁶ Yampolsky, Claudio, Marcelo Corti, and Ricardo Negroni. “Fungal Cerebral Abscess in a Diabetic Patient Successfully Treated with Surgery Followed by Prolonged Antifungal Therapy.” Revista Iberoamericana De Micología 27, no. 1 (March 31, 2010): 6–9. https://doi.org/10.1016/j.riam.2009.12.001.

⁷ Queiroz, L. S., A. Nucci, and J. L. De Faria. “[Systemic candidiasis with localization in the brain. Anatomo-clinical study of 5 cases].” Arquivos De Neuro-Psiquiatria 34, no. 1 (March 1976): 18031.

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¹⁰ Kogan, Mikhail, Carlos Cuellar Castillo, and Melissa S. Barber. “Chronic Rhinosinusitis and Irritable Bowel Syndrome: A Case Report.” Integrative Medicine (Encinitas, Calif.) 15, no. 3 (June 2016): 44–54.

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¹² Kumamoto, Carol A. “Inflammation and Gastrointestinal Candida Colonization.” Current Opinion in Microbiology 14, no. 4 (August 2011): 386–91. https://doi.org/10.1016/j.mib.2011.07.015.

¹³ Cerar, T., K. Ogrinc, S. Lotrič-Furlan, J. Kobal, S. Levičnik-Stezinar, F. Strle, and E. Ružić-Sabljić. “Diagnostic Value of Cytokines and Chemokines in Lyme Neuroborreliosis.” Clinical and Vaccine Immunology 20, no. 10 (October 1, 2013): 1578–84. https://doi.org/10.1128/CVI.00353-13.

¹⁴ Anguita, J, D H Persing, M Rincon, S W Barthold, and E Fikrig. “Effect of Anti-Interleukin 12 Treatment on Murine Lyme Borreliosis.” Journal of Clinical Investigation 97, no. 4 (February 15, 1996): 1028–34.

¹⁵ Burchill, Matthew A., Dean T. Nardelli, Douglas M. England, David J. DeCoster, John A. Christopherson, Steven M. Callister, and Ronald F. Schell. “Inhibition of Interleukin-17 Prevents the Development of Arthritis in Vaccinated Mice Challenged with Borrelia Burgdorferi.” Infection and Immunity 71, no. 6 (June 1, 2003): 3437–42. https://doi.org/10.1128/IAI.71.6.3437-3442.2003.

¹⁶ Colombo, Arnaldo L., João N. de Almeida Júnior, and Jesus Guinea. “Emerging Multidrug-Resistant Candida Species.” Current Opinion in Infectious Diseases 30, no. 6 (December 2017): 528–38. https://doi.org/10.1097/QCO.0000000000000411.

¹⁷ Potera, Carol. “ANTIBIOTIC RESISTANCE: Biofilm Dispersing Agent Rejuvenates Older Antibiotics.” Environmental Health Perspectives 118, no. 7 (July 2010): A288.

¹⁸ Hyldgaard, Morten, Tina Mygind, and Rikke Louise Meyer. “Essential Oils in Food Preservation: Mode of Action, Synergies, and Interactions with Food Matrix Components.” Frontiers in Microbiology 3 (January 25, 2012). https://doi.org/10.3389/fmicb.2012.00012.

¹⁹ Sherry, Mirna, Catherine Charcosset, Hatem Fessi, and Hélène Greige-Gerges. “Essential Oils Encapsulated in Liposomes: A Review.” Journal of Liposome Research 23, no. 4 (December 2013): 268–75. https://doi.org/10.3109/08982104.2013.819888.

²⁰ Pinto, Eugénia, Luís Vale-Silva, Carlos Cavaleiro, and Lígia Salgueiro. “Antifungal Activity of the Clove Essential Oil from Syzygium Aromaticum on Candida, Aspergillus and Dermatophyte Species.” Journal of Medical Microbiology 58, no. Pt 11 (November 2009): 1454–62. https://doi.org/10.1099/jmm.0.010538-0.

²¹ Khan, Mohd Sajjad Ahmad, and Iqbal Ahmad. “Biofilm Inhibition by Cymbopogon Citratus and Syzygium Aromaticum Essential Oils in the Strains of Candida Albicans.” Journal of Ethnopharmacology 140, no. 2 (March 27, 2012): 416–23. https://doi.org/10.1016/j.jep.2012.01.045.

²² Bachiega, Tatiana Fernanda, João Paulo Barreto de Sousa, Jairo Kenupp Bastos, and José Maurício Sforcin. “Clove and Eugenol in Noncytotoxic Concentrations Exert Immunomodulatory/Anti‐inflammatory Action on Cytokine Production by Murine Macrophages.” Journal of Pharmacy and Pharmacology 64, no. 4 (February 7, 2012): 610–16. https://doi.org/10.1111/j.2042-7158.2011.01440.x.

²³ Feng, Jie, Shuo Zhang, Wanliang Shi, Nevena Zubcevik, Judith Miklossy, and Ying Zhang. “Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia Burgdorferi.” Frontiers in Medicine 4 (2017). https://doi.org/10.3389/fmed.2017.00169.

²⁴ Budri, P. E., N. C. C. Silva, E. C. R. Bonsaglia, A. Fernandes Júnior, J. P. Araújo Júnior, J. T. Doyama, J. L. Gonçalves, M. V. Santos, D. Fitzgerald-Hughes, and V. L. M. Rall. “Effect of Essential Oils of Syzygium Aromaticum and Cinnamomum Zeylanicum and Their Major Components on Biofilm Production in Staphylococcus Aureus Strains Isolated from Milk of Cows with Mastitis.” Journal of Dairy Science 98, no. 9 (September 2015): 5899–5904. https://doi.org/10.3168/jds.2015-9442.

²⁵ Kim, Yong-Guy, Jin-Hyung Lee, Giyeon Gwon, Soon-Il Kim, Jae Gyu Park, and Jintae Lee. “Essential Oils and Eugenols Inhibit Biofilm Formation and the Virulence of Escherichia Coli O157:H7.” Scientific Reports 6 (November 3, 2016): 36377. https://doi.org/10.1038/srep36377.

²⁶ Husain, Fohad Mabood, Iqbal Ahmad, Mohammad Asif, and Qudsia Tahseen. “Influence of Clove Oil on Certain Quorum-Sensing-Regulated Functions and Biofilm of Pseudomonas Aeruginosa and Aeromonas Hydrophila.” Journal of Biosciences 38, no. 5 (December 2013): 835–44.

²⁷ Liu, Qing, Xiao Meng, Ya Li, Cai-Ning Zhao, Guo-Yi Tang, and Hua-Bin Li. “Antibacterial and Antifungal Activities of Spices.” International Journal of Molecular Sciences 18, no. 6 (June 16, 2017). https://doi.org/10.3390/ijms18061283.

²⁸ Srikaew, Benyapa, Narumol Matan, and Tanong Aewsiri. “Innovative Production of Fungal Pulp from Trametes Versicolor and Its Application in a Fungal Paper Box Containing Clove Oil.” Journal of Food Science and Technology 54, no. 10 (September 2017): 3058–64. https://doi.org/10.1007/s13197-017-2741-2.

²⁹ Tisserand, R. and Young. R. Essential Oil Safety: A Guide for Healthcare Professionals. Second Ed. London, Churchill Livingstone, pp. 909-913.

³⁰ Mertas, Anna, Aleksandra Garbusińska, Ewelina Szliszka, Andrzej Jureczko, Magdalena Kowalska, and Wojciech Król. “The Influence of Tea Tree Oil (Melaleuca Alternifolia) on Fluconazole Activity against Fluconazole-Resistant Candida Albicans Strains.” BioMed Research International 2015 (2015): 590470. https://doi.org/10.1155/2015/590470.

³¹ Ramage, Gordon, Steven Milligan, David F. Lappin, Leighann Sherry, Petrina Sweeney, Craig Williams, Jeremy Bagg, and Shauna Culshaw. “Antifungal, Cytotoxic, and Immunomodulatory Properties of Tea Tree Oil and Its Derivative Components: Potential Role in Management of Oral Candidosis in Cancer Patients.” Frontiers in Microbiology 3 (2012): 220. https://doi.org/10.3389/fmicb.2012.00220.

³² Schelz, Zsuzsanna, Joseph Molnar, and Judit Hohmann. “Antimicrobial and Antiplasmid Activities of Essential Oils.” Fitoterapia 77, no. 4 (June 2006): 279–85. doi:10.1016/j.fitote.2006.03.013. https://www.ncbi.nlm.nih.gov/pubmed/16690225

³³ Comin, Vanessa M., Leonardo Q. S. Lopes, Priscilla M. Quatrin, Márcia E. de Souza, Pauline C. Bonez, Francieli G. Pintos, Renata P. Raffin, Rodrigo de A. Vaucher, Diego S. T. Martinez, and Roberto C. V. Santos. “Influence of Melaleuca Alternifolia Oil Nanoparticles on Aspects of Pseudomonas Aeruginosa Biofilm.” Microbial Pathogenesis 93 (April 2016): 120–25. doi:10.1016/j.micpath.2016.01.019. https://www.ncbi.nlm.nih.gov/pubmed/26821356

³⁴ Shin, Seungwon. “Anti-Aspergillus Activities of Plant Essential Oils and Their Combination Effects with Ketoconazole or Amphotericin B.” Archives of Pharmacal Research 26, no. 5 (May 2003): 389–93. https://www.ncbi.nlm.nih.gov/pubmed/12785735

³⁵ Rogawansamy, Senthaamarai, Sharyn Gaskin, Michael Taylor, and Dino Pisaniello. “An Evaluation of Antifungal Agents for the Treatment of Fungal Contamination in Indoor Air Environments.” International Journal of Environmental Research and Public Health 12, no. 6 (June 2015): 6319–32. doi:10.3390/ijerph120606319. https://www.ncbi.nlm.nih.gov/pubmed/26042369

³⁶ Furneri, Pio Maria, Donatella Paolino, Antonella Saija, Andrena Marino, and Giuseppe Bisignano. “In Vitro Antimycoplasmal Activity of Melaleuca Alternifolia Essential Oil.” Journal of Antimicrobial Chemotherapy 58, no. 3 (September 1, 2006): 706–7. doi:10.1093/jac/dkl269. https://jac.oxfordjournals.org/content/58/3/706.full

³⁷ Tsao, N., C.-F. Kuo, H.-Y. Lei, S.-L. Lu, and K.-J. Huang. “Inhibition of Group A Streptococcal Infection by Melaleuca Alternifolia (tea Tree) Oil Concentrate in the Murine Model.” Journal of Applied Microbiology 108, no. 3 (March 2010): 936–44. doi:10.1111/j.1365-2672.2009.04487.x. https://www.ncbi.nlm.nih.gov/pubmed/19709334

³⁸ Terzi, V., C. Morcia, P. Faccioli, G. Valè, G. Tacconi, and M. Malnati. “In Vitro Antifungal Activity of the Tea Tree (Melaleuca Alternifolia) Essential Oil and Its Major Components against Plant Pathogens.” Letters in Applied Microbiology 44, no. 6 (June 2007): 613–18. doi:10.1111/j.1472-765X.2007.02128.x. https://www.ncbi.nlm.nih.gov/pubmed/17576222

³⁹ La Torre, A., F. Caradonia, M. Gianferro, M. G. Molinu, and V. Battaglia. “ACTIVITY OF NATURAL PRODUCTS AGAINST SOME PHYTOPATHOGENIC FUNGI.” Communications in Agricultural and Applied Biological Sciences 79, no. 3 (2014): 439–49. https://www.ncbi.nlm.nih.gov/pubmed/26080478

⁴⁰ Nogueira, M. N. M., S. G. Aquino, C. Rossa Junior, and D. M. P. Spolidorio. “Terpinen-4-Ol and Alpha-Terpineol (tea Tree Oil Components) Inhibit the Production of IL-1β, IL-6 and IL-10 on Human Macrophages.” Inflammation Research: Official Journal of the European Histamine Research Society … [et Al.] 63, no. 9 (September 2014): 769–78. doi:10.1007/s00011-014-0749-x. https://www.ncbi.nlm.nih.gov/pubmed/24947163

⁴¹ Caldefie-Chézet, F., C. Fusillier, T. Jarde, H. Laroye, M. Damez, M.-P. Vasson, and J. Guillot. “Potential Anti-Inflammatory Effects of Melaleuca Alternifolia Essential Oil on Human Peripheral Blood Leukocytes.” Phytotherapy Research: PTR 20, no. 5 (May 2006): 364–70. doi:10.1002/ptr.1862. https://www.ncbi.nlm.nih.gov/pubmed/16619364

⁴² Tisserand, Robert, and Rodney Young. Essential Oil Safety p. 1495.502-1503

⁴³ Tisserand, Robert, and Rodney Young. Essential Oil Safety: A Guide for Health Care Professionals. Elsevier Health Sciences, 2013. pp. 1502-1503

⁴⁴ Szweda, Piotr, Katarzyna Gucwa, Ewelina Kurzyk, Ewa Romanowska, Katarzyna Dzierżanowska-Fangrat, Anna Zielińska Jurek, Piotr Marek Kuś, and Sławomir Milewski. “Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida Albicans, Candida Glabrata and Candida Krusei Clinical Isolates.” Indian Journal of Microbiology 55, no. 2 (June 2015): 175–83. https://doi.org/10.1007/s12088-014-0508-2.

⁴⁵ Giongo, Janice Luehring, Rodrigo de Almeida Vaucher, Viviane Pedroso Fausto, Priscilla Maciel Quatrin, Leonardo Quintana Soares Lopes, Roberto Christ Vianna Santos, André Gündel, Patrícia Gomes, and Martin Steppe. “Anti-Candida Activity Assessment of Pelargonium Graveolens Oil Free and Nanoemulsion in Biofilm Formation in Hospital Medical Supplies.” Microbial Pathogenesis 100 (November 2016): 170–78. https://doi.org/10.1016/j.micpath.2016.08.013.

⁴⁶ Giongo, Janice Luehring, Rodrigo de Almeida Vaucher, Michele Rorato Sagrillo, Roberto Christ Vianna Santos, Marta M. M. F. Duarte, Vírginia Cielo Rech, Leonardo Quintana Soares Lopes, et al. “Anti-Inflammatory Effect of Geranium Nanoemulsion Macrophages Induced with Soluble Protein of Candida Albicans.” Microbial Pathogenesis 110 (September 2017): 694–702. https://doi.org/10.1016/j.micpath.2017.01.056.

⁴⁷ Kobayashi, Yuko, Harumi Sato, Mika Yorita, Hiroto Nakayama, Hironari Miyazato, Keiichiro Sugimoto, and Tomoko Jippo. “Inhibitory Effects of Geranium Essential Oil and Its Major Component, Citronellol, on Degranulation and Cytokine Production by Mast Cells.” Bioscience, Biotechnology, and Biochemistry 80, no. 6 (June 2016): 1172–78. https://doi.org/10.1080/09168451.2016.1148573.

⁴⁸ Tisserand, R. and Young. R. Essential Oil Safety: A Guide for Healthcare Professionals. Second Ed. London, Churchill Livingstone, p. 1032.

⁴⁹ Massa, N., S. Cantamessa, G. Novello, E. Ranzato, S. Martinotti, M. Pavan, A. Rocchetti, G. Berta, E. Gamalero, and E. Bona. “Antifungal Activity of Essential Oils against Azole-Resistant and Azole-Susceptible Vaginal Candida Glabrata Strains.” Canadian Journal of Microbiology, May 10, 2018, 1–17. https://doi.org/10.1139/cjm-2018-0082.

⁵⁰ Sharifzadeh, Aghil, Ali Reza Khosravi, and Shahin Ahmadian. “Chemical Composition and Antifungal Activity of Satureja Hortensis L. Essentiall Oil against Planktonic and Biofilm Growth of Candida Albicans Isolates from Buccal Lesions of HIV(+) Individuals.” Microbial Pathogenesis 96 (July 2016): 1–9. https://doi.org/10.1016/j.micpath.2016.04.014.

⁵¹ Tisserand, R. and Young. R. Essential Oil Safety: A Guide for Healthcare Professionals. Second Ed. London, Churchill Livingstone, pp 1444 – 1445.

⁵² Szweda, Piotr, Katarzyna Gucwa, Ewelina Kurzyk, Ewa Romanowska, Katarzyna Dzierżanowska-Fangrat, Anna Zielińska Jurek, Piotr Marek Kuś, and Sławomir Milewski. “Essential Oils, Silver Nanoparticles and Propolis as Alternative Agents Against Fluconazole Resistant Candida Albicans, Candida Glabrata and Candida Krusei Clinical Isolates.” Indian Journal of Microbiology 55, no. 2 (June 2015): 175–83. https://doi.org/10.1007/s12088-014-0508-2.

⁵³ Oliveira, Sarah Almeida Coelho, Jéssica Rabelo Mina Zambrana, Fernanda Bispo Reis Di Iorio, Cristiane Aparecida Pereira, and Antonio Olavo Cardoso Jorge. “The Antimicrobial Effects of Citrus Limonum and Citrus Aurantium Essential Oils on Multi-Species Biofilms.” Brazilian Oral Research 28 (2014): 22–27.

⁵⁴ Tisserand, R. and Young. R. Essential Oil Safety: A Guide for Healthcare Professionals. Second Ed. London, Churchill Livingstone, p 1153.

Image courtesy of Wikimedia Commons https://commons.wikimedia.org/wiki/File:The_Puffer_Fish.jpg

For people with recurring Lyme disease symptoms that still struggle despite months of several antibiotics

by Greg Lee

Have you heard of the Greek mythical monster called the Hydra? It was a huge serpent with nine poisonous heads. Heracles the Greek divine hero, aka Hercules in Roman mythology, was sent to kill this monster. Whenever Heracles cut off one head, two grew back in it’s place. Heracles was soon overwhelmed by the growing number of serpent heads. Fortunately, his nephew Iolaus used a torch to cauterize the severed stumps before more heads could grow back. No longer swarmed by double serpent heads, Heracles overcame and killed the hydra.

How is a hydra that can keep growing new heads similar to fighting Lyme disease that persists despite antibiotic treatment?

Similar to the mythical hydra, persistent Lyme disease can keep spreading despite blasting it with powerful antibiotics
In lab studies, Lyme disease bacteria can develop persistent forms called round bodies and cysts that are not killed by antibiotics. Lyme bacteria can also produce a slime called “biofilm” which can make infections up to 1000x more drug resistant^[1]. Lyme patients with persistent infections can continue to struggle with multiple recurring symptoms.

Lyme disease patients can have recurring, multiple symptoms despite antibiotic treatment
Despite receiving antibiotic therapy, patients diagnosed with Lyme disease have reported recurring symptoms of fatigue, muscular and joint pain, neurological impairment^[2], arthritis^[3], upper and lower extremity neuropathic pain^[4], and dementia^[5]. Approximately 10-20% of Lyme patients report recurring symptoms after two to four weeks of antibiotics^[6]. One theory for this relapse is that persistent forms of Lyme disease that have survived antibiotic treatment. These bacteria are not stopped by antibiotics and continue to create recurring symptoms. One area where these persistent forms can create problems is in the brain.

Brain samples from Alzheimer’s patients contain persistent forms of Lyme disease
Atypical and cystic forms of Lyme disease in were found in the cerebral cortex region of the brain of patients diagnosed with neurological Lyme^[7]. Lyme disease biofilms were also discovered in the the brain tissues of patients diagnosed with Alzheimer’s^[8]. Given the increased drug resistant nature of biofilms and persistent forms of Lyme disease, some Lyme literate medical providers have resorted to using multiple  antibiotics.

Multiple antibiotics are being used to target persistent forms of Lyme disease
In a lab study, Lyme disease persisters were killed more effectively with a combination of three antibiotics: Daptomycin, cefuroxime, and doxycycline^[9]. A Lyme literate doctor recommended the use of multiple antibiotics including one called Dapsone for minimum length of seven months or longer^[10]. Unfortunately, there can be multiple side effects from prolonged antibiotic treatment for Lyme disease.

Patients can experience multiple side effects from prolonged antibiotic treatment for Lyme
Lyme disease patients receiving oral and intravenous antibiotics have reported different side effects from skin photosensitivity reactions and gastrointestinal symptoms^[11], decreased white blood cells, fever, hepatitis, Clostridium difficile-associated diarrhea^[12], meningitis^[13], and IV port infections^[14]. Lyme patients also report increased digestion issues including leaky gut syndrome, irritable bowel syndrome, or toxic die-off aka “Herxheimer” reactions^[15] as a result of their antibiotic therapy. In a rare case, prolonged antibiotic treatment has been associated with anemia and kidney damage^[16].

Are there natural remedies that can help to reduce recurring symptoms by targeting antibiotic persistent forms of Lyme disease?

Fortunately, there are five essential oils that have been effective against persister forms of Lyme disease
In a recent study, five essential oils: oregano, clove bud, cinnamon bark, citronella, and geranium were more effective at eliminating persister forms of Lyme disease than the antibiotic daptomycin^[17]. Many of these essential oils have been used safely for years in our food supply^[18] and to help patients with Lyme disease to reduce relapsing symptoms^[19]. These oils have multiple healing and infection fighting properties in lab and animal studies. Microparticle “liposome” essential oils have demonstrated greater antimicrobial properties in lab studies^[20].

Anti-Lyme Persister Essential Oil #1: Oregano
Oregano essential oil eradicated all Lyme disease persister cells and dissolved biofilms in a lab study^[21]. The major antimicrobial components of this oil are carvacrol and thymol^[22]. In multiple studies, oregano oil has also been effective against multi-drug resistant E. Coli and it’s biofilms^[23], Salmonella species, Staphylococcus aureus, Bacillus subtilis, multi-drug resistant Pseudonomas aeruginosa, Candida species, and Aspergillus niger^[24]. This oil has the ability to disrupt the “quorum sensing” communication signals that pathogens use to make biofilms in food preservation studies^[25], and can inhibit biofilm formation in multiple pathogens^[26].

In a pig study, oregano oil increased intestinal barrier integrity, decreased endotoxins, and lower inflammatory compounds^[27]. In a mouse study, a combination of oregano and thyme essential oil reduced the levels of pro-inflammatory cytokines IL-1beta, IL-6, GM-CSF, and TNFalpha and reduce damage to the colon^[28].

This essential oil is contraindicated in pregnancy and breast feeding. This oil has anti-coagulant properties and is cautioned with the use of diabetic medications, anticoagulant medications, after major surgery, peptic ulcer, hemophilia, and other bleeding disorders. It is also cautioned against using this oil on diseased or damaged, or hypersensitive skin, and with children under 2 years old^[29]. In addition to oregano oil, clove bud oil has excellent anti-Lyme properties.

Anti-Lyme Persister Essential Oil #2: Clove Bud
Clove bud essential oil also eradicated all Lyme disease persister cells and biofilms in a lab study^[30]. Eugenol is the main antimicrobial ingredient in this oil. In multiple lab studies, clove oil inhibits Salmonella typhimurium, E. coli, B. cereus, Listeria innocua, Morganella morganii, Listeria monocytogenes, Enterobacteriaceae, S. aureus, and Pseudomonas species^[31]. This oil also posses potent antifungal properties against Candida albicans^[32] and Aspergillus flavus^[33]. In lab studies, clove bud oil attenuates E. coli biofilm production^[34].

In another lab study, this oil also inhibits the production of inflammatory compounds IL-1beta and IL-6^[35] which are often elevated in patients with Lyme disease^[36].

Clove bud oil use is cautioned in pregnancy. This oil has anti-coagulant properties and is cautioned with the use of diabetic medications, anticoagulant medications, after major surgery, peptic ulcer, hemophilia, and other bleeding disorders. It may interact with pethidine, MAOIs or SSRIs. It is also cautioned against using this oil on diseased or damaged, or hypersensitive skin, and with children under 2 years old This oil has US Food and Drug Administration (FDA) generally recognized as safe (GRAS) status^[37]. Similar to clove bud oil, cinnamon bark has excellent anti-Lyme properties.

Anti-Lyme Persister Essential Oil #3: Cinnamon Bark
In a lab study, cinnamon bark essential oil eradicated all Lyme disease persister cells and biofilms^[38]. The main active compounds in cinnamon bark oil are cinnamaldehyde and eugenol^[39]. Cinnamon bark oil also inhibits methicillin resistant Staphylococcus aureus (MRSA) and it’s biofilms, Aspergillus ochraceus, Fusarium moniliforme^[40], Brucella abortus^[41], multidrug resistant Pseudonomas aeruginosa^[42], and Candida albicans and it’s biofilms^[43].

In a human skin lab study, cinnamon bark oil reduced inflammatory compounds matrix metalloproteinase-1 (MMP-1), and plasminogen activator inhibitor-1 (PAI-1)^[44]. PAI-1 is often elevated and slows the recovery in Lyme patients by creating a condition called hypercoagulation or thick blood^[45]. When encapsulated into a microparticle liposome, cinnamon bark oil was more stable and was effective longer against MRSA and it’s biofilms^[46].

Cinnamon bark oil is contraindicated in pregnancy and breast feeding. This oil has anti-coagulant properties and is cautioned with the use of diabetic medications, anticoagulant medications, after major surgery, peptic ulcer, hemophilia, and other bleeding disorders. It has a high risk of skin sensitization, is also strongly cautioned against using this oil on diseased or damaged, or hypersensitive skin. This oil has FDA GRAS status^[47]. Similar to cinnamon, citronella has anti-Lyme properties.

Anti-Lyme Persister Essential Oil #4: Citronella
In a lab study, citronella essential oil was partially effective against Lyme disease persister cells in a 21-day experiment^[48]. The main active component in citronella oil is citronellal^[49]. In lab experiments, citronella oil demonstrates excellent antifungal properties against Aspergillus niger, Aspergillus flavus Penicillium species^[50], Candida albicans and it’s biofilms^[51]. In a diabetes wound study on mice, citronella oil inhibited Candida glabrata and Candida tropicalis and decreased expression of tumor necrosis factor alpha (TNF-α) and Interleukin 1β (IL-1β)^[52].

Caution: citronella oil may interact with drugs metabolized by CYP2B6, which include alfentanil, methadone, and propofol. This oil has FDA GRAS status^[53]. Just like citronella, geranium reduced persistent forms of Lyme disease.

Anti-Lyme Persister Essential Oil #5: Geranium Bourbon
In a lab study, geranium essential oil was partially effective against Lyme disease persister cells in a 21-day experiment^[54]. The main active ingredients in this oil are citronellol and geraniol^[55]. In a lab study, geranium bourbon oil was effective at inhibiting Staphylococcus aureus^[56], multi-drug resistant S. Aureus and MRSA^[57]. Geranium oil had an antibiotic effect against Bacillus cereus, Bacillus subtilis, Escherichia coli, and Staphylococcus aureus in another lab study^[58].

This oil was also effective at reducing inflammatory compounds Interleukin-6 (IL-6), Interleukin-1, (IL-1), Interleukin-2 (IL-2) and Cyclooxygenase-2 (COX-2) levels and increased anti-inflammatory Interleukin-10 (IL-10) caused by Candida albicans in a lab study^[59]. This oil is cautioned with the use of diabetes medications, and drugs metabolized by CYP2B6, which include alfentanil, methadone, and propofol. This oil has FDA GRAS status^[60]. These essential oils in combination may help to reduce relapsing symptoms caused by persistent forms of Lyme disease.

Essential oils may help to reduce recurring symptoms caused by antibiotic persister forms of Lyme disease
Similar to cauterizing the severed heads of the mythic Hydra monster so they don’t grow back, a powerful combination of essential oils may help you to overcome persister forms of Lyme disease that are not killed by antibiotics. Formulating these remedies into microparticle liposomes may enhance the stability and extend their antimicrobial activity of these essential oils. Since these essential oils have cautions and contraindications on their use, work with a Lyme literate essential oil practitioner to develop a proper, safe, and effective essential oil formulation for your condition.

– Greg

P.S. Do you have experiences where treatment or remedies helped you reduce recurring symptoms from persistent Lyme disease? Tell us about it.

>> Next step: Come to our live evening lecture: Getting Rid of Lyme Disease in Frederick, Maryland on Monday November 6th at 6pm to learn more about treatments and remedies for multiple infections, natural methods for reducing neurological problems, inflammation, and pain caused by Lyme disease, co-infections, parasites, and mold. https://goodbyelyme.com/events/get_rid_lyme

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Image courtesy https://sites.google.com/site/herculesandthe12laborsbyalexis/labors

FOR IMMEDIATE RELEASE

Two Frogs Healing Center to host Getting Rid of Lyme Disease Talk on Monday September 11th at 6pm at the Frederick Innovative Technology Center Inc. (FITCI)

Frederick, Maryland, September 11th, 2017 – Two Frogs Healing Center, a natural treatment clinic for getting rid of persistent Lyme disease, will be hosting the Getting Rid of Lyme Disease Evening Lecture on Monday September 11th from 6pm – 9pm at the Frederick Innovative Technology Center Inc. (FITCI)

Lyme Disease is the number one vector borne illness in the US and in the US armed forces. Lyme Disease bacteria have developed multiple methods to become resistant to antibiotic treatment. These methods are believed to be the cause of relapsing symptoms of fatigue, brain fog, inflammation, and pain in chronic Lyme disease patients despite months or years of antibiotics.

At our clinic, we have successfully treated hundreds of patients diagnosed with Lyme disease and multiple tick borne coinfections. At the “Getting Rid of Lyme Disease” lecture we’ll be sharing how innovative treatments like Frequency Specific Microcurrent and highly effective natural remedies like microparticle aka “Liposomal” herbs are more effective at stopping relapsing Lyme disease and coinfection symptoms.

“Liposomes have the unique ability to penetrate deeply into cells and biofilms to get rid hidden forms of Lyme disease and coinfections,” – Greg Lee, President Two Frogs Healing Center. He will be sharing about the huge improvements that patients have received through these treatments and remedies at the Getting Rid of Lyme Disease talk on Monday.

About the Two Frogs Healing Center

The Two Frogs Healing Center has been a provider of natural remedies and treatments for helping patients to stop their persistent infections including Lyme disease, viruses, mold, bacteria, and parasites. Using advanced electrical scanning technology, Two Frogs is able to identify the underlying pathogens that are causing relapsing symptoms. Two Frogs also produces targeted, customized, natural remedies to address multiple chronic infections.  Its treatments and remedies encompass Frequency Specific Microcurrent, cold laser, acupuncture, cupping and bloodletting, craniosacral therapy, targeted Liposomal remedies, essential oils, homeopathic remedies, antimicrobial herbs, and detoxification supplements. The Two Frogs Healing Center has served the Lyme disease community since 2006 and has a clinic in the Frederick Innovative Technology Center Inc. For more information, visit www.GoodbyeLyme.com/events/get_rid_lyme.